scholarly journals Effects of long-term macrolide therapy at low doses in stable COPD

2019 ◽  
Vol Volume 14 ◽  
pp. 1289-1298
Author(s):  
Yueqin Cao ◽  
Shurui Xuan ◽  
Yunhui Wu ◽  
Xin Yao
Keyword(s):  
Low Doses

Long-term 238Pu and 239Pu Retention and Organ Distribution in Mice at Low Doses

1983 ◽  
Vol 44 ◽  
pp. 505-511
Author(s):  
U. Andreozzi ◽  
G. F. Clemente ◽  
G. Ingrao ◽  
G. Santori
Keyword(s):  
Organ Distribution ◽  
Low Doses

scholarly journals Long-Term Administration of Low Doses of Mycotoxins in Poultry

1987 ◽  
Vol 66 (1) ◽  
pp. 47-50 ◽  
Author(s):  
C. MICCO ◽  
M. MIRAGLIA ◽  
R. ONORI ◽  
A. IOPPOLO ◽  
A. MANTOVANI
Keyword(s):  
Low Doses ◽  
Term Administration

Sialidosis type 1: Long-term care of two unrelated patients and effectiveness of low doses of Perampanel

2021 ◽  
Vol 429 ◽  
pp. 117685
Author(s):  
Claudia Cuccurullo ◽  
Lia Santulli ◽  
Serena Troisi ◽  
Paola Russo ◽  
Anna Catone ◽  
...  
Keyword(s):  
Long Term Care ◽  
Low Doses ◽  
Term Care

scholarly journals Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

2020 ◽  
Vol 10 ◽  
Author(s):  
Caterina F. Donini ◽  
Myriam El Helou ◽  
Anne Wierinckx ◽  
Balázs Győrffy ◽  
Sophie Aires ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Low Doses ◽  
Mammary Cells

scholarly journals Immunological and genetic indices in workers under long-term exposure to low-doses of acrylonitrile

2021 ◽  
Vol 100 (10) ◽  
pp. 1115-1122
Author(s):  
Nina V. Zaitseva ◽  
Tatyana S. Ulanova ◽  
Oleg V. Dolgikh ◽  
Tatyana V. Nurislamova ◽  
Olga A. Kazakova ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Malonic Dialdehyde ◽  
Test Group ◽  
Invasive Procedure ◽  
Low Doses ◽  
Non Invasive ◽  
Exhaled Air ◽  
Activated T Lymphocytes ◽  
The Impact

Introduction. Nowadays there is very relevant research on the study of the characteristics of the impact on the health of workers of low levels of harmful factors (acrylonitrile) of production during long-term exposure. Aim of the study was to examine peculiarities of immunologic and genetic indices in workers under the long-term exposure to acrylonitrile in low doses. Materials and methods. Our research object was working area air (MPCw.ar.=0.5 mg/m3) and biological media (blood and exhaled air) of workers employed at industrial rubber manufacture. Acrylonitrile was determined via a non-invasive procedure in exhaled air with samples being concentrated on sorption tubes that were then analyzed with capillary gas chromatography. Blood samples were examined to determine contents of malonic dialdehyde, lymphocytes (absolute and relative activated T-lymphocytes CD3+CD25+, absolute and relative activated T-lymphocytes CD3+CD95+), cytokines (VEGF), oncomarkers (PSA), and adrenals hormones; to do that, we applied ELISA tests and flow cytometry. Results. Acrylonitrile was established to occur in working area air in concentrations varying within MPCw.ar. range (0.007-0.015 mg/m3) being 2-3 times higher than in air inside offices at the same enterprise. We obtained statistically significant linear dependence between concentrations of acrylonitrile in the air exhaled by workers (y) and their working experience (x) that was given with the following equation: y=0.00046+0.00027x. According to the results of the laboratory examination of the workers, violations of the antioxidant defense were established. Contents of malonic dialdehyde and steroid hormones including progesterone, estradiol, and hydrocortisone that were pathogenetically linked to each other were authentically up to 3.2 times higher in the test group than in the reference one (p<0.05). Risk for antioxidant protection disorders such as elevated malonic dialdehyde contents in blood plasma might occur in the test group was 1.58 times higher than in the reference one. Conclusion. We revealed certain peculiarities in polymorphism of PPARGC1A Gly482Ser rs8192678 gene, the variability of which contributes to the formation of pathology of the cardiovascular, endocrine systems, oncoproliferative states that increase the likelihood of these undesirable events.

Medium and long-term effects of low doses of Chlorpyrifos during the postnatal, preweaning developmental stage on sociability, dominance, gut microbiota and plasma metabolites

2020 ◽  
Vol 184 ◽  
pp. 109341 ◽  
Author(s):  
Cristian Perez-Fernandez ◽  
Miguel Morales-Navas ◽  
Luis Manuel Aguilera-Sáez ◽  
Ana Cristina Abreu ◽  
Laia Guardia-Escote ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Developmental Stage ◽  
Plasma Metabolites ◽  
Low Doses ◽  
Long Term Effects

Efficacy and safety of percutaneous administration of dihydrotestosterone in children of different genetic backgrounds with micropenis

2017 ◽  
Vol 30 (12) ◽  
Author(s):  
Dan Xu ◽  
Liangsheng Lu ◽  
Li Xi ◽  
Ruoqian Cheng ◽  
Zhou Pei ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Side Effects ◽  
Low Doses ◽  
Efficacy And Safety ◽  
Short Term ◽  
Term Study ◽  
Long Term Study ◽  
Percutaneous Administration ◽  
Open Prospective Study

AbstractBackground:Exogenous androgen supplement is an optional treatment for micropenis; however, its use in childhood is controversial due to potential side effects.Methods:Twenty-three children (mean age: 4.07±3.4 years) with micropenis of unknown causes harboring the 46,XY karyotype were recruited in an open prospective study. Androgen receptor (Results:Two patients were found withConclusions:Short term and local application of DHT at low doses in patients with micropenis could accelerate penile growth effectively without evident side effects; however, precautions still need be taken due to the paucity of long term study and the lack of ideal DHT dosage.

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