Overexpression of c-fos promotes cell invasion and migration via CD44 pathway in oral squamous cell carcinoma

2014 ◽  
Vol 44 (5) ◽  
pp. 353-360 ◽  
Author(s):  
Cong Dong ◽  
Dong-Xia Ye ◽  
Wen-Bin Zhang ◽  
Hong-Ya Pan ◽  
Zhi-Yuan Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Invasion And Migration ◽  
And Migration

scholarly journals LncRNA NCK1-AS1 in plasma distinguishes oral ulcer from early-stage oral squamous cell carcinoma

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Fei Le ◽  
Yangqian Ou ◽  
Ping Luo ◽  
Xiaoming Zhong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Early Stage ◽  
Oral Ulcer ◽  
Jiangxi Province ◽  
Invasion And Migration ◽  
And Migration

Abstract Background Oral squamous cell carcinoma (OSCC) at early stages can be misdiagnosed as an oral ulcer (OU) due to similar symptoms, such as chronic and indurated ulcer. LncRNA NCK1-AS1 has been characterized as a key player in cervical cancer, while its role in OSCC is unknown. Methods All participants were selected at Jiangxi Province Tumor Hospital from December 2016 to December 2018. Expression levels of NCK1-AS1 and miR-100 in plasma from both OSCC and OU patients were measured by RT-qPCR. Diagnostic analysis was performed through ROC curve. Potential interactions between NCK1-AS1 and miR-100 were detected by cell transfection experiments. Cell invasion and migration were assessed by Transwell assays. Results The expression of NCK1-AS1 was upregulated in early-stage OSCC patients but not in OU patients. Upregulation of NCK1-AS1 distinguished OSCC patients from OU patients. The expression of miR-100 was inversely correlated with the expression of NCK1-AS1. Overexpression of NCK1-AS1 was followed by promoted OSCC cell invasion and migration. Overexpression of miR-100 did not affect the expression of NCK1-AS1 but inhibited the role of NCK1-AS1. Conclusions Therefore, NCK1-AS1 may promote the metastasis of OSCC by downregulating miR-100.

scholarly journals High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma

2017 ◽  
Vol 13 (6) ◽  
pp. 4017-4026 ◽  
Author(s):  
Da Ma ◽  
Juan Fang ◽  
Ying Liu ◽  
Jing-Jing Song ◽  
Yan-Qiong Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cell ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
And Migration ◽  
High Level

SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7

2017 ◽  
Vol 352 (2) ◽  
pp. 357-363 ◽  
Author(s):  
Toshikazu Takahara ◽  
Atsushi Kasamatsu ◽  
Masanobu Yamatoji ◽  
Manabu Iyoda ◽  
Hiroki Kasama ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Invasion And Migration ◽  
And Migration

scholarly journals Overexpression of DDR2 contributes to cell invasion and migration in head and neck squamous cell carcinoma

2014 ◽  
Vol 15 (5) ◽  
pp. 612-622 ◽  
Author(s):  
Jinke Xu ◽  
Wei Lu ◽  
Senlin Zhang ◽  
Chuchao Zhu ◽  
Tingting Ren ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cell Invasion ◽  
Neck Squamous Cell Carcinoma ◽  
Invasion And Migration ◽  
And Migration
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