scholarly journals LncRNA MAGI2-AS3 Affects Cell Invasion and Migration of Cervical Squamous Cell Carcinoma (CSCC) via Sponging miRNA-233/EPB41L3 Axis

2020 ◽  
Vol Volume 12 ◽  
pp. 4209-4216
Author(s):  
Anli Hou ◽  
Yali Zhang ◽  
Yujuan Fan ◽  
Yi Zheng ◽  
Xiuying Zhou ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cervical Squamous Cell Carcinoma ◽  
Invasion And Migration ◽  
And Migration

scholarly journals LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Fei Le ◽  
Yangqian Ou ◽  
Ping Luo ◽  
Xiaoming Zhong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Early Stage ◽  
Oral Ulcer ◽  
Jiangxi Province ◽  
Invasion And Migration ◽  
And Migration

Abstract Background Oral squamous cell carcinoma (OSCC) at early stages can be misdiagnosed as an oral ulcer (OU) due to similar symptoms, such as chronic and indurated ulcer. LncRNA NCK1-AS1 has been characterized as a key player in cervical cancer, while its role in OSCC is unknown. Methods All participants were selected at Jiangxi Province Tumor Hospital from December 2016 to December 2018. Expression levels of NCK1-AS1 and miR-100 in plasma from both OSCC and OU patients were measured by RT-qPCR. Diagnostic analysis was performed through ROC curve. Potential interactions between NCK1-AS1 and miR-100 were detected by cell transfection experiments. Cell invasion and migration were assessed by Transwell assays. Results The expression of NCK1-AS1 was upregulated in early-stage OSCC patients but not in OU patients. Upregulation of NCK1-AS1 distinguished OSCC patients from OU patients. The expression of miR-100 was inversely correlated with the expression of NCK1-AS1. Overexpression of NCK1-AS1 was followed by promoted OSCC cell invasion and migration. Overexpression of miR-100 did not affect the expression of NCK1-AS1 but inhibited the role of NCK1-AS1. Conclusions Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100.

scholarly journals Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma

2014 ◽  
Vol 15 (5) ◽  
pp. 612-622 ◽  
Author(s):  
Jinke Xu ◽  
Wei Lu ◽  
Senlin Zhang ◽  
Chuchao Zhu ◽  
Tingting Ren ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Neck Squamous Cell Carcinoma ◽  
Invasion And Migration ◽  
And Migration

scholarly journals High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma

2017 ◽  
Vol 13 (6) ◽  
pp. 4017-4026 ◽  
Author(s):  
Da Ma ◽  
Juan Fang ◽  
Ying Liu ◽  
Jing-Jing Song ◽  
Yan-Qiong Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cell ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
And Migration ◽  
High Level

RhoC Mediates Invasion and Migration of CaSki Cells Through the Rho-Associated Serine-Threonine Protein Kinase 1 Signaling Pathway

2014 ◽  
Vol 24 (2) ◽  
pp. 184-191 ◽  
Author(s):  
Rong Chen ◽  
Yuan Cheng ◽  
Youyi Zhang ◽  
Zijian Li ◽  
Li Geng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Cervical Squamous Cell Carcinoma ◽  
Control Group ◽  
Invasion And Migration ◽  
And Migration

ObjectiveThe small GTPase RhoC in human cancers is up-regulated and correlated with tumor metastasis. However, the role of Rho/Rho-associated serine-threonine protein kinase 1 (ROCK1) signaling pathway in human cervical cancer is still unclear. In this study, we examine the effects of RhoC and its major downstream target, ROCK1, on the invasion and migration of CaSki cells to investigate the role of RhoC/ROCK1 signaling pathway in the progression of cervical squamous cell carcinoma.MethodsRhoC and ROCK1 protein expression in CaSki cells was detected by Western blotting. Scratch and transwell assays were carried out to assess the effects of RhoC on invasion and migration of CaSki cells. Cell viability was assayed by MTT test after adding the ROCK1 inhibitor Y-27632 to CaSki cells.ResultsOverexpression of RhoC protein in CaSki cells significantly increases ROCK1 expression and promotes cell invasion and migration compared with the control group (P< 0.05). However, in the inhibition of ROCK1 with Y-27632 in CaSki cells when RhoC was overexpressed, the rate of invasiveness and migration was reduced remarkably (P< 0.05), dropping to comparable levels as the control.ConclusionsThis study suggested that the activation of RhoC/ROCK1 signaling pathways is likely involved in the progression of cervical squamous cell carcinoma.

Overexpression of c-fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma

2014 ◽  
Vol 44 (5) ◽  
pp. 353-360 ◽  
Author(s):  
Cong Dong ◽  
Dong-Xia Ye ◽  
Wen-Bin Zhang ◽  
Hong-Ya Pan ◽  
Zhi-Yuan Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Invasion And Migration ◽  
And Migration
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