Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma

2021 ◽  
Author(s):  
Lekshmi R Nath ◽  
Mundanattu Swetha ◽  
Vinod Vijayakurup ◽  
Arun Kumar Thangarasu ◽  
Nair Haiprasad Haritha ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chemotherapeutic Efficacy ◽  
Survival Signals

scholarly journals A Novel Expression Signature from the Perspective of Mesenchymal-Epithelial Transition for Hepatocellular Carcinoma with Regard to Prognosis, Clinicopathological Features, Immune Cell Infiltration, Chemotherapeutic Efficacy, and Immunosuppressive Molecules

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Lijun Xu ◽  
Qing Zheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Status ◽  
Immune Cell ◽  
Risk Groups ◽  
Clinicopathological Features ◽  
Low Risk ◽  
Immune Cell Infiltration ◽  
Chemotherapeutic Efficacy ◽  
Cox Analysis ◽  
Mesenchymal Epithelial Transition

Purpose. Mesenchymal-epithelial transition (MET), a reverse biological process to epithelial-mesenchymal transition (EMT), is involved in tumor metastasis and invasion. However, the role of MET-related genes (MRGs) in hepatocellular carcinoma (HCC) prognosis remains unclear. Methods. In this research, we obtained MRGs data and clinical information from public databases. In the TCGA dataset, a prognostic signature for HCC was constructed by the least absolute shrinkage and selection operator (LASSO) method and externally verified using the ICGC dataset. Results. There were 148 differentially expressed MRGs (DEMRGs), out of which 37 MRGs were found associated with overall survival (OS) in the univariate Cox analysis. A novel signature integrating of 5 MRGs was constructed, which split patients into high- and low-risk groups. Kaplan–Meier analysis revealed that high-risk patients had unfavorable OS than those low-risk counterparts. Receiver operating characteristic curve (ROC) showed great performance of this signature in predictive ability. Multivariate Cox analysis confirmed that this signature could independently predict HCC prognosis. The analysis of immune cell infiltration demonstrated that immune status varied differently between high- and low-risk groups. The analysis of clinicopathological characteristics suggested that tumor grade, clinical stage, and T stage were different between risk groups. The analysis between this signature and chemotherapeutic efficacy and immunosuppressive molecules indicated that this signature could serve as a promising predictor. Conclusions. In conclusion, we constructed and verified a novel signature from the perspective of MET, which was significantly associated with HCC prognosis, clinicopathological features, immune status, chemotherapeutic efficacy, and immunosuppressive biomarkers.

scholarly journals The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 5990-6000 ◽  
Author(s):  
Hongping Xia ◽  
Jianxiang Chen ◽  
Ming Shi ◽  
Amudha Deivasigamani ◽  
London Lucien P.J. Ooi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Over Expression ◽  
Chemotherapeutic Efficacy

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Hepatocellular carcinoma

1982 ◽  
Vol 118 (1) ◽  
pp. 69-70 ◽  
Author(s):  
A. J. Bennett
Keyword(s):  
Hepatocellular Carcinoma

Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplanation

2001 ◽  
Vol 120 (5) ◽  
pp. A90-A90
Author(s):  
N ESNAOLA ◽  
G LAUWERS ◽  
N MIRZA ◽  
D NAGORNEY ◽  
D DOHERTY ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microvascular Invasion

Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A558-A558
Author(s):  
M TAMANO ◽  
K KOJIMA ◽  
M OGUMA ◽  
M LIJIMA ◽  
T MUROHISA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Potential ◽  
Small Hepatocellular Carcinoma
Sign in / Sign up

Export Citation Format

Share Document