Temperature-Responsive Biodegradable Injectable Polymers Having Tissue Adhesive Properties for Biomedical Materials

2021 ◽  
Author(s):  
Soichiro Fujiwara ◽  
Yuta Yoshizaki ◽  
Akinori Kuzuya ◽  
Yuichi Ohya
Keyword(s):  
Tissue Adhesive ◽  
Adhesive Properties ◽  
Biomedical Materials ◽  
Temperature Responsive ◽  
Injectable Polymers

First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties

2019 ◽  
Vol 11 (41) ◽  
pp. 38232-38239 ◽  
Author(s):  
Daniel Bermejo-Velasco ◽  
Sandeep Kadekar ◽  
Marcus Vinicius Tavares da Costa ◽  
Oommen P. Oommen ◽  
Kristofer Gamstedt ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tissue Adhesive ◽  
Adhesive Properties ◽  
Hyaluronic Acid Hydrogel

Rapid in situ cross-linking of hydrogel adhesives based on thiol-grafted bio-inspired catechol-conjugated chitosan

2017 ◽  
Vol 32 (5) ◽  
pp. 612-621 ◽  
Author(s):  
Zhiwen Zeng ◽  
Xiumei Mo
Keyword(s):  
Soft Tissues ◽  
Sodium Periodate ◽  
Oxidation Mechanism ◽  
Thiol Group ◽  
In Vitro Cytotoxicity ◽  
Tissue Adhesive ◽  
Molar Ratio ◽  
Adhesive Properties

In this paper, a novel chitosan derivative, thiol-grafting bio-inspired catechol-conjugated chitosan was synthesized. The chemical structure of the synthesized catechol-conjugated chitosan was verified by 1H NMR, and its contents of thiol group and catechol group were determined by UV-vis spectrum. Four percent of catechol-conjugated chitosan aqueous solution could form hydrogels rapidly in situ in 1 min or less with the addition of sodium periodate. Rheological studies showed that the mechanical properties depend on the concentrations of catechol-conjugated chitosan and the molar ratio of sodium periodate to catechol groups. Additionally, the adhesive properties of the resulting adhesives were evaluated, and the adhesion strength of obtained adhesives was as high as 50 kPa because of the complex and multiple interactions, especially the anti-oxidation mechanism of thiol group. The in vitro cytotoxicity assays demonstrated an excellent biocompatibility of the catechol-conjugated chitosan hydrogels. Benefiting from the in situ fast cured, desired mechanical strength, biocompatibility and relatively high adhesion performance, these properties suggested that catechol-conjugated chitosan hydrogel adhesives have potential applications as tissue adhesive for soft tissues.

Physical and Adhesive Properties of Cyanoacrylate-Based β-TCP Composites

2007 ◽  
Vol 330-332 ◽  
pp. 419-422 ◽  
Author(s):  
G.S. Lee ◽  
Sang Bae Lee ◽  
Doug Youn Lee ◽  
Kyeong Jun Park ◽  
S.O. Kim ◽  
...  
Keyword(s):  
Compressive Strength ◽  
Citric Acid ◽  
Bond Strength ◽  
Shear Bond Strength ◽  
Setting Time ◽  
Tissue Adhesive ◽  
Adhesive Properties ◽  
Composite Systems ◽  
Filling Materials

Histoacryl® (N-butyl-2-cyanoacrylate) has been widely utilized as a tissue adhesive. The aim of this study was to evaluate the physical and adhesive properties of newly developed cyanoacrylate-based β-TCP composite systems. The β-TCP powder was modified on the surface with citric acid to make this material mixed with cyanoacrylate easily. The setting time of acidtreated β-TCP/ Histoacryl® systems was dramatically prolonged and the polymerization heat was significantly decreased compared to that of untreated β-TCP/Histoacryl® system. The shear bond strength of cyanoacrylate-based β-TCP composites decreased with addition of acid-treated β-TCP filler. The compressive strength of β-TCP/Histoacryl® composites increased strongly with increasing the amount of acid-treated β-TCP filler. The cytotoxicity of the β-TCP/Histoacryl® composites decreased with the increasing of the amount of added β-TCP. These results indicated that our novel β-TCP/Histoacryl® composites had the great potential to serve as adhesives or filling materials in the dental field.

Study on Bone Cell Adaptability of α-TCP/HAp Functionally Graded Porous Beads for Biomaterials Application

2010 ◽  
Vol 76 ◽  
pp. 143-146
Author(s):  
S. Ohtake ◽  
T. Asaoka ◽  
K. Furukawa ◽  
T. Ushida ◽  
T. Tateishi
Keyword(s):  
Bone Cells ◽  
High Strength ◽  
Bone Cell ◽  
Functionally Graded ◽  
The Body ◽  
Tissue Adhesive ◽  
Adhesive Properties ◽  
Living Body ◽  
Porous Beads

Porous beads of bioactive ceramics such as HAp, TCP are considered to be promising as excellent scaffolds for cultivating bone cells. To realize this type of beads which maintains the function of scaffold with sufficient strength up to growth of new bone, and is expected to absorbed completely after the growth, a-TCP/ HAp functionally graded porous beads were fabricated. HAp is bioactive material which has both high strength and better tissue-adhesive properties, but that is not readily absorbed by the human body. On the contrary, a-TCP is highly bioabsorbable; it is quickly absorbed by the body, and, therefore, disappears before bone is completely replaced. Fabricated new beads are composed of a-TCP at the center and HAp at the surface, to control the solubility in living body. Bone cell adaptability of these beads were confirmed in vitro.

Tunable and high tissue adhesive properties of injectable chitosan based hydrogels through polymer architecture modulation

2021 ◽  
Vol 261 ◽  
pp. 117810
Author(s):  
Ha Young Jung ◽  
Phuong Le Thi ◽  
Kyung-Hee HwangBo ◽  
Jin Woo Bae ◽  
Ki Dong Park
Keyword(s):  
Tissue Adhesive ◽  
Polymer Architecture ◽  
Adhesive Properties

Solubility Control of αTCP-HAp Functionally Graded Porous Beads in SBF for Biomaterial Use

2010 ◽  
Vol 638-642 ◽  
pp. 2021-2027
Author(s):  
Teruo Asaoka ◽  
Yuji Kajihata ◽  
Katsuko Furukawa ◽  
Takashi Ushida ◽  
Tetsuya Tateishi
Keyword(s):  
Body Fluid ◽  
Absorption Rate ◽  
Bone Cells ◽  
High Strength ◽  
Functionally Graded ◽  
The Body ◽  
Tissue Adhesive ◽  
Adhesive Properties ◽  
Living Body ◽  
Porous Beads

As excellent scaffolds for cultivating bone cells, porous beads of bioactive ceramics such as HAp, TCP are considered to be promising. HAp and α-TCP are well known as non-toxic bioceramics to human cells, but their behavior in living body fluid are different. HAp is bioactive material which has both high strength and better tissue-adhesive properties, but that is not readily absorbed by the human body. On the contrary, α-TCP is highly bioabsorbable; it is quickly absorbed by the body, and, therefore, disappears before bone is completely replaced. To realize a composite which has suitable solubility in living body fluid, α-TCP/ HAp functionally graded porous beads were fabricated by the method of spheroidization in liquid nitrogen. This type of composite maintains the function of scaffold with sufficient strength up to growth of new bone, and after the growth, it is expected to absorbed completely in the body. In the present study, ceramic beads with α-TCP at the center were fabricated and coated with a functionally graded layer of HAp. By controlling the thickness of HAp layer, which could be realized by changing time of hydrolytic reaction, the absorption rate into the body would be easily controlled. In addition, to accelerate the formation of porous structure, some acid solutions were used to dissolve the beads surface and to penetrate pores toward inside of the beads. Observed surface and inner structure by SEM, also the measured change in absorption rate will be presented.

Temperature-responsive compounds as in situ gelling biomedical materials

2012 ◽  
Vol 41 (14) ◽  
pp. 4860 ◽  
Author(s):  
Hyo Jung Moon ◽  
Du Young Ko ◽  
Min Hee Park ◽  
Min Kyung Joo ◽  
Byeongmoon Jeong
Keyword(s):  
Biomedical Materials ◽  
Temperature Responsive ◽  
In Situ Gelling
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