Substrate Rigidity Dictates Colorectal Tumorigenic Cell Stemness and Metastasis via KIAA1211 Dependent Mechanotransduction

2021 ◽  
Author(s):  
Yuhan Chang ◽  
Juan Zhang ◽  
Xinying Huo ◽  
Xinliang Qu ◽  
Chunlei Xia ◽  
...  
Keyword(s):  
Substrate Rigidity ◽  
Tumorigenic Cell

A tumorigenic cell line derived from a hamster cholangiocarcinoma associated with Opisthorchis felineus liver fluke infection

Life Sciences ◽  
2021 ◽  
pp. 119494
Author(s):  
Viatcheslav A. Mordvinov ◽  
Galina A. Minkova ◽  
Anna V. Kovner ◽  
Dmitriy V. Ponomarev ◽  
Maria N. Lvova ◽  
...  
Keyword(s):  
Cell Line ◽  
Liver Fluke ◽  
Opisthorchis Felineus ◽  
Fluke Infection ◽  
Liver Fluke Infection ◽  
Tumorigenic Cell Line ◽  
Tumorigenic Cell

scholarly journals Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

2009 ◽  
Vol 218 (2) ◽  
pp. 285-293 ◽  
Author(s):  
Tae-Jin Kim ◽  
Jihye Seong ◽  
Mingxing Ouyang ◽  
Jie Sun ◽  
Shaoying Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Substrate Rigidity

scholarly journals Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons

2012 ◽  
Vol 102 (3) ◽  
pp. 452-460 ◽  
Author(s):  
Daniel Koch ◽  
William J. Rosoff ◽  
Jiji Jiang ◽  
Herbert M. Geller ◽  
Jeffrey S. Urbach
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Cone ◽  
Substrate Rigidity

ESTABLISHED TUMORIGENIC CELL LINES FROM A SPONTANEOUS MURINE (VM/Dk) ASTROCYTOMA (SMA)

1978 ◽  
Vol 37 (5) ◽  
pp. 689 ◽  
Author(s):  
R. D. Serano ◽  
C. N. Pegram ◽  
H. Fraser ◽  
A. G. Dickinson ◽  
D. D. Bigner
Keyword(s):  
Cell Lines ◽  
Tumorigenic Cell

The Wear Characteristics of Graphene as an Atomically-Thin Protective Coating

2012 ◽  
Author(s):  
Emil Sandoz-Rosado ◽  
Elon J. Terrell
Keyword(s):  
Protective Coatings ◽  
Solid Lubricants ◽  
Atomistic Simulations ◽  
Great Promise ◽  
Load Carrying Capacity ◽  
Sliding Velocity ◽  
Substrate Rigidity ◽  
Macro Scale ◽  
Load Carrying ◽  
The Impact

Lamellar atomically-thin sheets such as graphene (and its bulk equivalent graphite) and molybdenum disulfide have emerged as excellent solid lubricants at the macro scale and show great promise as protective coatings for nanoscopic applications. In this study, the failure mechanisms of graphene under sliding are examined using atomistic simulations. An atomic tip is slid over a graphene membrane that is adhered to a semi-infinite substrate. The impact of sliding velocity and substrate rigidity on the wear and frictional behavior of graphene is studied. In addition, the interplay of adhesive and abrasive wear on the graphene coating is also examined. The preliminary results indicate that graphene has excellent potential as a nanoscale due to its atomically-thin configuration and high load carrying capacity.

Study of Cellular Adhesion by Means of Micropillar Surface Topologies

2011 ◽  
Vol 409 ◽  
pp. 105-110 ◽  
Author(s):  
Francesca Boccafoschi ◽  
Marco Rasponi ◽  
Cecilia Mosca ◽  
Erica Bocchi ◽  
Simone Vesentini
Keyword(s):  
Focal Adhesion ◽  
Vascular Tissue ◽  
Focal Adhesions ◽  
Traction Force ◽  
Cellular Adhesion ◽  
Research Field ◽  
Traction Forces ◽  
Adhesion Sites ◽  
Substrate Rigidity ◽  
Open Question

It is well-known that cellular behavior can be guided by chemical signals and physical interactions at the cell-substrate interface. The patterns that cells encounter in their natural environment include nanometer-to-micrometer-sized topographies comprising extracellular matrix, proteins, and adjacent cells. Whether cells transduce substrate rigidity at the microscopic scale (for example, sensing the rigidity between adhesion sites) or the nanoscopic scale remains an open question. Here we report that micromolded elastomeric micropost arrays can decouple substrate rigidity from adhesive and surface properties. Arrays of poly (dimethylsiloxane) (PDMS) microposts from microfabricated silicon masters have been fabricated. To control substrate rigidity they present the same post heights but different surface area and spacing between posts. The main advantage of micropost arrays over other surface modification solutions (i.e. hydrogels) is that measured subcellular traction forces could be attributed directly to focal adhesions. This would allow to map traction forces to individual focal adhesions and spatially quantify subcellular distributions of focal-adhesion area, traction force and focal-adhesion stress. Moreover, different adhesion intracellular pathways could be used by the cells to differentiate toward a proliferative or a contractile cellular phenotype, for instance. This particular application is advantageous for vascular tissue engineering applications, where mimicking as close as possible the vessels dynamics should be a step forward in this research field.

A Model for Analyzing Multi-Asperity Contact of Thin Sheets With Real Surfaces on Both Sides

2005 ◽  
Author(s):  
John J. Jagodnik ◽  
Sinan Mu¨ftu¨
Keyword(s):  
Thin Sheet ◽  
Beam Theory ◽  
Contact Problems ◽  
Elastic Half Space ◽  
Asperity Contact ◽  
Thin Sheets ◽  
Bending Rigidity ◽  
Bernoulli Beam ◽  
Substrate Rigidity ◽  
Euler Bernoulli Beam

A model for two-sided contact of a thin sheet of material, with real surfaces on both sides is presented. The model combines cylindrical-contact equations, with Euler-Bernoulli beam theory to examine the importance of substrate rigidity in two-sided contact problems. A finite difference program for solving this model is developed. Results for two-sided contact of numerically generated surfaces on thin tapes are presented. The effects of tape thickness and tension are explored. It is shown that substrate’s bending rigidity contributes significantly to the overall equilibrium, for typical tape thicknesses and tension values used by the industry. However, large thickness values exists for which substrate bending is negligible and elastic half-space solutions applied to both sides of the tape are adequate.

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