Combined treatment of hypertrophic and keloid scars with intralesional injection of corticosteroids and laser‐assisted corticosteroid delivery

2019 ◽  
Vol 32 (6) ◽  
Author(s):  
Michael Benzaquen ◽  
Anne‐Marie Collet‐Villette ◽  
Emmanuel Delaporte
Keyword(s):  
Combined Treatment ◽  
Intralesional Injection ◽  
Keloid Scars

scholarly journals Evaluating serum level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil

2022 ◽  
Vol 8 ◽  
pp. 205951312110490
Author(s):  
Noha Ezzat Mohamad ◽  
Talal Ahmed Abd El Raheem ◽  
Rania Hosny Mahmoud ◽  
Nehal Osama Hamed
Keyword(s):  
Thymidylate Synthase ◽  
Healthy Subjects ◽  
Rna Synthesis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Intralesional Injection ◽  
Keloid Scars ◽  
Control Serum ◽  
Significant Difference ◽  
Before And After ◽  
Pyrimidine Analogue

Background Keloids are fibrous lesions formed at the site of trauma due to types I and III collagen irregular production. The presence of thymidylate synthase (TS) is a must for DNA synthesis and repairs causing cell death. 5-fluorouracil (5-FU) is a fluorinated pyrimidine analogue acting as an anti-metabolic agent that inhibits thymidylate synthase and interferes with ribo-nucleic acid (RNA) synthesis. Objectives we aimed to evaluate the level of thymidylate synthase in post burn keloid patients before and after intralesional injection of 5-fluorouracil. Methods The study included 20 keloid patients and 20 healthy subjects as a control. Serum TS was estimated using commercially available enzyme-linked immunosorbent assay (ELISA) kits before and after treatment with 5-fluorouracil. Results There was a statistically significant difference in TS levels before and after 5-FU treatment (p < 0.05). Also, results have shown that 5-FU injection has good satisfactory results in treatment of keloid causing reduction in scar volume and symptoms improvement (90% of the patients improved). On the other hand, there was no statistically significant difference in TS levels and the outcomes of the treatment. Conclusion Our findings suggest that intralesional 5-FU injection in keloid has very satisfactory results. However, thymidylate synthase enzyme has a minimal role in evaluating the treatment of keloid, so further studies are required to elaborate the relation between this enzyme and keloid scars.

scholarly journals Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives

2018 ◽  
Vol Volume 11 ◽  
pp. 387-396 ◽  
Author(s):  
Marco Morelli Coppola ◽  
Rosa Salzillo ◽  
Francesco Segreto ◽  
Paolo Persichetti
Keyword(s):  
Triamcinolone Acetonide ◽  
Patient Selection ◽  
Intralesional Injection ◽  
Keloid Scars

scholarly journals Treatment of Multiple Chalazions with Intralesional Kenalog-40 Injections in Juvenile Patient: A Case Report

2013 ◽  
Vol 1 (1) ◽  
pp. 83-86
Author(s):  
Mirjana A. Janicijevic-Petrovic ◽  
Snezana Jancic ◽  
Katarina Janicijevic ◽  
Andrijana Popovic
Keyword(s):  
Case Report ◽  
Combined Treatment ◽  
Clinical Signs ◽  
Intralesional Injection ◽  
Topical Antibiotic ◽  
Upper Eyelid ◽  
Subcutaneous Injections ◽  
Steroid Injections ◽  
Multiple Primary ◽  
Upper Lid

Aim: To case report the efficacy of subcutaneous steroid injections in the treatment of multiple chalazions and to evaluate the safety of intralesional injection in primary and recurrent chalazions in juvenile patient.Case report: A 25-year-old man noticed lesions which appeared on upper lid during past three months. It was clinically presented with three focal, large and painful nodules in upper right eyelid. Inflammation process began on May the 1st of 2013. After one month in May 30th 2013 was directly administered synthetic steroid, Kenalog-40. Application of triamcinolone acetonide resulted in two satellite lesions, compared to the original, when the same incisions drained during the first surgery in July 5th 2013, with topical antibiotic-steroidal drugs and hot compresses. Second surgery was in July 26th 2013. Third surgery was performed in August 5st 2013 with second application of Kenalog-40. Combined treatment leads to recovery of clinical signs and inflammation of right upper eyelid with regressions of primary and recurrent chalazions.Conclusion: Two steroid subcutaneous injections produced complete resolution of multiple primary and recurrent chalazions. Clinical imperative was that recurrent or unusual refractory chalazions require referral to Hystopathological examination of curetting to exclude malignancy.

scholarly journals Comparison study of combination of cryotherapy & intralesional injection and multipuncture of bleomycin vs cryotherapy in resistant palmoplanter warts

2021 ◽  
Vol 42 (6) ◽  
pp. 677-683
Author(s):  
Mehdi Amirnia ◽  
Mohamad Ranjkesh ◽  
Mir ahad Mousavi
Keyword(s):  
Treatment Outcomes ◽  
Combined Treatment ◽  
Intralesional Injection ◽  
Comparison Study ◽  
The Third ◽  
Group A ◽  
Common Problems ◽  
Group B

Background: Although many warts are treated with usual methods, resistant cases are common problems. Bleomycin is one of the drugs used for resistant cases. The aim of this study was to compare the effect of cryotherapy and intralesional bleomycin injection combination with cryotherapy in the treatment of resistant warts. Methods: Sixty patients with resistant warts were selected and randomly divided into two groups of 30 A and B patients. In each group, cryotherapy was performed three sessions during 0, third and, sixth weeks in case of visible lesions. In group B, in addition to cryotherapy in week 0, and in the presence of visible lesions during week 3, injections of intra-lesions of bleomycin 1 mg/ml were administered. Treatment outcomes and possible complications were evaluated during the third and sixth weeks. Results: The response to the treatment was defined as poor, moderate, and well by the physician, which was 16.7%, 53.3% and, 10% in group A after 3 weeks of treatment, respectively and was 16.7%, 50% and, 33.3% in group B, respectively. The response to the treatment after 6 weeks of treatment was 33.3%, 40%, and 26.7% in group A and was 6.7%, 40%, and 53.3% in group B, respectively. Conclusion: Combined treatment of cryotherapy and intralesional bleomycin injection is more effective than cryotherapy in the treatment of resistant warts.

Hybrid treatment of multilevel revascularization in patients with peripheral arterial disease – a multi-centre study in Korea

VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 235-241 ◽  
Author(s):  
Soon Cheon Lee ◽  
Jin Hyun Joh ◽  
Jeong-Hwan Chang ◽  
Hyung-Kee Kim ◽  
Jang Yong Kim ◽  
...  
Keyword(s):  
Endovascular Treatment ◽  
Combined Treatment ◽  
Ankle Brachial Index ◽  
Primary Patency ◽  
Limb Ischaemia ◽  
University Hospitals ◽  
Multi Centre Study ◽  
Free Survival ◽  
Technical Success Rate ◽  
Hybrid Treatment

Abstract. Background: Endovascular treatment is an alternative first-line management for peripheral artery disease (PAD). Hybrid treatment (HT) is defined as a combined treatment for patients with PAD using endovascular and open surgery, simultaneously performed in an operating room. The results of HT are reportedly good for multilevel revascularization (MR) in patients with chronic limb ischaemia, and even in older high-risk patients. The goal of this study was to examine the clinical and haemodynamic outcomes of HT in patients who need MR. Patients and methods: Nine university hospitals in Korea participated in this multicentre study. A total of 134 patients with multilevel PAD underwent HT and MR. Patients were enrolled from July 2014 to June 2015 and were followed for 18 months. Results: The mean age of the patients was 68.8 ± 9.93 years and 88.1 % were men. Patients with Rutherford category 2 to 3 and 4 to 6 comprised 59.0 % and 42.0 % of the group, respectively. The technical success rate was 100 %. The primary patency rates at 12 and 18 months were 77.6 % and 63.9 %, respectively. The primary-assisted patency rates at 12 and 18 months were both 90.0 %. The pre-operative mean ankle brachial index (0.43 ± 0.23) increased to 0.87 ± 0.23 at six months post-operatively (t-test, p < 0.05). The amputation free survival rate was 97.1 %. Conclusions: Although outcomes of multilevel PAD are reportedly poor when endovascular treatment alone is used, we have shown that HT is a feasible alternative modality for patients with multilevel PAD, with satisfactory amputation-free survival and freedom from re-intervention rates.

A Case of Catatonia in a 14-Year-Old Girl with Schizophrenia Treated with Electroconvulsive Therapy

2013 ◽  
Vol 41 (1) ◽  
pp. 69-74 ◽  
Author(s):  
Frank Häßler ◽  
Olaf Reis ◽  
Steffen Weirich ◽  
Jacqueline Höppner ◽  
Birgit Pohl ◽  
...  
Keyword(s):  
Case Report ◽  
Treatment Response ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Combined Treatment ◽  
Adolescent Patient

This article presents a case of a 14-year-old female twin with schizophrenia who developed severe catatonia following treatment with olanzapine. Under a combined treatment with amantadine, electroconvulsive therapy (ECT), and (currently) ziprasidone alone she improved markedly. Severity and course of catatonia including treatment response were evaluated with the Bush-Francis Catatonia Rating Scale (BFCRS). This case report emphasizes the benefit of ECT in the treatment of catatonic symptoms in an adolescent patient with schizophrenic illness.

Initial evaluation of the effectiveness of individual and group plus individual (combined) treatment

2013 ◽  
Author(s):  
Halley J. Brown ◽  
Lois A. Huebner ◽  
Zac E. Imel ◽  
Alexandra R. Kelly ◽  
Elizabeth Duszak ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Initial Evaluation
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