scholarly journals Clinical significance of stanniocalcin 2 expression as a predictor of tumor progression in gastric cancer

2013 ◽  
Vol 30 (6) ◽  
pp. 2838-2844 ◽  
Author(s):  
TAKAAKI ARIGAMI ◽  
YOSHIKAZU UENOSONO ◽  
SUMIYA ISHIGAMI ◽  
SHIGEHIRO YANAGITA ◽  
TAKAHIKO HAGIHARA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Clinical Significance ◽  
Stanniocalcin 2

Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer

2010 ◽  
Vol 17 (10) ◽  
pp. 2601-2607 ◽  
Author(s):  
Takehiko Yokobori ◽  
Koshi Mimori ◽  
Hideshi Ishii ◽  
Masaaki Iwatsuki ◽  
Fumiaki Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Prognostic Marker ◽  
Stanniocalcin 2

scholarly journals circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer

2020 ◽  
Vol Volume 12 ◽  
pp. 5945-5956
Author(s):  
Yanhong Liu ◽  
Yuanyuan Jiang ◽  
Lidong Xu ◽  
Chongxing Qu ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression

scholarly journals MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2

2009 ◽  
Vol 20 (24) ◽  
pp. 5127-5137 ◽  
Author(s):  
Kai-Wen Hsu ◽  
Rong-Hong Hsieh ◽  
Chew-Wun Wu ◽  
Chin-Wen Chi ◽  
Yan-Hwa Wu Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Epithelial Mesenchymal Transition ◽  
Suppressive Effect ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition ◽  
Cox 2

The c-Myc promoter binding protein 1 (MBP-1) is a transcriptional suppressor of c-myc expression and involved in control of tumorigenesis. Gastric cancer is one of the most frequent neoplasms and lethal malignancies worldwide. So far, the regulatory mechanism of its aggressiveness has not been clearly characterized. Here we studied roles of MBP-1 in gastric cancer progression. We found that cell proliferation was inhibited by MBP-1 overexpression in human stomach adenocarcinoma SC-M1 cells. Colony formation, migration, and invasion abilities of SC-M1 cells were suppressed by MBP-1 overexpression but promoted by MBP-1 knockdown. Furthermore, the xenografted tumor growth of SC-M1 cells was suppressed by MBP-1 overexpression. Metastasis in lungs of mice was inhibited by MBP-1 after tail vein injection with SC-M1 cells. MBP-1 also suppressed epithelial-mesenchymal transition in SC-M1 cells. Additionally, MBP-1 bound on cyclooxygenase 2 (COX-2) promoter and downregulated COX-2 expression. The MBP-1-suppressed tumor progression in SC-M1 cells were through inhibition of COX-2 expression. MBP-1 also exerted a suppressive effect on tumor progression of other gastric cancer cells such as AGS and NUGC-3 cells. Taken together, these results suggest that MBP-1–suppressed COX-2 expression plays an important role in the inhibition of growth and progression of gastric cancer.

scholarly journals Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stages

2016 ◽  
Vol 11 (3) ◽  
pp. 2271-2277 ◽  
Author(s):  
BINGYUAN FEI ◽  
FUJIAN JI ◽  
XUEBO CHEN ◽  
ZHUO LIU ◽  
SHUO LI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Beclin 1 ◽  
Clinical Stages ◽  
Cancer Tissues

Clinical significance of RacGAP1 expression at the invasive front of gastric cancer

2014 ◽  
Vol 18 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Susumu Saigusa ◽  
Koji Tanaka ◽  
Yasuhiko Mohri ◽  
Masaki Ohi ◽  
Tadanobu Shimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Invasive Front

scholarly journals CD155T/TIGIT Signaling Regulates CD8+ T-cell Metabolism and Promotes Tumor Progression in Human Gastric Cancer

2017 ◽  
Vol 77 (22) ◽  
pp. 6375-6388 ◽  
Author(s):  
Weiling He ◽  
Hui Zhang ◽  
Fei Han ◽  
Xinlin Chen ◽  
Run Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
T Cell ◽  
Tumor Progression ◽  
Cell Metabolism ◽  
Cd8 T Cell ◽  
Human Gastric Cancer
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