Rapid determination of rat plasma uridine levels by HPLC-ESI-MS utilizing the Captiva? filter plates for sample preparation

2003 ◽  
Vol 17 (4) ◽  
pp. 215-218 ◽  
Author(s):  
Marta G. Williams ◽  
Joe Palandra ◽  
Eric M. Shobe
Keyword(s):  
Sample Preparation ◽  
Rapid Determination ◽  
Rat Plasma ◽  
Esi Ms

Enantioselective LC‐ESI‐MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study

2018 ◽  
Vol 33 (3) ◽  
pp. e4434 ◽  
Author(s):  
Narayanan Balaji ◽  
Bhavesh Babulal Gabani ◽  
Umesh Todmal ◽  
Suresh P. Sulochana ◽  
Neeraj Kumar Saini ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Esi Ms

Development and validation of a LC-ESI–MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics

2011 ◽  
Vol 879 (19) ◽  
pp. 1653-1658 ◽  
Author(s):  
Hong-Liang Li ◽  
Xiao-Jin Peng ◽  
Jian-Chang He ◽  
En-Fu Feng ◽  
Gui-Li Xu ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Esi Ms ◽  
Development And Validation

Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC–ESI-MS/MS and its application in pharmacokinetic study

2012 ◽  
Vol 907 ◽  
pp. 27-33 ◽  
Author(s):  
Ying-yi Li ◽  
Ye-ying Song ◽  
Chang-hui Liu ◽  
Xiao-tao Huang ◽  
Xia Zheng ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Esi Ms

A sensitive HPLC-FL method to simultaneously determine febuxostat and diclofenac in rat plasma: assessment of metabolic drug interactions in vitro and in vivo

2020 ◽  
Vol 12 (16) ◽  
pp. 2166-2175 ◽  
Author(s):  
Dong-Gyun Han ◽  
Kyu-Sang Kim ◽  
Seong-Wook Seo ◽  
Young Mee Baek ◽  
Yunjin Jung ◽  
...  
Keyword(s):  
Sample Preparation ◽  
Drug Interactions ◽  
Simultaneous Determination ◽  
Small Volume ◽  
Rat Plasma ◽  
Metabolic Drug ◽  
Simple Sample Preparation

We developed a sensitive, simple and validated HPLC-FL method for simultaneous determination of FEB and DIC in rat plasma. The method requires a relatively small volume of sample, has simple sample preparation and excellent sensitivity.

scholarly journals Rapid Determination of Isomeric Benzoylpaeoniflorin and Benzoylalbiflorin in Rat Plasma by LC-MS/MS Method

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Chuanqi Zhou ◽  
Xiaoke Wang
Keyword(s):  
Linear Response ◽  
Therapeutic Agent ◽  
Rapid Determination ◽  
Rat Plasma ◽  
Mass Spectrometric ◽  
Tandem Mass ◽  
Liquid Chromatography Tandem Mass ◽  
Bioanalytical Application ◽  
Tandem Mass Spectrometric

Benzoylpaeoniflorin (BP) is a potential therapeutic agent against oxidative stress related Alzheimer’s disease. In this study, a more rapid, selective, and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed to determine BP in rat plasma distinguishing with a monoterpene isomer, benzoylalbiflorin (BA). The method showed a linear response from 1 to 1000 ng/mL (r>0.9950). The precision of the interday and intraday ranged from 2.03 to 12.48% and the accuracy values ranged from −8.00 to 10.33%. Each running of the method could be finished in 4 minutes. The LC-MS/MS method was validated for specificity, linearity, precision, accuracy, recovery, and stability and was found to be acceptable for bioanalytical application. Finally, this fully validated method was successfully applied to a pharmacokinetic study in rats following oral administration.

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