scholarly journals The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 5990-6000 ◽  
Author(s):  
Hongping Xia ◽  
Jianxiang Chen ◽  
Ming Shi ◽  
Amudha Deivasigamani ◽  
London Lucien P.J. Ooi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Over Expression ◽  
Chemotherapeutic Efficacy

scholarly journals Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

2014 ◽  
Author(s):  
E. Guerriero ◽  
M. Accardo ◽  
F. Capone ◽  
G. Colonna ◽  
G. Castello ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Endoplasmic Reticulum ◽  
Biological Function ◽  
Cytosolic Calcium ◽  
Human Hepatocellular Carcinoma ◽  
Over Expression ◽  
The Common ◽  
Selenoprotein M ◽  
Putative Marker ◽  
First Time

Selenium is an essential trace mineral of fundamental importance to human healthy and exerts its biological function through selenoproteins. In particular, Selenoprotein M (SELM) is located in the endoplasmic reticulum and contains the common redox motif of cysteine-X-X-selenocysteine type. It attracts great attention due to its high expression in brain and its potential roles as antioxidant, neuroprotective, and cytosolic calcium regulator. Recently, our group found SELM over-expression  in human hepatocellular carcinoma (HCC) cell lines. In this report some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC were immunohistochemically stained and SELM expression scoring was evaluated. Our results evidence for the first time an increase of SELM expression in HCC liver tissues, and its gradual expression raise associated with an increased malignancy grade. Therefore, we propose to use i) SELM as putative marker for HCC as well as ii) simple immunohistochemistry technique to distinguish between the different grades of malignancy. 

834 Functional consequences of frizzled-7 receptor over-expression in human hepatocellular carcinoma

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 564-564
Author(s):  
P MERLE ◽  
S DELAMONTE ◽  
M HERRMANN ◽  
S TANAKA ◽  
M KIM ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Over Expression ◽  
Functional Consequences

Over-expression of Smac promotes TRAIL-induced cell death in human hepatocellular carcinoma

2003 ◽  
Author(s):  
Hiroshi Okano ◽  
Katsuya Shiraki ◽  
Hidekazu Inoue ◽  
Tomoyuki Kawakita ◽  
Yukiko Saitou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Human Hepatocellular Carcinoma ◽  
Over Expression
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