scholarly journals Design of pH-sensitive polymer-based antigen delivery systems for cancer immunotherapy

2015 ◽  
Vol 30 (2) ◽  
pp. 160-161
Author(s):  
Eiji Yuba
Keyword(s):  
Cancer Immunotherapy ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Antigen Delivery ◽  
Ph Sensitive Polymer ◽  
Antigen Delivery Systems

The application of pH-sensitive polymer-lipids to antigen delivery for cancer immunotherapy

Biomaterials ◽  
2013 ◽  
Vol 34 (22) ◽  
pp. 5711-5721 ◽  
Author(s):  
Eiji Yuba ◽  
Yoshikazu Kono ◽  
Atsushi Harada ◽  
Shoichi Yokoyama ◽  
Masaya Arai ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Ph Sensitive ◽  
Antigen Delivery ◽  
Ph Sensitive Polymer

Potentiation of pH-sensitive polymer-modified liposomes with cationic lipid inclusion as antigen delivery carriers for cancer immunotherapy

Biomaterials ◽  
2014 ◽  
Vol 35 (28) ◽  
pp. 8186-8196 ◽  
Author(s):  
Yuta Yoshizaki ◽  
Eiji Yuba ◽  
Naoki Sakaguchi ◽  
Kazunori Koiwai ◽  
Atsushi Harada ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Cationic Lipid ◽  
Ph Sensitive ◽  
Antigen Delivery ◽  
Lipid Inclusion ◽  
Ph Sensitive Polymer

scholarly journals Implantable vaccines: a solution for immune system manipulation to any antigenic stimulus

2020 ◽  
Vol 4 (4) ◽  
pp. 5-11
Author(s):  
Ioanna Zerva ◽  
Vasileia Pateraki ◽  
Irene Athanassakis
Keyword(s):  
Immune Response ◽  
Ex Vivo ◽  
Great Majority ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Immune Responsiveness ◽  
Antigenic Stimulus ◽  
Human Pathology ◽  
Check Points ◽  
Antigen Delivery Systems

Effective and side-effect-free vaccines are still difficult tasks to achieve for a great majority of antigenic stimuli. Pathogen manipulation to abort infectivity and antigen delivery to ensure immune responsiveness are the major components vaccine technology tries to resolve. However, the development of an immune response is still a complicated matter, lies on hundreds of parameters and any effort towards activation can easily lead to adverse effects, making immunotherapy very difficult to control. The present review attempts to highlight the major parameters affecting immune responsiveness and show that vaccine technology, except from pathogen manipulation and the development of antigen delivery systems, requires attention to additional check-points. Analyzing the recently described personalized implantable vaccine technology, it becomes obvious that the nature of each antigenic stimulus dictates different responsiveness to the organism, which discourages the use of universal adjuvant and antigen-delivery systems. On the contrary, the ex vivo tuning of the immune response proposed by the implantable vaccine technology, allows controllable amendment of the response. The development of personalized technologies is expected to provide valuable tools for the management of human pathology.

Sign in / Sign up

Export Citation Format

Share Document