The relationship of high-density lipoprotein cholesterol to new-onset diabetes: a review

2014 ◽  
Vol 4 (4) ◽  
pp. 355-365
Author(s):  
Roderick C Deaño ◽  
Henry A Tran ◽  
Peter M Okin
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Onset Diabetes ◽  
Relationship Of ◽  
The Relationship ◽  
New Onset

scholarly journals Positive association between the ratio of triglycerides to high-density lipoprotein cholesterol and diabetes incidence in Korean adults

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Joungyoun Kim ◽  
Sang-Jun Shin ◽  
Ye-Seul Kim ◽  
Hee-Taik Kang
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
National Health ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Korean Adults ◽  
Onset Diabetes ◽  
New Onset

Abstract Background Insulin resistance is associated with the incidence of diabetes and cardiovascular diseases such as myocardial infarction. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is positively correlated with insulin resistance. This study aimed to investigate the relationship between the TG/HDL-C ratio and the incidence of diabetes in Korean adults. Methods This retrospective study used data from the National Health Insurance Service-National Health Screening Cohort. The TG/HDL-C ratio was divided into three tertiles, the T1, T2, and T3 groups, based on sex. We estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) for diabetes using multivariate Cox proportional hazards regression analyses. Results A total of 80,693 subjects aged between 40 and 79 years were enrolled. The median follow-up period was 5.9 years. The estimated cumulative incidence of diabetes in the T1, T2, and T3 groups was 5.94%, 8.23%, and 13.50%, respectively, in men and 4.12%, 4.72%, and 6.85%, respectively, in women. Compared to T1, the fully adjusted HRs (95% CIs) of the T2 and T3 groups for new-onset diabetes were 1.17 (1.06–1.30) and 1.47 (1.34–1.62), respectively, in men and 1.20 (1.02–1.42) and 1.52 (1.30–1.78), respectively, in women. Conclusions Increased TG/HDL-C ratio was significantly associated with a higher risk of new-onset diabetes in both sexes.

scholarly journals Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

2020 ◽  
Author(s):  
Congcong Ding ◽  
Yang Chen ◽  
Yumeng Shi ◽  
Minghui Li ◽  
Lihua Hu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Ankle Brachial Index ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Relationship Of ◽  
The Relationship

Abstract Background: Data on the relationship of nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] with the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional lipid indices with PAD in hypertensive patients.Methods: This cross-sectional study was performed among 10,900 adults with hypertension. Participants were diagnosed with PAD when their ankle-brachial index (ABI) < 0.9. The association of nontraditional lipid profiles with PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: All nontraditional lipid indices were independently and positively associated with PAD in a dose-response fashion. After multivariable adjustment, the per SD increments of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C were all significantly associated with 37%, 14%, 40%, and 24% higher risk for PAD, respectively. The adjusted ORs (95% CI) for PAD were 1.77 (1.31, 2.40), 1.71 (1.25, 2.34), 2.03 (1.50, 2.74), and 1.70 (1.25, 2.31) when comparing the highest tertile to the lowest tertile of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, respectively. Conclusions: Among Chinese hypertensive adults, all nontraditional lipid indices were positively associated with PAD, and the LDL-C/HDL-C and TC/HDL-C ratios were better for predicting PAD than other nontraditional lipid indices, which may improve the risk stratification of cardiovascular disease and dyslipidemia management. Trial registration: CHiCTR, ChiCTR1800017274. Registered 20 July 2018

The relationship of physical activity to high density lipoprotein cholesterol in postmenopausal women

1986 ◽  
Vol 39 (9) ◽  
pp. 687-697 ◽  
Author(s):  
Jane A. Cauley ◽  
Ronald E. La Porte ◽  
Rivka Black Sandler ◽  
Trevor J. Orchard ◽  
Charles W. Slemenda ◽  
...  
Keyword(s):  
Physical Activity ◽  
High Density Lipoprotein ◽  
Postmenopausal Women ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Relationship Of ◽  
The Relationship

scholarly journals Association between nontraditional lipid profiles and peripheral arterial disease in Chinese adults with hypertension

2020 ◽  
Author(s):  
Congcong Ding ◽  
Yang Chen ◽  
Yumeng Shi ◽  
Minghui Li ◽  
Lihua Hu ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Ankle Brachial Index ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Relationship Of ◽  
The Relationship

Abstract Background: Data on the relationship of nontraditional lipid profiles [total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, non-high-density lipoprotein cholesterol (non-HDL-C)] with the risk of peripheral artery disease (PAD) are limited. The present study investigated the relationship of nontraditional lipid indices with PAD in hypertensive patients.Methods: This cross-sectional study was performed among 10,900 adults with hypertension. Participants were diagnosed with PAD when their ankle-brachial index (ABI) < 0.9. The association of nontraditional lipid profiles with PAD was examined using multivariate logistic regression analysis and the restricted cubic spline.Results: All nontraditional lipid indices were independently and positively associated with PAD in a dose-response fashion. After multivariable adjustment, the per SD increments of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C were all significantly associated with 37%, 14%, 40%, and 24% higher risk for PAD, respectively. The adjusted ORs (95% CI) for PAD were 1.77 (1.31, 2.40), 1.71 (1.25, 2.34), 2.03 (1.50, 2.74), and 1.70 (1.25, 2.31) when comparing the highest tertile to the lowest tertile of the TC/HDL-C, TG/HDL-C, LDL-C/HDL-C ratios and non-HDL-C, respectively. Conclusions: Among Chinese hypertensive adults, all nontraditional lipid indices were positively associated with PAD, and the LDL-C/HDL-C and TC/HDL-C ratios were better for predicting PAD than other nontraditional lipid indices, which may improve the risk stratification of cardiovascular disease and dyslipidemia management. Trial registration: CHiCTR, ChiCTR1800017274. Registered 20 July 2018

The relationship of exercise and diet on high-density lipoprotein cholesterol levels in women

Metabolism ◽  
1983 ◽  
Vol 32 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Carolyn E. Moore ◽  
G.Harley Hartung ◽  
Robert E. Mitchell ◽  
Camille M. Kappus ◽  
Jody Hinderlitter
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Levels ◽  
Relationship Of ◽  
The Relationship

Relationship of low- and high-density lipoprotein cholesterol with atherosclerosis

2011 ◽  
Vol 31 (2) ◽  
pp. 224-226
Author(s):  
Cheng-cheng YI ◽  
WEN-wen LIU ◽  
Ying-qiu ZHANG ◽  
Zhi-jun GUO ◽  
Xiang-yun WANG ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Relationship Of
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