scholarly journals Fourier Transform Infrared Spectroscopy Monitoring of Dihydroartemisinin-Induced Growth Inhibition in Ovarian Cancer Cells and Normal Ovarian Surface Epithelial Cells

2020 ◽  
Vol Volume 12 ◽  
pp. 653-661
Author(s):  
Lei Li ◽  
Jinguang Wu ◽  
Shifu Weng ◽  
Limin Yang ◽  
Huizi Wang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Epithelial Cells ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
Ovarian Cancer Cells ◽  
Ovarian Surface Epithelial

scholarly journals Evidence and potential clinical significance of changes in gene network interactions in ovarian cancer

2015 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Christopher G. Hill ◽  
John F. McDonald
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Gene Network ◽  
Pearson Correlation ◽  
Regulatory Control ◽  
Ovarian Cancer Cells ◽  
New Class ◽  
Regulatory Mutations ◽  
Ovarian Surface Epithelial

The molecular basis of cancer is not merely the consequence of structural and/or regulatory mutations in genes, but additionally to disruptions in networks of regulatory interactions existing among these genes and other components of the genome. Disruptions in network relationships may manifest as the loss, gain or reversal of functionally significant interactive gene relationships in cancer cells. In this study, we first employ an unsupervised (Pearson correlation) approach to quantitatively estimate the overall change in network relationships between precursor (control) ovarian surface epithelial cells and ovarian cancer epithelial cells. We find that ovarian cancer cells display a significant overall reduction in correlated gene network interactions relative to normal precursor cells reflective of an overall loss of regulatory control.  We next focus on gene relationships that qualitatively change between normal and cancer samples. We find that biological processes significantly over represented among differentially expressed genes are substantially different from those associated with genes involved in qualitatively disrupted network interactions. Our findings provide novel insights into the processes underlying ovarian cancer and identify a potential new class of genes for targeted therapy.

Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients

2006 ◽  
Vol 1 (6) ◽  
pp. 2643-2649 ◽  
Author(s):  
Trevor G Shepherd ◽  
Brigitte L Thériault ◽  
Elizabeth J Campbell ◽  
Mark W Nachtigal
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Primary Culture ◽  
Ovarian Cancer Cells ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

scholarly journals Erratum: Corrigendum: Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients

2015 ◽  
Vol 10 (9) ◽  
pp. 1457-1457 ◽  
Author(s):  
Trevor G Shepherd ◽  
Brigitte L Thériault ◽  
Elizabeth J Campbell ◽  
Mark W Nachtigal
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Primary Culture ◽  
Ovarian Cancer Cells ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

scholarly journals Fourier Transform Infrared Spectroscopy: An Innovative Method for the Diagnosis of Ovarian Cancer

2021 ◽  
Vol Volume 13 ◽  
pp. 2389-2399
Author(s):  
Lei Li ◽  
Jinguang Wu ◽  
Limin Yang ◽  
Huizi Wang ◽  
Yizhuang Xu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
Innovative Method
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