scholarly journals Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives

2018 ◽  
Vol Volume 11 ◽  
pp. 387-396 ◽  
Author(s):  
Marco Morelli Coppola ◽  
Rosa Salzillo ◽  
Francesco Segreto ◽  
Paolo Persichetti
Keyword(s):  
Triamcinolone Acetonide ◽  
Patient Selection ◽  
Intralesional Injection ◽  
Keloid Scars

scholarly journals Treatment of Chalazian: a Comparative Cross-sectional Study

2019 ◽  
Vol 1 (1) ◽  
pp. 5-9
Author(s):  
Binita Bhattarai ◽  
Koshal Shrestha ◽  
Sushila Patel ◽  
Laxmi Devi Manandhar ◽  
Rosy Karki ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Complete Resolution ◽  
Cross Sectional Study ◽  
Meibomian Gland ◽  
Intralesional Injection ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Eye Symptoms

Background: Chalazion is a common eyelid disease caused by plugged meibomian glands and chronic lipogranulomatous inflammation. It can affect individuals of all ages and may cause local eye symptoms such as irritation and inflammation and cosmetic disfigurement. There are mainly three methods of treating chalazion: Intralesional Triamcinolone Acetonide (0.1-0.3 ml of 40mg/ml), Incision and Curettage and Conservative Treatment (hot compression +lid hygiene + antibiotic ointment) to the affected eyelid. To comparing which method is the best this study has been carried out Methodology: Patients with chalazion presenting to OPD from 15 March to 15 July 2017 were included in the study. They underwent any of the three procedures according to their choice. Follow up visit was done at two weeks to determine effectiveness in terms of reduction of size or complete resolution of the chalazion. Results: Out of 112 patients enrolled in study 65(58%) were females and 47(42%) were male with a male: female ratio of (0.7:1). The mean age of involvement was 25.7years (SD 10.3). At 2 weeks follow up there was complete resolution in incision and curettage (I and C) group 77 %( 41/53) and in Triamcinolone Acetonide (TA) injection group 63 %( 20/32). Pearsons correlations showed that I and C were superior to any other forms of intervention for any size of chalazion followed by intralesional injection of TA. Conclusion: Among the three methods, Incision and Curettage remained the best choice for treatment of chalazion followed by triamcinolone acetonide injection but may need multiple injections. Keywords: Chalazion, Intralesional Triamcinolone, Incision and Curettage, Meibomian Gland

A COMPARATIVE STUDY OF INTRALESIONAL TRIAMCINOLONE ACETONIDE ALONE VERSUS COMBINATION OF 5-FLUOROURACIL AND TRIAMCINOLONE ACETONIDE IN THE TREATMENT OF KELOID

2021 ◽  
pp. 71-74
Author(s):  
Neha Gupta ◽  
Vijay Paliwal ◽  
Kanchan Kumawat ◽  
Narendra Kumar ◽  
Imran Khan ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Tertiary Care ◽  
Inhibitory Effect ◽  
Combination Group ◽  
Intralesional Injection ◽  
Care Hospital ◽  
Intralesional Corticosteroid ◽  
Pyrimidine Analogue ◽  
The Difference ◽  
Group B

Background: Keloids are benign proliferative condition of dermal broblast. Intralesional corticosteroid improves keloid but associated with signicant adverse effects like dyspigmentation, tissue atrophy and telengectasia and contraindicated in certain conditions like hypertension and diabetes. 5-Fluorouracil (5-FU), a pyrimidine analogue with an inhibitory effect on TGF-β induced broblast proliferation is useful in treatment of keloids but is associated with ulceration and pain. A low dose of Triamcinolone if added to 5-FU injection overcomes these issues. Approach: This study was conducted in a tertiary care hospital. Sixty patients; thirty in each group were included. In group A, once weekly intralesional Triamcinolone and in group B, intralesional injection of Triamcinolone mixed with 5-Flurouracil in 1: 9 dilution were injected for 8 sessions. Parameters of Vancouver scale were noted at the baseline and at the end of treatment. Results: Out of 60 patients enrolled in this study. The combination group was better in improving height (62.11% vs 78%), pliability (44.14% vs 8.81%), and vascularity (55.78% vs 61.30%) and results were statistically signicant (P valve <0.05) however it was not better in improving pigmentation (43.47% vs 20%) and volume (69.79% vs 80.76%) (P valve > 0.05). Pain and pruritus improved completely (100%) in both the groups at the end of the treatment. Excellent improvement in patient and observer assessment score was seen in 96.67% vs 3.33% in combination group and TAC group respectively. The difference was statistically signicant (P valve<0.05). Combination was better irrespective of age of the patient, duration, site, and origin of keloid. All patients treated with 5 FU develop ulceration and pain. Conclusion: Both the therapies are effective but combination is superior to TAC alone. We advocate that 5-FU should be used alone, addition of TCA does not have any added advantage in therapeutic outcome rather it increases the cost of treatment.

A linear forehead lesion caused by intralesional injection of triamcinolone acetonide and treated with hyaluronic acid filler: Case report

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Arianna Piccolo ◽  
Chiara Pensa ◽  
Arianna Zangrilli ◽  
Mauro Bavetta ◽  
Laura Diluvio ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Case Report ◽  
Triamcinolone Acetonide ◽  
Intralesional Injection

scholarly journals Intralesional injection of triamcinolone acetonide for cavernous hemangiomas

Medicine ◽  
2019 ◽  
Vol 98 (37) ◽  
pp. e16986
Author(s):  
Wen-yan Wang ◽  
Luan-hong Wang ◽  
Guang Huang ◽  
Zhen-ying Lin ◽  
Han Lin
Keyword(s):  
Triamcinolone Acetonide ◽  
Intralesional Injection ◽  
Cavernous Hemangiomas

scholarly journals COMPARISON OF THE EFFECTIVENESS OF PHOSPHORUS 32 APPLICATION AND 10 MG/CC TRIAMCINOLONE ACETONIDE INTRALESIONAL INJECTION ON KELOID

2016 ◽  
Vol 4 (1) ◽  
pp. 26-31
Author(s):  
Hani Indrayati ◽  
◽  
Jono Hadi Agusni ◽  
Asmaja Soedarwoto ◽  
Achmad Hussein Kartamihardja ◽  
...  
Keyword(s):  
Triamcinolone Acetonide ◽  
Intralesional Injection

scholarly journals Intralesional cryotherapy with triamcinolone and onabotulinumtoxinA injections for umbilical keloid: A case report

2021 ◽  
Vol 7 ◽  
pp. 205951312110490
Author(s):  
Jennifer VH Tran ◽  
Shantel DJ Lultschik ◽  
Sheetal Sapra ◽  
Kevin Dong ◽  
Klaudija Gusic ◽  
...  
Keyword(s):  
Patient Satisfaction ◽  
Side Effects ◽  
Triamcinolone Acetonide ◽  
Treatment Plan ◽  
Treatment Options ◽  
High Patient Satisfaction ◽  
High Satisfaction ◽  
Keloid Scars ◽  
History Of ◽  
Low Rate

Introduction Keloid scars are therapeutically challenging and although many treatment options exist, there are no specific guidelines, and few reports have discussed keloids in the umbilical region. Methods Here, we present a successful treatment of a 31-year-old female with a history of a recurrent keloid in the umbilical region. The keloid was treated using intralesional cryotherapy followed by intralesional onabotulinumtoxinA and triamcinolone acetonide injections. Discussion The patient expressed high satisfaction, minimal side effects, and no recurrence. Conclusion Overall, due to the low rate of side effects, high patient satisfaction, and absence of recurrence, this treatment modality should be considered as an option for umbilical keloids. Lay Summary Background to subject: Keloids are a type of scar that are difficult to treat. There are many treatment options available, but there is no single best treatment for keloids that form around the belly button region. Question being asked: Is intralesional cryotherapy with intralesional onabotulinumtoxinA and triamcinolone acetonide injections effective at treating keloids in the belly button region? How the work was conducted: We treated a 31-year-old female with a keloid around the belly button region that returned after prior treatment. The keloid was treated using combination therapy of freezing the keloid from the inside out, which is called intralesional cryotherapy. This was followed by two types of injections, called onabotulinumtoxinA and triamcinolone acetonide, directly into the keloid. What we learned: Overall, due to the low rate of side effects, high patient satisfaction and the keloid not returning, this treatment plan should be considered as an option for keloids in the belly button region. What we did not learn: This treatment may or may not be effective and safe for all patients of all skin types and demographics as this treatment was performed for only one patient.

scholarly journals Effect of dehydroepiandroesterone and triamcinolone acetonide on 3T3-L1 cell line

2017 ◽  
Author(s):  
◽  
G. Gutiérrez-Iglesias
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Triamcinolone Acetonide ◽  
Biological Effects ◽  
Fibroblast Cell ◽  
Cell Protection ◽  
Molecular Alterations ◽  
Recommended Treatment ◽  
Keloid Scars ◽  
Anti Oxidant

The skin in the human is the largest organ, his integrity represents protection against various chemical, biological and mechanical agents. The injuries in this tissue are solved by forming a scar, however, different molecular alterations may overstimulate this process, leading to the formation of aberrant scars (hypertrophic or keloid). The most recommended treatment for such injuries is the intralesional application of triamcinolone acetonide (TA) and on the other hand, dehydroepiandrosterone (DHEA) is a pro-hormone that has a wide variety of biological effects such as regulation of the synthesis of collagen fibers, cell protection, anti-tumor properties, anti-inflammatory and anti-oxidant. In this paper, the combination of AT-DHEA on proliferation and cell death in fibroblast cell line 3T3-L1 was studied. The results showed that the AT 100 and 1000 M DHEA to inhibit proliferation by 50 and 40% respectively. The combination of AT-DHEA (10000-10 M) inhibits cell proliferation and induce programmed cell death, so this combination could be used in hypertrophic or keloid scars for disposal.

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