scholarly journals The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells

2019 ◽  
Vol Volume 11 ◽  
pp. 99-110
Author(s):  
Michael Crone ◽  
Kelly Hallman ◽  
Victoria Lloyd ◽  
Monica Szmyd ◽  
Briana Badamo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Steroid Receptors ◽  
Black Cohosh ◽  
Antiestrogenic Effects

Abstract 4397: Gli Activation by Steroid Receptors in Prostate and Breast Cancer Cells

2019 ◽  
Author(s):  
Shabnam Massah ◽  
Na Li ◽  
Sarah Truong ◽  
Jane Foo ◽  
Gail Prins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Steroid Receptors

Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro studyThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.

2007 ◽  
Vol 85 (11) ◽  
pp. 1153-1159 ◽  
Author(s):  
Mahéra Al-Akoum ◽  
Sylvie Dodin ◽  
Ali Akoum
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Cell Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Black Cohosh ◽  
Proliferative Effect ◽  
Dose Dependent ◽  
Mcf 7

Breast cancer cell cultures were exposed to different concentrations of black cohosh, estradiol (E2), and tamoxifen to examine the effect on cell proliferation; cytotoxicity was assessed by using sulforhodamine B (SRB) dye solution. E2 (10−10–10−8 mol/L) markedly stimulated the proliferation of MCF-7 cells (p < 0.01). Tamoxifen stimulated MCF-7 cell proliferation at 10−6 mol/L and 10−5 mol/L (p < 0.005) but inhibited in a dose-dependent fashion the proliferative effect of E2 (p < 0.001). Black cohosh alone did not show any stimulatory effect, but exhibited a cytotoxic effect, which was significant at 103 μg/mL (p < 0.001). Adding black cohosh at 100–103 μg/mL to E2 at 10−9 mol/L also resulted in a dose-dependent inhibition of E2 proliferative effect. Interestingly, the combination of black cohosh (100–103 μg/mL) with increasing tamoxifen concentrations further inhibited MCF-7 cell growth. On MDA-MB-231 cells, neither E2 nor tamoxifen displayed any detectable effect. However, black cohosh inhibited MDA-MB-231 cell proliferation at 103 μg/mL (p < 0.05), and this inhibitory effect was enhanced by increasing tamoxifen concentrations. This study reveals a cytotoxic effect of black cohosh on both estrogen-sensitive and estrogen-insensitive breast cancer cells and a synergism with tamoxifen for inhibition of cancerous cell growth.

scholarly journals The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells

2018 ◽  
Vol Volume 10 ◽  
pp. 1-11 ◽  
Author(s):  
Monica Szmyd ◽  
Victoria Lloyd ◽  
Kelly Hallman ◽  
Katie Aleck ◽  
Viktoria Mladenovik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Black Cohosh ◽  
Er Alpha

scholarly journals Actein and a Fraction of Black Cohosh Potentiate Antiproliferative Effects of Chemotherapy Agents on Human Breast Cancer Cells

Planta Medica ◽  
2007 ◽  
Vol 73 (2) ◽  
pp. 189-189
Author(s):  
Linda Einbond ◽  
Masahito Shimizu ◽  
Paiboon Nuntanakorn ◽  
Colette Seter ◽  
Rong Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Black Cohosh ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Antiproliferative Effects ◽  
Chemotherapy Agents

Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors

2021 ◽  
Vol 210 ◽  
pp. 105876
Author(s):  
Cristina Amaral ◽  
Fabien Marc Trouille ◽  
Cristina Ferreira Almeida ◽  
Georgina Correia-da-Silva ◽  
Natércia Teixeira
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mechanism Of Action ◽  
Breast Cancer Cells ◽  
Steroid Receptors ◽  
Anti Cancer

Abstract 4397: Gli Activation by Steroid Receptors in Prostate and Breast Cancer Cells

2019 ◽  
Author(s):  
Shabnam Massah ◽  
Na Li ◽  
Sarah Truong ◽  
Jane Foo ◽  
Gail Prins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Steroid Receptors
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