Androgen Receptor (AR) Transcriptionally Inhibits Programmed Death Ligand-1(PD-L1) Expression to Impact Bladder Cancer Cell Immune Escape

2021 ◽  
Author(s):  
Anran Sun ◽  
Yu Luo ◽  
Wen Xiao ◽  
Zhipeng Zhu ◽  
Hongyu Yan ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Immune Escape ◽  
Bladder Cancer Cell ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

scholarly journals MP49-16 ENZALUTAMIDE INHIBITS ANDROGEN RECEPTOR-POSITIVE BLADDER CANCER CELL GROWTH

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Takashi Kawahara ◽  
Hiroki Ide ◽  
Eiji Kashiwagi ◽  
Leonardo Reis ◽  
Yichun Zheng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals

Oncotarget ◽  
2015 ◽  
Vol 6 (40) ◽  
pp. 43081-43089 ◽  
Author(s):  
ChangYi Lin ◽  
WanYing Lin ◽  
Shuyuan Yeh ◽  
Lei Li ◽  
Chawnshang Chang
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Bladder Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Histone Demethylase KDM7A Regulates Androgen Receptor Activity, and Its Chemical Inhibitor TC-E 5002 Overcomes Cisplatin-Resistance in Bladder Cancer Cells

2020 ◽  
Vol 21 (16) ◽  
pp. 5658
Author(s):  
Kyoung-Hwa Lee ◽  
Byung-Chan Kim ◽  
Seung-Hwan Jeong ◽  
Chang Wook Jeong ◽  
Ja Hyeon Ku ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Xenograft Model ◽  
Histone Demethylase ◽  
Bladder Cancer Cell ◽  
Bladder Cancer Cell Line ◽  
Mouse Xenograft Model ◽  
Bladder Cancer Cells

Histone demethylase KDM7A regulates many biological processes, including differentiation, development, and the growth of several cancer cells. Here, we have focused on the role of KDM7A in bladder cancer cells, especially under drug-resistant conditions. When the KDM7A gene was knocked down, bladder cancer cell lines showed impaired cell growth, increased cell death, and reduced rates of cell migration. Biochemical studies revealed that KDM7A knockdown in the bladder cancer cells repressed the activity of androgen receptor (AR) through epigenetic regulation. When we developed a cisplatin-resistant bladder cancer cell line, we found that AR expression was highly elevated. Upon treatment with TC-E 5002, a chemical inhibitor of KDM7A, the cisplatin-resistant bladder cancer cells, showed decreased cell proliferation. In the mouse xenograft model, KDM7A knockdown or treatment with its inhibitor reduced the growth of the bladder tumor. We also observed the upregulation of KDM7A expression in patients with bladder cancer. The findings suggest that histone demethylase KDM7A mediates the growth of bladder cancer. Moreover, our findings highlight the therapeutic potential of the KMD7A inhibitor, TC-E 5002, in patients with cisplatin-resistant bladder cancer.

Enzalutamide inhibits androgen receptor–positive bladder cancer cell growth

2016 ◽  
Vol 34 (10) ◽  
pp. 432.e15-432.e23 ◽  
Author(s):  
Takashi Kawahara ◽  
Hiroki Ide ◽  
Eiji Kashiwagi ◽  
Kareem A. El-Shishtawy ◽  
Yi Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Androgen Receptor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Bladder Cancer Cell ◽  
Cancer Cell Growth

624: Usefulness of Cancer Vaccine Therapy Using Bladder Cancer Cell Line Introduced with Interleukin 21 Gene

2006 ◽  
Vol 175 (4S) ◽  
pp. 201-201 ◽  
Author(s):  
Isao Hara ◽  
Junya Furukawa ◽  
Kazuki Yamanaka ◽  
Yuji Yamada ◽  
Masato Fujisawa
Keyword(s):  
Bladder Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Vaccine ◽  
Cancer Cell Line ◽  
Bladder Cancer Cell ◽  
Vaccine Therapy ◽  
Bladder Cancer Cell Line ◽  
Interleukin 21
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