scholarly journals Dissection of human humoral immune response against hepatitis C virus E2 glycoprotein by repertoire cloning and generation of recombinant fab fragments

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 810-814 ◽  
Author(s):  
Roberto Burioni ◽  
Paola Plaisant ◽  
Aldo Manzin ◽  
Domenico Rosa ◽  
Valeria Delli Carri ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Humoral Immune Response ◽  
Humoral Immune ◽  
Fab Fragments ◽  
E2 Glycoprotein

scholarly journals Additives and Protein-DNA Combinations Modulate the Humoral Immune Response Elicited by a Hepatitis C Virus Core-encoding Plasmid in Mice

2002 ◽  
Vol 97 (1) ◽  
pp. 95-99
Author(s):  
Liz Alvarez-Lajonchere ◽  
Santiago Dueñas-Carrera ◽  
Ariel Viña ◽  
Thelvia Ramos ◽  
Dagmara Pichardo ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Humoral Immune Response ◽  
Humoral Immune ◽  
Virus Core

scholarly journals The Hepatitis C Virus Glycan Shield and Evasion of the Humoral Immune Response

Viruses ◽  
2011 ◽  
Vol 3 (10) ◽  
pp. 1909-1932 ◽  
Author(s):  
François Helle ◽  
Gilles Duverlie ◽  
Jean Dubuisson
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Humoral Immune Response ◽  
Humoral Immune

scholarly journals Humoral Immune Response in Acute Hepatitis C Virus Infection

2005 ◽  
Vol 41 (5) ◽  
pp. 667-675 ◽  
Author(s):  
D. M. Netski ◽  
T. Mosbruger ◽  
E. Depla ◽  
G. Maertens ◽  
S. C. Ray ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Humoral Immune Response ◽  
Acute Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Humoral Immune

Mucosal humoral immune response to hepatitis C virus E1/E2 surface glycoproteins and HCV shedding in saliva and cervicovaginal fluids from chronically HCV-infected patients

2003 ◽  
Vol 38 (6) ◽  
pp. 833-842 ◽  
Author(s):  
Laurent Bélec ◽  
Jérôme Legoff ◽  
Ali Si-Mohamed ◽  
Francis Bloch ◽  
François-Xavier Mbopi Keou ◽  
...  
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Humoral Immune Response ◽  
Humoral Immune ◽  
Surface Glycoproteins

scholarly journals Humoral Immune Response in Japanese Acute Hepatitis Patients with Hepatitis C Virus Infection

2000 ◽  
Vol 14 (7) ◽  
pp. 593-598 ◽  
Author(s):  
N Yamaguchi ◽  
K Tokushige ◽  
K Yamauchi ◽  
N Hayashi
Keyword(s):  
Immune Response ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Acute Hepatitis ◽  
Humoral Immune Response ◽  
Core Protein ◽  
Acute Infection ◽  
Hcv Rna ◽  
Igg Antibody ◽  
Humoral Immune

The humoral immune response to acute infection by hepatitis C virus (HCV) is not yet perfectly clear in terms of immunoglobulin (Ig) response, diversity of HCV antigen, and the relation with hepatitis severity and antibody response.  Serum IgM and IgG anti-HCV levels in patients with HCV and either acute hepatitis (AH) or fulminant hepatitis (FH) were investigated; the diversity of HCV antigen was investigated by RIBA test III.  Of 22 AH patients, 12 (54.5%) were positive for IgM anti-HCV, mainly reacting to HCV core protein. The mean interval until the appearance of IgM anti-HCV after onset was 24.1±26.2 days. IgG anti-HCV mainly reacted to both core and NS-3 antigen, appearing 42.6±42.1 days after onset.  From a serial study of 15 AH patients, it was considered that in seven AH patients (46.7%), the IgM response would precede the IgG response. In another two AH patients, IgM anti-HCV was not detected during the acute disease phase. Of 48 chronic hepatitis patients with HCV-RNA, 40 patients were positive for IgM anti-HCV.  Therefore, IgM anti-HCV was useful for diagnosis in some of the AH patients, but it was difficult to use for distinguishing between acute and chronic infection. All four FH patients with HCV-RNA were positive for both IgM and IgG antibody to HCV at onset. Their antibody titres were higher than those of AH patients. These results suggested that, as in FH due to HBV, FH due to HCV could induce strong and rapid humoral immunity.  

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