scholarly journals Glucocorticoid-Induced Skin Atrophy: The Old and the New

2020 ◽  
Vol Volume 13 ◽  
pp. 1041-1050
Author(s):  
Elena Niculet ◽  
Carmen Bobeica ◽  
Alin L Tatu
Keyword(s):  
Skin Atrophy

Kindler's Syndrome with Recurrent Neutropenia: Report of Two Cases from Saudi Arabia

2020 ◽  
Author(s):  
Yousef Binamer ◽  
Muzamil A. Chisti
Keyword(s):  
Autosomal Recessive ◽  
Common Mechanism ◽  
Sequencing Analysis ◽  
Loss Of Function ◽  
Skin Atrophy ◽  
Whole Exome ◽  
Infancy And Childhood ◽  
Genetics And Genomics ◽  
New Feature ◽  
Generation Sequencing

AbstractKindler syndrome (KS) is a rare photosensitivity disorder with autosomal recessive mode of inheritance. It is characterized by acral blistering in infancy and childhood, progressive poikiloderma, skin atrophy, abnormal photosensitivity, and gingival fragility. Besides these major features, many minor presentations have also been reported in the literature. We are reporting two cases with atypical features of the syndrome and a new feature of recurrent neutropenia. Whole exome sequencing analysis was done using next-generation sequencing which detected a homozygous loss-of-function (LOF) variant of FERMT1 in both patients. The variant is classified as a pathogenic variant as per the American College of Medical Genetics and Genomics guidelines. Homozygous LOF variants of FERMT1 are a common mechanism of KS and as such confirm the diagnosis of KS in our patients even though the presentation was atypical.

Less is more when treating the nasal ala with superficial radiotherapy

2020 ◽  
Vol 7 (3) ◽  
pp. 66-69
Author(s):  
Lucy M Butcher ◽  
Gerald B Fogarty ◽  
Susan Sinclair ◽  
Hanna Kuchel ◽  
Robert Paver
Keyword(s):  
Functional Outcomes ◽  
Skin Atrophy ◽  
Functional Importance ◽  
Less Is More ◽  
Skin Cancers ◽  
Nasal Ala ◽  
Cosmetic Outcomes ◽  
Standard Fractionation ◽  
Comparative Trials ◽  
Common Malignancy

Skin cancer is the most common malignancy, is increasing in incidence, and occurs most commonly on the head and neck. Cancers of the nasal ala pose therapeutic challenges given the cosmetic and functional importance. Both surgery and radiotherapy (RT) have similar oncological outcomes. RT is tissue-conserving and may have an advantage in cosmetic and functional outcomes, but more comparative trials are needed. RT needs to be delivered well to avoid late effects such as skin atrophy, fibrosis and telangiectasia, which may increase with higher dose per fraction. We describe three cases of self-reported thinning of the nasal ala following definitive mildly hypofractionated superficial radiotherapy (SXRT) of 2.5 Gy per fraction. SXRT to skin cancers of the nasal alar with standard fractionation of at most 2 Gy per fraction may be important in ensuring excellent cosmetic outcomes and patient satisfaction.

Surgical Answer to Intralesional Steroid–Induced Skin Atrophy

2017 ◽  
Vol 43 (4) ◽  
pp. 591-592 ◽  
Author(s):  
Karalikkattil T. Ashique ◽  
Feroze Kaliyadan
Keyword(s):  
Skin Atrophy ◽  
Intralesional Steroid

Effect of RU 38486 on skin atrophy and anti-inflammation induced by glucocorticoid

1992 ◽  
Vol 4 (2) ◽  
pp. 127
Author(s):  
E. Mishima ◽  
K. Iwasaki ◽  
M. Miura ◽  
N. Sakai ◽  
S. Shimao
Keyword(s):  
Skin Atrophy ◽  
Anti Inflammation

scholarly journals Collagen peptide and vitamin C additively attenuate age-related skin atrophy inSod1-deficient mice

2014 ◽  
Vol 78 (7) ◽  
pp. 1212-1220 ◽  
Author(s):  
Shuichi Shibuya ◽  
Yusuke Ozawa ◽  
Toshihiko Toda ◽  
Kenji Watanabe ◽  
Chisa Tometsuka ◽  
...  
Keyword(s):  
Vitamin C ◽  
Skin Atrophy ◽  
Collagen Peptide ◽  
Age Related ◽  
Deficient Mice

scholarly journals Test systems for the determination of glucocorticoid receptor ligand induced skin atrophy

2011 ◽  
Vol 3 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Stefanie Schoepe ◽  
Heike Schäcke ◽  
Khusru Asadullah
Keyword(s):  
Glucocorticoid Receptor ◽  
Skin Atrophy ◽  
Receptor Ligand ◽  
Test Systems

Action of Topical Thyroid Hormone Analogues on Glucocorticoid-Induced Skin Atrophy in Mice

Thyroid ◽  
2006 ◽  
Vol 16 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Parviz Yazdanparast ◽  
Bo Carlsson ◽  
Xing-Ying Sun ◽  
Xiao-He Zhao ◽  
Thomas Hedner ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Skin Atrophy

Evaluation of skin atrophy associated with linear atrophoderma of Moulin by ultrasound imaging

2011 ◽  
Vol 65 (1) ◽  
pp. 232-233 ◽  
Author(s):  
Osamu Norisugi ◽  
Teruhiko Makino ◽  
Hiroshi Hara ◽  
Kotaro Matsui ◽  
Megumi Furuichi ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Skin Atrophy
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