scholarly journals Formation of cardiac fibers in Matrigel matrix

BioTechniques ◽  
2008 ◽  
Vol 44 (3) ◽  
pp. 341-348 ◽  
Author(s):  
Karina Bakunts ◽  
Nikki Gillum ◽  
Zaruhi Karabekian ◽  
Narine Sarvazyan
Keyword(s):  
Matrigel Matrix ◽  
Cardiac Fibers

scholarly journals Histopathological study of different organs of charles foster strain rat under the exposure of Pueraria tuberosa

2019 ◽  
Author(s):  
Harsh Pandey ◽  
Shivani Srivastava ◽  
Surabhi Singh ◽  
Yamini BhusanTripathi
Keyword(s):  
Adrenal Gland ◽  
Water Extract ◽  
Morphological Alteration ◽  
Histopathological Study ◽  
Morphological Alterations ◽  
Pueraria Tuberosa ◽  
Heart Size ◽  
Selection Of ◽  
Cardiac Fibers

AbstractObjectiveThe present study was undertaken to investigate the safe doses of Pueraria tuberosa water extract (PTWE) on different organs.MethodologyHaematoxylin and eosin staining was used to study the morphological alterations in heart, intestine, testis, adrenal gland and spleen. Followed the OECD guidelines 407 of repeated toxicity with respect to the selection of dose and days for different organs. The selected doses of PTWE were 250, 500, 1000 and 2000 mg/kg bw and the durations selected were 7, 14, 21 and 28 days.ResultAccording to the obtained results, we have found no any types of adverse alteration in cardiac fibers of the heart, size and shapes in crypts and villi of intestine, semeniferous tubules and spermatozoa count were normal in testis, all three zones of adrenal gland were normally identified and no any adverse sign of pulps in spleen was seen in all treated groups of PTWEConclusionThere was no any types of adverse morphological alteration found in any organs. The drug PTWE are safe at 1000 mg/kg bw upto 28 days and 2000 mg/ kg bw upto 21 days respectively.

scholarly journals Ventricular tachyrdia in the infarcted, Langendorff-perfused human heart: Role of the arrangement of surviving cardiac fibers

1990 ◽  
Vol 15 (7) ◽  
pp. 1594-1607 ◽  
Author(s):  
Jacques M.T. de Baker ◽  
Ruben Coronel ◽  
Sara Tasseron ◽  
Arthur A.M. Wilde ◽  
Tobias Opthof ◽  
...  
Keyword(s):  
Human Heart ◽  
Cardiac Fibers

Statistical Atlas of Human Cardiac Fibers: Comparison with Abnormal Hearts

2012 ◽  
pp. 207-213 ◽  
Author(s):  
Hervé Lombaert ◽  
Jean-Marc Peyrat ◽  
Laurent Fanton ◽  
Farida Cheriet ◽  
Hervé Delingette ◽  
...  
Keyword(s):  
Statistical Atlas ◽  
Cardiac Fibers

The generation of electric currents in cardiac fibers by Na/Ca exchange

1979 ◽  
Vol 236 (3) ◽  
pp. C103-C110 ◽  
Author(s):  
L. J. Mullins
Keyword(s):  
Membrane Potential ◽  
Duty Cycle ◽  
Action Potentials ◽  
Reversal Potential ◽  
Resting Membrane Potential ◽  
Electrochemical Gradient ◽  
Ca Current ◽  
Cardiac Action ◽  
Cardiac Fiber ◽  
Cardiac Fibers

The presence of a detectable Ca current during the excitation of a cardiac fiber implies that the Ca lost during the resting interval of the duty cycle must also be detectable. Ca outward movement appears to be effected by Na/Ca exchange when more Na enters than Ca leaves per cycle, thus making the mechanism electrogenic. Since Na/Ca exchange can move Ca either inward or outward depending on the direction of the electrochemical gradient for Na, a potential exists where there is no electric current generated by the Na/Ca exchange mechanism, i.e., a reversal potential ER. Cardiac fibers appear to have a reversal potential that is about midway between their resting membrane potential and their plateau. Carrier currents both inward and outward are therefore generated during cardiac action potentials. The implications of the conditions stated above are explored.

Comparison Between Isotropic and Anisotropic Electrical Properties of a DTI-Based Cardiac Model

2008 ◽  
Author(s):  
Ana Maria Saaibi ◽  
Isaac Chang ◽  
Min-Sig Hwang ◽  
Malisa Sarntinoranont
Keyword(s):  
Electrical Properties ◽  
Ventricular Fibrillation ◽  
Cardiac Function ◽  
Cardiac Arrhythmias ◽  
Three Dimensional ◽  
Delicate Balance ◽  
Cardiac Model ◽  
Myocardial Fibers ◽  
Fiber Organization ◽  
Cardiac Fibers

Cardiac function is influenced by the three-dimensional organization of the myocardial fibers. Cardiac fibers are arranged in a circumferential, longitudinal, and a sheet-like fashion, forming counter-wound helices from the base to the apex of the heart. This fiber organization is responsible for the delicate balance between mechanical and electrical functioning of the heart. When electrical disruption of this coordinated function occurs, this is associated with cardiac arrhythmias which may lead to more serious conditions like ventricular fibrillation.

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