Fractional Kinetics Analysis of Pharmacological Models of Drug Distribution and Accumulation: Exact Solutions Type Multivariate Mittag-Leffler Functions

2021 ◽  
Author(s):  
Víctor F. Morales-Delgado ◽  
M. A. Taneco-Hernández ◽  
Cruz Varas-De-León ◽  
F. G. Gómez-Aguilar
Keyword(s):  
Exact Solutions ◽  
Drug Distribution ◽  
Kinetics Analysis ◽  
Fractional Kinetics

Cytopathology of Cardiac Tissue from Daunomycin-Treated Mice

1971 ◽  
Vol 29 ◽  
pp. 550-551
Author(s):  
Robert H. Liss ◽  
Frances A. Cotton
Keyword(s):  
Cardiac Tissue ◽  
Cardiac Toxicity ◽  
Drug Distribution ◽  
Personal Communication ◽  
Intravenous Dose ◽  
Single Intravenous Dose ◽  
Physiologic Saline ◽  
Histopathologic Changes ◽  
Distribution Studies ◽  
Lung And Kidney

Daunomycin, an antibiotic used in the clinical management of acute leukemia, produces a delayed, lethal cardiac toxicity. The lethality is dose and schedule dependent; histopathologic changes induced by the drug have been described in heart, lung, and kidney from hamsters in both single and multiple dose studies. Mice given a single intravenous dose of daunomycin (10 mg/kg) die 6-7 days later. Drug distribution studies indicate that the rodents excrete most of a single dose of the drug as daunomycin and metabolite within 48 hours after dosage (M. A. Asbell, personal communication).Myocardium from the ventricles of 6 moribund BDF1 mice which had received a single intravenous dose of daunomycin (10 mg/kg), and from controls dosed with physiologic saline, was fixed in glutaraldehyde and prepared for electron microscopy.

AUTORADIOGRAPHIC TECHNIQUES FOR THE LOCALIZATION OF HORMONES AND DRUGS AT THE CELLULAR AND SUBCELLULAR LEVEL

1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S205-S222 ◽  
Author(s):  
Walter E. Stumpf
Keyword(s):  
Drug Distribution ◽  
Photographic Emulsion ◽  
Frozen Sections ◽  
Hormone Research ◽  
Freeze Dried ◽  
Subcellular Level

ABSTRACT The paper describes four autoradiographic techniques which can be recommended, not without restrictions, for the study of the cellular and subcellular hormone or drug distribution in tissues. In all of the techniques desiccated slides are used which are precoated with photographic emulsion. The techniques are (I) Dry-mounting of freeze-dried sections on emulsion precoated slides; (II) Thaw-mounting of frozen sections on emulsion precoated slides; (III) Smear-mounting on emulsion precoated slides; and (IV) Touch-mounting on emulsion precoated slides. The techniques are designed to avoid or minimize translocation of the labelled molecules during preparation and during the application to photographic emulsion. Cited examples of application of these techniques demonstrate their utility in hormone research.

Processing Nigerian pyrolusite ore, Part I: Characterization and dissolution kinetics analysis

CIM Journal ◽  
2016 ◽  
Vol 7 (1) ◽  
pp. 43-51 ◽  
Author(s):  
A. A. Baba ◽  
L. Ibrahim ◽  
R. B. Bale ◽  
A. G. F. Alabi ◽  
F. A. Adekola ◽  
...  
Keyword(s):  
Dissolution Kinetics ◽  
Kinetics Analysis
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