Enantioseparation and Determination of Sulcoanzole Enantiomers in Rat Plasma and Tissues by Chiral HPLC-ESI-MS/MS Method Coupled with SPE Procedure and Its Application to the Studies on Stereoselective Pharmacokinetics and Tissue Distribution

2021 ◽  
Author(s):  
Siman Ma ◽  
Lina Wang ◽  
Guoxian Guo ◽  
Jing Tang ◽  
Jia Yu
Keyword(s):  
Tissue Distribution ◽  
Rat Plasma ◽  
Chiral Hplc ◽  
Esi Ms ◽  
Stereoselective Pharmacokinetics

Solid phase extraction procedure coupled with the chiral LC-ESI-MS/MS method for the enantioseparation and determination of butoconazole enantiomers in rat plasma and tissues: application to the enantioselective study on pharmacokinetics and tissue distribution

2021 ◽  
Author(s):  
Siman Ma ◽  
Lina Wang ◽  
Guoxian Guo ◽  
Jia Yu ◽  
Xingjie Guo
Keyword(s):  
Solid Phase Extraction ◽  
Tissue Distribution ◽  
Solid Phase ◽  
Extraction Procedure ◽  
Rat Plasma ◽  
Phase Extraction ◽  
Esi Ms ◽  
Solid Phase Extraction Procedure ◽  
Chiral Lc

A significant enantioselective difference between (−)- and (+)-butoconazole existed in the stage of not only pharmacokinetics but also tissue distribution.

Enantioselective LC‐ESI‐MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study

2018 ◽  
Vol 33 (3) ◽  
pp. e4434 ◽  
Author(s):  
Narayanan Balaji ◽  
Bhavesh Babulal Gabani ◽  
Umesh Todmal ◽  
Suresh P. Sulochana ◽  
Neeraj Kumar Saini ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Esi Ms

Development and validation of a LC-ESI–MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics

2011 ◽  
Vol 879 (19) ◽  
pp. 1653-1658 ◽  
Author(s):  
Hong-Liang Li ◽  
Xiao-Jin Peng ◽  
Jian-Chang He ◽  
En-Fu Feng ◽  
Gui-Li Xu ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Esi Ms ◽  
Development And Validation

Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC–ESI-MS/MS and its application in pharmacokinetic study

2012 ◽  
Vol 907 ◽  
pp. 27-33 ◽  
Author(s):  
Ying-yi Li ◽  
Ye-ying Song ◽  
Chang-hui Liu ◽  
Xiao-tao Huang ◽  
Xia Zheng ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Esi Ms
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