scholarly journals The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells

2017 ◽  
Vol Volume 9 ◽  
pp. 153-161 ◽  
Author(s):  
Kelly Hallman ◽  
Katie Aleck ◽  
Brigitte Dwyer ◽  
Victoria Lloyd ◽  
Meghan Quigley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
Er Alpha

scholarly journals The regulation of tumor suppressor protein, p53, and estrogen receptor (ERα) by resveratrol in breast cancer cells

2017 ◽  
Vol 7 (11-12) ◽  
pp. 414-425 ◽  
Author(s):  
Julieta Saluzzo ◽  
Kelly M. Hallman ◽  
Katie Aleck ◽  
Brigitte Dwyer ◽  
Meghan Quigley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53

scholarly journals Apoptotic effect of Physalis minima Linn ethanol extract on breast cancer cells via p53 wild-type and Apaf-1 protein

2020 ◽  
Vol 19 (10) ◽  
pp. 2085-2089
Author(s):  
Handayani Handayani ◽  
Retno Handajani ◽  
Imam Susilo ◽  
Achmad Basori ◽  
Hotimah Masdan Salim
Keyword(s):  
Breast Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cell Line ◽  
Breast Cancer Cells ◽  
Ethanol Extract ◽  
Tumor Suppressor Protein ◽  
Tumor Suppressor Protein P53 ◽  
Protein P53 ◽  
Mcf 7

Purpose: To produce an anti-cancer agent from Physalis minima ethanol extract as well as prevent the growth of NMU-induced breast cancer and MCF-7 cell line.Methods: This research used an animal model (Wistar-Furth rats), and cell line used in this study was normal breast-cell line MCF-7. The rats were administered with the ethanol extract of Physalis minima Linn (100, 250 and 400 mg/kg/day) by gavage, once a day for 4 weeks. Meanwhile, MCF-7 cell lines were cultured in medium and incubated in 100 μg/mL of ethanol extract of Physalis minima for 48 h. The samples were analyzed using histology and immunohistochemistry techniques for expression of p53 antibody DO-1 and APAF-1.Results: The results of immunohistological analysis in the breast organ showed that Physalis minima Linn extract significantly (p < 0.05) increased the tumor suppressor protein p53 at doses of 100, 250 and 400 mg/kg/day. In addition, the extract also significantly (p < 0.05) increased APAF-1, which is a gene determining cell death, at doses of 100, 200 and 400 mg/day.Conclusion: Ethanol extract of Physalis minima Linn inhibits the cytotoxic activity of NMU-induced breast cancer by increasing the tumor suppressor protein p53 and APAF-1. Thus, Physalis minima Linn extract can potentially be used as a complementary treatment for inhibiting the growth of breast cancer cells in patients. Keywords: Apoptosis protease-activating factor-1, Breast cancer, MCF-7 cell line, Physalis minima, p53

GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells

2016 ◽  
Vol 158 (2) ◽  
pp. 263-276 ◽  
Author(s):  
Zi-Jian Lan ◽  
YunHui Hu ◽  
Sheng Zhang ◽  
Xian Li ◽  
Huaxin Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Α ◽  
Α Activity

scholarly journals The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells

2018 ◽  
Vol Volume 10 ◽  
pp. 1-11 ◽  
Author(s):  
Monica Szmyd ◽  
Victoria Lloyd ◽  
Kelly Hallman ◽  
Katie Aleck ◽  
Viktoria Mladenovik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Progesterone Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Black Cohosh ◽  
Er Alpha
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