scholarly journals Age-Dependent Disparities in the Prevalence of Single and Clustering Cardiovascular Risk Factors: A Cross-Sectional Cohort Study in Middle-Aged and Older Adults

2020 ◽  
Vol Volume 15 ◽  
pp. 161-169 ◽  
Author(s):  
Pawel Macek ◽  
Marek Zak ◽  
Malgorzata Terek-Derszniak ◽  
Malgorzata Biskup ◽  
Przemyslaw Ciepiela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cohort Study ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Middle Aged ◽  
Cross Sectional ◽  
Age Dependent

scholarly journals Cardiovascular risk factors and memory decline in middle-aged and older adults: the English Longitudinal Study of Ageing

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Beatriz Olaya ◽  
Maria Victoria Moneta ◽  
Martin Bobak ◽  
Josep Maria Haro ◽  
Panayotes Demakakos
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Longitudinal Study ◽  
Cognitive Decline ◽  
Cardiovascular Risk Factors ◽  
Middle Aged ◽  
Memory Decline ◽  
With Memory ◽  
English Longitudinal Study

Abstract Background We investigated the association between trajectories of verbal episodic memory and burden of cardiovascular risk factors in middle-aged and older community-dwellers. Methods We analysed data from 4372 participants aged 50–64 and 3005 persons aged 65–79 years old from the English Longitudinal Study of Ageing who were repeatedly evaluated every 2 years and had six interviews of a 10-year follow-up. We measured the following baseline risk factors: diabetes, hypertension, smoking, physical inactivity and obesity to derive a cardiovascular risk factor score (CVRFs). Adjusted linear mixed effect regression models were estimated to determine the association between number of CVFRs and six repeated measurements of verbal memory scores, separately for middle-aged and older adults. Results CVRFs was not significantly associated with memory at baseline. CVFRs was significantly associated with memory decline in middle-aged (50-64y), but not in older (65-79y) participants. This association followed a dose-response pattern with increasing number of CVFRs being associated with greater cognitive decline. Comparisons between none versus some CVRFs yielded significant differences (p < 0.05). Conclusions Our findings confirm that the effect of cumulative CVRFs on subsequent cognitive deterioration is age-dependent. CVRFs are associated with cognitive decline in people aged 50–64 years, but not in those aged ≥65 years. Although modest, the memory decline associated with accumulation of cardiovascular risk factors in midlife may increase the risk of late-life dementia.

scholarly journals Relationship between anthropometric indicators and risk factors for cardiovascular disease in adults and older adults of Rio Branco, Acre

2020 ◽  
Vol 54 ◽  
pp. 24
Author(s):  
Nathalia Silva de Lima Loureiro ◽  
Thatiana Lameira Maciel Amaral ◽  
Cledir De Araújo Amaral ◽  
Gina Torres Rego Monteiro ◽  
Maurício Teixeira Leite de Vasconcellos ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Population Based ◽  
Cross Sectional Study ◽  
Obese Adults ◽  
Cross Sectional ◽  
Adult Men ◽  
Waist Hip Ratio

OBJECTIVE: To analyze the association between anthropometric variables and cardiovascular risk factors in adults and older adults of Rio Branco, Acre. METHODS: A population-based cross-sectional study with 641 adults and 957 older adults was conducted. The statistical analyses consisted of the distribution of anthropometric variables according to the cardiovascular risk factors by frequency and dispersion measures. Pearson’s correlation coefficient and prevalence ratios (PR) were estimated with their respective 95% confidence intervals (95%CI) using the SPSS® version 20.0. RESULTS: Moderate correlations were obtained in adult men for waist-hip ratio and total cholesterol (r = 0.486; p < 0.001) and for waist-hip and triglyceride ratios (r = 0.484; p < 0.001). The highest prevalence of hypertension and diabetes in adults were observed in men; in the older adults, the prevalence of hypertension was above 65% in both sexes. The prevalence of dyslipidemia was above 78% in obese adults and older adults. When analyzing the associations, a higher strength of association was found between arterial hypertension and waist-to-stature ratio (PR = 13.42; 95%CI 12.58–14.31) and body mass index greater than 30 kg/m2 (PR = 6.61; 95%CI 6.34–6.89) in adult men. In the analysis of diabetes, the waist-hip ratio presented greater robustness in the association for women (PR = 7.53; 95%CI 6.92–8.20) and men (PR = 9.79; 95%CI 9.14–10.49). CONCLUSION: Anthropometric variables are important predictors of cardiovascular risk; however, their assessments should be performed independently, according to sex and age group.

Association between circulating Galectin-3 and arterial stiffness in older adults

VASA ◽  
2021 ◽  
Author(s):  
Xiaoming Jia ◽  
Caroline Sun ◽  
Hirofumi Tanaka ◽  
Mahmoud Al Rifai ◽  
David Aguilar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cardiovascular Risk ◽  
Arterial Stiffness ◽  
Cardiovascular Risk Factors ◽  
Smoking Status ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Cross Sectional ◽  
Galectin 3

Summary: Background: Galectin-3 (gal-3) is a β-galactoside-binding lectin associated tissue fibrosis and inflammation. There is limited understanding of the relationship between gal-3 and vascular health. Our aim was to assess the association between gal-3 and arterial stiffness in older adults. Methods: We conducted a cross-sectional study of 4275 participants (mean age of 75 years) from the Atherosclerosis Risk in Communities (ARIC) Study. Central arterial stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). We evaluated the association of gal-3 with cfPWV using multivariable linear regression. Results: The median (interquartile range) gal-3 concentration was 16.5 (13.8, 19.8) ng/mL and mean cfPWV was 1163±303 cm/s. Higher gal-3 concentration was associated with greater central arterial stiffness after adjustment for age, sex, race-center, heart rate, systolic blood pressure, anti-hypertensive medication use, and current smoking status (β=36.4 cm/s change in cfPWV per log unit change in gal-3; 95% CI: 7.2, 65.5, p=0.015). The association was attenuated after adjusting for additional cardiovascular risk factors (β=17.3, 95% CI: −14.4, 49.0). Conclusions: In community-dwelling older adults, gal-3 concentration was associated with central arterial stiffness, likely sharing common pathways with traditional cardiovascular risk factors.

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