Phenylboronic Ester -Modified Polymeric Nanoparticles for Promoting TRP2 Peptide Antigen Delivery in Cancer Immunotherapy

2021 ◽  
Author(s):  
Qi Y. Wang ◽  
Zhipeng Dong ◽  
Wei X. Liu ◽  
Bo N. Zhao ◽  
Han N. Wen ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Polymeric Nanoparticles ◽  
Antigen Delivery ◽  
Peptide Antigen

Rational design and evaluation of HBsAg polymeric nanoparticles as antigen delivery carriers

2018 ◽  
Vol 111 ◽  
pp. 804-812 ◽  
Author(s):  
Hitesh Kumar Dewangan ◽  
Tarun Pandey ◽  
Lakshmi Maurya ◽  
Sanjay Singh
Keyword(s):  
Rational Design ◽  
Polymeric Nanoparticles ◽  
Antigen Delivery

scholarly journals Advances in Engineered Polymer Nanoparticle Tracking Platforms towards Cancer Immunotherapy—Current Status and Future Perspectives

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 935
Author(s):  
Ramar Thangam ◽  
Kapil D. Patel ◽  
Heemin Kang ◽  
Ramasamy Paulmurugan
Keyword(s):  
Cancer Immunotherapy ◽  
Anticancer Agents ◽  
Polymeric Nanoparticles ◽  
Current Status ◽  
Polymeric Nanocarriers ◽  
Therapeutic Drugs ◽  
Small Molecule Ligands ◽  
Recent Developments ◽  
Cancer Immunotherapies

Engineering polymeric nanoparticles for their shape, size, surface chemistry, and functionalization using various targeting molecules has shown improved biomedical applications for nanoparticles. Polymeric nanoparticles have created tremendous therapeutic platforms, particularly applications related to chemo- and immunotherapies in cancer. Recently advancements in immunotherapies have broadened this field in immunology and biomedical engineering, where “immunoengineering” creates solutions to target translational science. In this regard, the nanoengineering field has offered the various techniques necessary to manufacture and assemble multifunctional polymeric nanomaterial systems. These include nanoparticles functionalized using antibodies, small molecule ligands, targeted peptides, proteins, and other novel agents that trigger and encourage biological systems to accept the engineered materials as immune enhancers or as vaccines to elevate therapeutic functions. Strategies to engineer polymeric nanoparticles with therapeutic and targeting molecules can provide solutions for developing immune vaccines via maintaining the receptor storage in T- and B cells. Furthermore, cancer immunotherapy using polymeric nanomaterials can serve as a gold standard approach for treating primary and metastasized tumors. The current status of the limited availability of immuno-therapeutic drugs highlights the importance of polymeric nanomaterial platforms to improve the outcomes via delivering anticancer agents at localized sites, thereby enhancing the host immune response in cancer therapy. This review mainly focuses on the potential scientific enhancements and recent developments in cancer immunotherapies by explicitly discussing the role of polymeric nanocarriers as nano-vaccines. We also briefly discuss the role of multifunctional nanomaterials for their therapeutic impacts on translational clinical applications.

scholarly journals Nanovaccines against Animal Pathogens: The Latest Findings

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 988
Author(s):  
Carmen Teresa Celis-Giraldo ◽  
Julio López-Abán ◽  
Antonio Muro ◽  
Manuel Alfonso Patarroyo ◽  
Raúl Manzano-Román
Keyword(s):  
Vaccine Development ◽  
Polymeric Nanoparticles ◽  
Cost Effective ◽  
Antigen Delivery ◽  
Emerging Pathogens ◽  
Persistent Infections ◽  
Self Assembling ◽  
Animal Pathogens ◽  
Novel Delivery Systems ◽  
Encapsulation Ability

Nowadays, safe and efficacious vaccines represent powerful and cost-effective tools for global health and economic growth. In the veterinary field, these are undoubtedly key tools for improving productivity and fighting zoonoses. However, cases of persistent infections, rapidly evolving pathogens having high variability or emerging/re-emerging pathogens for which no effective vaccines have been developed point out the continuing need for new vaccine alternatives to control outbreaks. Most licensed vaccines have been successfully used for many years now; however, they have intrinsic limitations, such as variable efficacy, adverse effects, and some shortcomings. More effective adjuvants and novel delivery systems may foster real vaccine effectiveness and timely implementation. Emerging vaccine technologies involving nanoparticles such as self-assembling proteins, virus-like particles, liposomes, virosomes, and polymeric nanoparticles offer novel, safe, and high-potential approaches to address many vaccine development-related challenges. Nanotechnology is accelerating the evolution of vaccines because nanomaterials having encapsulation ability and very advantageous properties due to their size and surface area serve as effective vehicles for antigen delivery and immunostimulatory agents. This review discusses the requirements for an effective, broad-coverage-elicited immune response, the main nanoplatforms for producing it, and the latest nanovaccine applications for fighting animal pathogens.

scholarly journals The Utility of Poly(γ-glutamic acid) Nanoparticles as Antigen Delivery Carriers in Dendritic Cell-Based Cancer Immunotherapy

2010 ◽  
Vol 33 (12) ◽  
pp. 2003-2007 ◽  
Author(s):  
Keisuke Matsuo ◽  
Yumiko Ishii ◽  
Kazuhiko Matsuo ◽  
Tomoyo Yoshinaga ◽  
Mitsuru Akashi ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Glutamic Acid ◽  
Cancer Immunotherapy ◽  
Antigen Delivery
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