scholarly journals The Relationship of Lymphocyte to High-Density Lipoprotein Ratio with Pulmonary Function in COPD

2020 ◽  
Vol Volume 15 ◽  
pp. 3159-3169
Author(s):  
Yiben Huang ◽  
Bingqian Jiang ◽  
Xiaqi Miao ◽  
Jiedong Ma ◽  
Jianing Wang ◽  
...  
2020 ◽  
Author(s):  
Congcong Ding ◽  
Yang Chen ◽  
Yumeng Shi ◽  
Minghui Li ◽  
Lihua Hu ◽  
...  

Abstract Background: Data on the relationship of nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] with the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional lipid indices with PAD in hypertensive patients.Methods: This cross-sectional study was performed among 10,900 adults with hypertension. Participants were diagnosed with PAD when their ankle-brachial index (ABI) < 0.9. The association of nontraditional lipid profiles with PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: All nontraditional lipid indices were independently and positively associated with PAD in a dose-response fashion. After multivariable adjustment, the per SD increments of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C were all significantly associated with 37%, 14%, 40%, and 24% higher risk for PAD, respectively. The adjusted ORs (95% CI) for PAD were 1.77 (1.31, 2.40), 1.71 (1.25, 2.34), 2.03 (1.50, 2.74), and 1.70 (1.25, 2.31) when comparing the highest tertile to the lowest tertile of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, respectively. Conclusions: Among Chinese hypertensive adults, all nontraditional lipid indices were positively associated with PAD, and the LDL-C/HDL-C and TC/HDL-C ratios were better for predicting PAD than other nontraditional lipid indices, which may improve the risk stratification of cardiovascular disease and dyslipidemia management. Trial registration: CHiCTR, ChiCTR1800017274. Registered 20 July 2018


1986 ◽  
Vol 39 (9) ◽  
pp. 687-697 ◽  
Author(s):  
Jane A. Cauley ◽  
Ronald E. La Porte ◽  
Rivka Black Sandler ◽  
Trevor J. Orchard ◽  
Charles W. Slemenda ◽  
...  

2020 ◽  
Author(s):  
Congcong Ding ◽  
Yang Chen ◽  
Yumeng Shi ◽  
Minghui Li ◽  
Lihua Hu ◽  
...  

Abstract Background: Data on the relationship of nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] with the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional lipid indices with PAD in hypertensive patients.Methods: This cross-sectional study was performed among 10,900 adults with hypertension. Participants were diagnosed with PAD when their ankle-brachial index (ABI) < 0.9. The association of nontraditional lipid profiles with PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: All nontraditional lipid indices were independently and positively associated with PAD in a dose-response fashion. After multivariable adjustment, the per SD increments of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C were all significantly associated with 37%, 14%, 40%, and 24% higher risk for PAD, respectively. The adjusted ORs (95% CI) for PAD were 1.77 (1.31, 2.40), 1.71 (1.25, 2.34), 2.03 (1.50, 2.74), and 1.70 (1.25, 2.31) when comparing the highest tertile to the lowest tertile of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, respectively. Conclusions: Among Chinese hypertensive adults, all nontraditional lipid indices were positively associated with PAD, and the LDL-C/HDL-C and TC/HDL-C ratios were better for predicting PAD than other nontraditional lipid indices, which may improve the risk stratification of cardiovascular disease and dyslipidemia management. Trial registration: CHiCTR, ChiCTR1800017274. Registered 20 July 2018


Metabolism ◽  
1983 ◽  
Vol 32 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Carolyn E. Moore ◽  
G.Harley Hartung ◽  
Robert E. Mitchell ◽  
Camille M. Kappus ◽  
Jody Hinderlitter

1981 ◽  
Author(s):  
J H Winter ◽  
B Bennett ◽  
F McTaggart ◽  
A S Douglas

The relationship between serum lipids and the plasma and serum anti thrombin activity was studied in blood samples from 18 patients who had suffered myocardial infarction 1-3 years previously and 18 age matched controls without clinical evidence of vascular disease. Progressive anti thrombin activity was measured by the technique of Abildgaard et al (1970) and anti thrombin III levels were measured by radial immunodiffusion using Partigen plates.Plasma specific anti thrombin activity was defined as the ratio of progressive anti thrombin activity to the anti thrombin III level measured by immunoassay. Serum was separated from blood incubated for 1 hour at 37°C in glass tubes.Serum tryglycerides were determined using a commercial kinetic enzymatic method, heparin precipitable lipoproteins (VLDL and LDL) by nephephelometric method, and high density lipoprotein by a Mn2+ and heparin precipitation method. A negative correlation was found between plasma specific anti thrombin activity and serum triglycerides (R = -0.35 p < 0.05). Significant correlations were found between the consumption of anti thrombin activity during clotting and serum triglyceride (R = -0.53, p < 0.001) heparin precipitable lipoproteins (R = -0.48, p < 0.01) and high density lipoprotein (R = + 0.40, p < 0.01).These data indicate that blood lipids influence antithrombin III - coagulant interactions, possibly protecting the activated coagulant factors from inhibition by antithrombin. The data concerning anti thrombin-lipid interactions clearly merits expansion.


2011 ◽  
Vol 31 (2) ◽  
pp. 224-226
Author(s):  
Cheng-cheng YI ◽  
WEN-wen LIU ◽  
Ying-qiu ZHANG ◽  
Zhi-jun GUO ◽  
Xiang-yun WANG ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document