scholarly journals The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells

2018 ◽  
Vol Volume 10 ◽  
pp. 1-11 ◽  
Author(s):  
Monica Szmyd ◽  
Victoria Lloyd ◽  
Kelly Hallman ◽  
Katie Aleck ◽  
Viktoria Mladenovik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Black Cohosh ◽  
Er Alpha

scholarly journals Correlates of Breast Cancer and Indole-3-Carbinol: Medicinal Development and Strategies of Natural Products

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Estrogen Receptor ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cyclin E ◽  
Luciferase Gene ◽  
Growth And Survival ◽  
Er Alpha

Estrogen-responsive breast cancer cells, such as MCF7 and T47D cells, express both estrogen receptor ER and ERß. Indole-3-carbinol (I3C) strongly down-regulated ER protein and transcript levels, without altering the level of ERß protein, in both cell lines. In cells transfected with the ER promoter linked to a luciferase gene reporter, I3C ablated ER promoter activity1-5. Dietary indole-3-carbinol prevents the development of estrogen-enhanced cancers including breast. Whereas estrogen increases the growth and survival of tumors, indole-3-carbinol causes growth arrest and increased apoptosis and ameliorates the effects of estrogen. In these findings best use indole-3-carbinol together with other nutrients (genistein) to achieve maximum benefits for cancer prevention. Investigator evaluated whether genistein, which is the major isoflavonoid in soy, would alter the ability of indole-3-carbinol/DIM to cause apoptosis and decrease expression driven by the estrogen receptor (ER)-alpha. Synergistic effect of indole-3-carbinol and genistein for induction of GADD expression, thus increasing apoptosis, and for decrease of expression driven by ER-alpha. Because of the synergistic effect of indole-3-carbinol and genistein, the potential exists for prophylactic or therapeutic efficacy of lower concentrations of each phytochemical when used in combination. I3C inhibits the enzyme elastase. High levels of elastase in breast cancer cells are suggestive of a poor prognosis because elastase shortens cyclin E, a cellular chemical involved in controlling the cell cycle, and the shortened version of cyclin E speeds up the cell cycle, therefore making cancer cells proliferate faster.I3C prevents the elastase shortening of cyclin E, thus halting the growth of breast cancer cells.

scholarly journals The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells

2017 ◽  
Vol Volume 9 ◽  
pp. 153-161 ◽  
Author(s):  
Kelly Hallman ◽  
Katie Aleck ◽  
Brigitte Dwyer ◽  
Victoria Lloyd ◽  
Meghan Quigley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
Er Alpha
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