Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells

immuneACCESS ◽  
2019 ◽  
Author(s):  
M Biosvert ◽  
W Zhang ◽  
EJ Elrod ◽  
NF Bernard ◽  
JP Villeneuve ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Memory B Cells ◽  
E2 Glycoprotein ◽  
Specific Memory

scholarly journals Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells

2016 ◽  
Vol 197 (12) ◽  
pp. 4848-4858 ◽  
Author(s):  
Maude Boisvert ◽  
Wanrui Zhang ◽  
Elizabeth J. Elrod ◽  
Nicole F. Bernard ◽  
Jean-Pierre Villeneuve ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Memory B Cells ◽  
E2 Glycoprotein ◽  
Specific Memory

scholarly journals A33 NOVEL E2 GLYCOPROTEIN TETRAMER DETECTS HCV-SPECIFIC MEMORY B CELLS

2018 ◽  
Vol 1 (suppl_1) ◽  
pp. 59-60
Author(s):  
M Boisvert ◽  
W Zhang ◽  
E Elrod ◽  
N Bernard ◽  
J Villeneuve ◽  
...  
Keyword(s):  
B Cells ◽  
Memory B Cells ◽  
E2 Glycoprotein ◽  
Specific Memory

scholarly journals Hepatitis C Virus Drives the Unconstrained Monoclonal Expansion of VH1–69-Expressing Memory B Cells in Type II Cryoglobulinemia: A Model of Infection-Driven Lymphomagenesis

2005 ◽  
Vol 174 (10) ◽  
pp. 6532-6539 ◽  
Author(s):  
Maurizio Carbonari ◽  
Elisabetta Caprini ◽  
Tiziana Tedesco ◽  
Francesca Mazzetta ◽  
Valeria Tocco ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Memory B Cells ◽  
Type Ii

A method for detecting hepatitis C envelope specific memory B cells from multiple genotypes using cocktail E2 tetramers

2019 ◽  
Vol 472 ◽  
pp. 65-74 ◽  
Author(s):  
Bing-Ru Wu ◽  
Auda A. Eltahla ◽  
Elizabeth Keoshkerian ◽  
Melanie R. Walker ◽  
Alex Underwood ◽  
...  
Keyword(s):  
Hepatitis C ◽  
B Cells ◽  
Memory B Cells ◽  
Specific Memory

CD4+CXCR5+ T cells activate CD27+IgG+ B cells via IL-21 in patients with hepatitis C virus infection

2016 ◽  
Vol 15 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Fan-Yun Kong ◽  
Bo Feng ◽  
Heng-Hui Zhang ◽  
Hui-Ying Rao ◽  
Jiang-Hua Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Virus Infection ◽  
Hepatitis C Virus Infection

scholarly journals Hepatitis C Virus Induces Toll-Like Receptor 4 Expression, Leading to Enhanced Production of Beta Interferon and Interleukin-6

2006 ◽  
Vol 80 (2) ◽  
pp. 866-874 ◽  
Author(s):  
Keigo Machida ◽  
Kevin T. H. Cheng ◽  
Vicky M.-H. Sung ◽  
Alexandra M. Levine ◽  
Steven Foung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
B Cells ◽  
Immune Responses ◽  
Interleukin 6 ◽  
Innate Immune ◽  
Hcv Infection ◽  
Innate Immune Responses ◽  
Altered Expression ◽  
Beta Interferon

ABSTRACT Hepatitis C virus (HCV) induces inflammatory signals, leading to hepatitis, hepatocellular carcinomas, and lymphomas. The mechanism of HCV involvement in the host's innate immune responses has not been well characterized. In this study, we analyzed expression and regulation of the entire panel of toll-like receptors (TLRs) in human B cells following HCV infection in vitro. Among all of the TLRs (TLRs 1 to 10) examined, only TLR4 showed an altered expression (a three- to sevenfold up-regulation) after HCV infection. Peripheral blood mononuclear cells from HCV-infected individuals also showed a higher expression level of TLR4 compared with those of healthy individuals. HCV infection significantly increased beta interferon (IFN-β) and interleukin-6 (IL-6) secretion from B cells, particularly after lipopolysaccharide stimulation. The increased IFN-β and IL-6 production was mediated by TLR4 induction, since the introduction of the small interfering RNA against TLR4 specifically inhibited the HCV-induced cytokine production. Among all of the viral proteins, only NS5A caused TLR4 induction in hepatocytes and B cells. NS5A specifically activated the promoter of the TLR4 gene in both hepatocytes and B cells. In conclusion, HCV infection directly induces TLR4 expression and thereby activates B cells, which may contribute to the host's innate immune responses.

scholarly journals Dissection of human humoral immune response against hepatitis C virus E2 glycoprotein by repertoire cloning and generation of recombinant fab fragments

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 810-814 ◽  
Author(s):  
Roberto Burioni ◽  
Paola Plaisant ◽  
Aldo Manzin ◽  
Domenico Rosa ◽  
Valeria Delli Carri ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Humoral Immune Response ◽  
Humoral Immune ◽  
Fab Fragments ◽  
E2 Glycoprotein

An optimized assay for the enumeration of antigen-specific memory B cells in different compartments of the human body

2010 ◽  
Vol 358 (1-2) ◽  
pp. 56-65 ◽  
Author(s):  
Yanran Cao ◽  
Maja Gordic ◽  
Sebastian Kobold ◽  
Nesrine Lajmi ◽  
Sabrina Meyer ◽  
...  
Keyword(s):  
B Cells ◽  
Human Body ◽  
Memory B Cells ◽  
Specific Memory
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