scholarly journals Expression and clinical significance of autophagic protein LC3B and EMT markers in gastric cancer

2018 ◽  
Vol Volume 10 ◽  
pp. 1479-1486 ◽  
Author(s):  
Juan-Yi Wang ◽  
Tao Wu ◽  
Wu Ma ◽  
Shuo Li ◽  
Wen-Jiang Jing ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Emt Markers

scholarly journals Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stages

2016 ◽  
Vol 11 (3) ◽  
pp. 2271-2277 ◽  
Author(s):  
BINGYUAN FEI ◽  
FUJIAN JI ◽  
XUEBO CHEN ◽  
ZHUO LIU ◽  
SHUO LI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Beclin 1 ◽  
Clinical Stages ◽  
Cancer Tissues

Clinical significance of RacGAP1 expression at the invasive front of gastric cancer

2014 ◽  
Vol 18 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Susumu Saigusa ◽  
Koji Tanaka ◽  
Yasuhiko Mohri ◽  
Masaki Ohi ◽  
Tadanobu Shimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Invasive Front

scholarly journals Clinical Significance of MiR-137 Expression in Patients with Gastric Cancer After Radical Gastrectomy

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142377 ◽  
Author(s):  
Qiaoyan Gu ◽  
Jun Zhang ◽  
Haifeng Hu ◽  
Yu-e Tan ◽  
Shengmei Shi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Radical Gastrectomy

scholarly journals Galectin-1 Promotes Metastasis in Gastric Cancer Through a Sphingosine-1-Phosphate Receptor 1-Dependent Mechanism

2018 ◽  
Vol 51 (1) ◽  
pp. 11-30 ◽  
Author(s):  
Xiaolan You ◽  
Yuanjie Wang ◽  
Jian Wu ◽  
Qinghong Liu ◽  
Dehu Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Samples ◽  
Mesenchymal Transition ◽  
Sphingosine 1 Phosphate ◽  
Enhanced Expression ◽  
Emt Markers ◽  
Tgf Β1 ◽  
Dependent Mechanism

Background/Aims: Increased expression of galectin-1 (Gal-1) in gastric cancer (GC) promotes metastasis and correlates with poor prognosis. The mechanisms by which Gal-1 promotes GC metastasis remain unknown. Methods: Gal-1and Sphingosine-1-phosphate receptor 1 (S1PR1) were determined by immunohistochemistry(IHC) and quantitative real time polymerase chain reaction (qRT-PCR) in GC specimens. Stably transfected Gal-1 or S1PR1 into SGC7901 and MGC-803 cells, western blot and invasion assays in vitro and nude mice tumorigenicity in vivo were also employed. Results: Overexpression of Gal-1 enhanced expression of S1PR1 in SGC-7901 cells, and increased cell invasion, while knockdown Gal-1 in MGC-803 cells reduced S1PR1 expression and diminished invasion. Simultaneous knockdown of Gal-1 and overexpression of S1PR1 in MGC803 cells rescued invasive ability of MGC803 cells. S1PR1 was associated with expression of epithelial-to-mesenchymal transition (EMT) markers in vitro and in clinical samples. EMT induced in MGC-803 cells by TGF-β1 was accompanied by S1PR1 activation, while knockdown of S1PR1 reduced response to TGF-β1, suggest that Gal-1 promotes GC invasion by activating EMT through a S1PR1-dependent mechanism. Overexpression of S1PR1 promoted subcutaneous xenograft growth and pulmonary metastases, and enhanced expression of EMT markers. Conclusion: Galectin-1 promotes metastasis in gastric cancer through a S1PR1- dependent mechanism, our results indicate that targeting S1PR1 may be a novel strategy to treat GC metastasis.

scholarly journals Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer

2013 ◽  
Vol 30 (6) ◽  
pp. 2838-2844 ◽  
Author(s):  
TAKAAKI ARIGAMI ◽  
YOSHIKAZU UENOSONO ◽  
SUMIYA ISHIGAMI ◽  
SHIGEHIRO YANAGITA ◽  
TAKAHIKO HAGIHARA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Stanniocalcin 2

scholarly journals Clinical significance of phenotyping and karyotyping of circulating tumor cells in patients with advanced gastric cancer

Oncotarget ◽  
2014 ◽  
Vol 5 (16) ◽  
pp. 6594-6602 ◽  
Author(s):  
Yilin Li ◽  
Xiaotian Zhang ◽  
Sai Ge ◽  
Jing Gao ◽  
Jifang Gong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Advanced Gastric Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Significance
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