scholarly journals Simplified Method for the Telomeric Repeat Amplification Protocol (TRAP)

BioTechniques ◽  
1998 ◽  
Vol 24 (5) ◽  
pp. 726-728 ◽  
Author(s):  
Loryn N. Sellner ◽  
Peta M. Lock ◽  
Gavin R. Turbett
Keyword(s):  
Telomeric Repeat ◽  
Telomeric Repeat Amplification Protocol ◽  
Amplification Protocol ◽  
Simplified Method

Nonradioisotopic Telomeric Repeat Amplification Protocol (TRAP) Using Digoxigenin Labeled Probe

1997 ◽  
Vol 19 (4) ◽  
pp. 451-457 ◽  
Author(s):  
Y. Wada ◽  
A. Yagihashi ◽  
H. Kameshima ◽  
A. Matsuura ◽  
N. Sato ◽  
...  
Keyword(s):  
Telomeric Repeat ◽  
Telomeric Repeat Amplification Protocol ◽  
Amplification Protocol ◽  
Labeled Probe

scholarly journals Nonradioactive, Agarose Minigel Procedure for Telomeric Repeat Amplification Protocol

BioTechniques ◽  
1997 ◽  
Vol 23 (6) ◽  
pp. 1029-1032 ◽  
Author(s):  
Dunne Fong ◽  
James P. Burke ◽  
Marion Man-Ying Chan
Keyword(s):  
Telomeric Repeat ◽  
Telomeric Repeat Amplification Protocol ◽  
Amplification Protocol

scholarly journals Telomerase Inhibition Studies of Novel Spiroketal-Containing Rubromycin Derivatives

2013 ◽  
Vol 66 (5) ◽  
pp. 530 ◽  
Author(s):  
Tsz-Ying Yuen ◽  
Yu-Pong Ng ◽  
Fanny C. F. Ip ◽  
Jack L.-Y. Chen ◽  
Darcy J. Atkinson ◽  
...  
Keyword(s):  
Real Time ◽  
Title Compound ◽  
Parent Compound ◽  
Telomerase Activity ◽  
Telomeric Repeat ◽  
Telomeric Repeat Amplification Protocol ◽  
Telomerase Inhibition ◽  
Amplification Protocol ◽  
Human Telomerase ◽  
Inhibition Studies

Twenty nine novel spiroketal derivatives related to the rubromycins were evaluated for their anti-telomerase activity using the real-time quantitative telomeric repeat amplification protocol assay. The parent compound γ-rubromycin exhibited the highest potency against human telomerase activity within the series. Modification of the spiroketal motif by the introduction of heteroatoms and substituents at different positions produced analogues with varying bioactivity. Variation at the isocoumarin subunit of the title compound resulted in weaker activity, indicative of its importance in telomerase inhibition.

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