scholarly journals Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: The SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

2021 ◽  
Vol Volume 16 ◽  
pp. 1477-1496
Author(s):  
Chunrui Zou ◽  
Frank Li ◽  
Jiwoong Choi ◽  
Babak Haghighi ◽  
Sanghun Choi ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Clinical Characteristics ◽  
Intermediate Outcome ◽  
Former Smokers ◽  
Longitudinal Imaging

scholarly journals Longitudinal Imaging-Based Clusters in Former Smokers of the COPD Cohort Associate with Clinical Characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

2020 ◽  
Author(s):  
Chunrui Zou ◽  
Frank Li ◽  
Jiwoong Choi ◽  
Babak Haghighi ◽  
Sanghun Choi ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Rapid Expansion ◽  
Rapid Progression ◽  
Cluster Number ◽  
Quantitative Ct ◽  
Cross Sectional ◽  
Former Smokers ◽  
Longitudinal Imaging ◽  
One Year ◽  
Progression Patterns

Abstract Background: Quantitative CT (qCT) imaging-based cluster analysis identified clinically meaningful COPD former-smoker subgroups (clusters) based on cross-sectional data. We aimed to identify progression clusters for former smokers using longitudinal data.Patients and Methods: We selected 472 former smokers from SPIROMICS with a baseline visit and a one-year follow-up visit. A total of 150 qCT imaging-based variables, comprising 75 variables at baseline and their corresponding progression rates, were derived from the respective inspiration and expiration scans of the two visits. The COPD progression clusters identified were then associated with subject demography, clinical variables and biomarkers.Results: COPD severities at baseline increased with increasing cluster number. Cluster 1 patients were an obese subgroup with rapid progression of functional small airway disease percentage (fSAD%) and emphysema percentage (Emph%), and preserved FEV1%predicted but impairment of FEV1/FVC ratio over one year. Cluster 2 exhibited a decrease of fSAD% and Emph%, an increase of tissue fraction at total lung capacity, airway narrowing, and a reduced post-bronchodilator FEV1%predicted but preserved FEV1/FVC ratio over one year. Cluster 3 showed rapid expansion of Emph% and an attenuation of fSAD%. Cluster 4 demonstrated severe emphysema and fSAD and significant structural alterations at baseline with rapid progression of fSAD% over one year. Subjects with different progression patterns in the same cross-sectional cluster were identified by longitudinal clustering.Conclusions: qCT imaging-based metrics at two visits for former smokers allow for the derivation of four statistically stable clusters associated with unique progression patterns and clinical characteristics. Use of baseline variables and their progression rates enables identification of longitudinal clusters, resulting in a refinement of cross-sectional clusters.

Longitudinal imaging studies in schizophrenia: the relationship between brain morphology and outcome measures

2010 ◽  
Vol 19 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Marcella Bellani ◽  
Nicola Dusi ◽  
Paolo Brambilla
Keyword(s):  
Longitudinal Studies ◽  
Outcome Measures ◽  
Brain Morphology ◽  
Imaging Studies ◽  
Longitudinal Imaging ◽  
The Relationship ◽  
Worse Prognosis

AbstractImaging studies have tried to identify morphological outcome measures of schizophrenia in the last two decades. In particular, longitudinal studies have reported a correlation between larger ventricles, decreased prefrontal volumes and worse outcome. This would potentially allow to isolate subtypes of schizophrenia patients with a worse prognosis and more evident biological impairments, ultimately helping in designing specific rehabilitation interventions.

Modeling residential indoor concentrations of PM 2.5 , NO 2 , NO x , and secondhand smoke in the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air study

Indoor Air ◽  
2020 ◽  
Author(s):  
Marina Zusman ◽  
Amanda J. Gassett ◽  
Kipruto Kirwa ◽  
R. Graham Barr ◽  
Christopher B. Cooper ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Secondhand Smoke ◽  
Pm 2.5 ◽  
Intermediate Outcome

Rivastigmine for alzheimer's disease: Canadian interpretation of intermediate outcome measures and cost implications

2000 ◽  
Vol 22 (12) ◽  
pp. 1549-1561 ◽  
Author(s):  
Jean-François Baladi ◽  
Peter A.B. Bailey ◽  
Sandra Black ◽  
Rémi W. Bouchard ◽  
Karl D. Farcnik ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Outcome Measures ◽  
Intermediate Outcome ◽  
Cost Implications

scholarly journals TA Treatment of Emetophobia - A Hermeneutic Single-Case Efficacy Design Study – ‘Peter’

2013 ◽  
Vol 4 (2) ◽  
Author(s):  
Colin Kerr
Keyword(s):  
Outcome Measures ◽  
Strong Evidence ◽  
Clinical Characteristics ◽  
Single Case ◽  
White Male ◽  
Male Student ◽  
Case Record ◽  
Literature Reviews ◽  
The Uk

This study reports on theapplication of Hermeneutic Single Case Efficacy Design (HSCED) (Elliott 2002) to a 39 session TA-based psychotherapy intervention with a 19 year old white male student in the UK who was suffering from emetophobia. The author, who was also the researcher, provides literature reviews on emetophobia clinical characteristics,contrasts it with other phobias, and reviews prior research including TA-based approaches to phobias generally. HSCED Methodology is briefly described; quantitative outcome measures are obtained and analysed using GAD-7 (Spritzer et al 2006)and SPQ (Elliott et al 1999), and qualitative measures via a rich case record, session recordings/transcripts, and a 4-month follow-up interview.  Bohart at al’s (2011) 56 criteria for evidence adjudication were used alongside HSCED criteria. There was strong evidence of significant client changes, and that these changes were the result of the therapy.

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