PDGF Signaling Promotes Mitophagy in Glioblastoma Stem Cells Through N 6-Methyladenosine

2021 ◽  
Author(s):  
Deguan Lv ◽  
Ryan C. Gimple ◽  
Cuiqing Zhong ◽  
Qiulian Wu ◽  
Kailin Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Stem Cells ◽  
Pdgf Signaling

Targeted Delivery of Tumor Suppressor microRNA-1 by Transferrin- Conjugated Lipopolyplex Nanoparticles to Patient-Derived Glioblastoma Stem Cells

2014 ◽  
Vol 15 (9) ◽  
pp. 839-846 ◽  
Author(s):  
Xinmei Wang ◽  
Xiaomeng Huang ◽  
Zhaogang Yang ◽  
Daniel Gallego-Perez ◽  
Junyu Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tumor Suppressor ◽  
Targeted Delivery ◽  
Glioblastoma Stem Cells

scholarly journals DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

2021 ◽  
Vol 22 (8) ◽  
pp. 4011
Author(s):  
Brianna Chen ◽  
Dylan McCuaig-Walton ◽  
Sean Tan ◽  
Andrew P. Montgomery ◽  
Bryan W. Day ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Critical Role ◽  
Stem Cell Differentiation ◽  
Neural Progenitor Cell ◽  
Cellular Heterogeneity ◽  
Differentiation Potential ◽  
Glioblastoma Stem Cells ◽  
Glioblastoma Stem Cell

Glioblastoma display vast cellular heterogeneity, with glioblastoma stem cells (GSCs) at the apex. The critical role of GSCs in tumour growth and resistance to therapy highlights the need to delineate mechanisms that control stemness and differentiation potential of GSC. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) regulates neural progenitor cell differentiation, but its role in cancer stem cell differentiation is largely unknown. Herein, we demonstrate that DYRK1A kinase is crucial for the differentiation commitment of glioblastoma stem cells. DYRK1A inhibition insulates the self-renewing population of GSCs from potent differentiation-inducing signals. Mechanistically, we show that DYRK1A promotes differentiation and limits stemness acquisition via deactivation of CDK5, an unconventional kinase recently described as an oncogene. DYRK1A-dependent inactivation of CDK5 results in decreased expression of the stemness gene SOX2 and promotes the commitment of GSC to differentiate. Our investigations of the novel DYRK1A-CDK5-SOX2 pathway provide further insights into the mechanisms underlying glioblastoma stem cell maintenance.

MerTK activity is not necessary for the proliferation of glioblastoma stem cells

2021 ◽  
Vol 186 ◽  
pp. 114437
Author(s):  
Monira Hoque ◽  
Siu Wai Wong ◽  
Ariadna Recasens ◽  
Ramzi Abbassi ◽  
Nghi Nguyen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Stem Cells

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

2018 ◽  
Vol 34 (6) ◽  
pp. 425-440 ◽  
Author(s):  
Yoichiro Kawamura ◽  
Jun Takouda ◽  
Koji Yoshimoto ◽  
Kinichi Nakashima
Keyword(s):  
Stem Cells ◽  
Glioblastoma Multiforme ◽  
Glioblastoma Stem Cells

1406 POSTER DISCUSSION Live Image Based Screen on Glioblastoma Stem Cells

2011 ◽  
Vol 47 ◽  
pp. S171
Author(s):  
D. Danovi ◽  
A. Folarin ◽  
S. Pollard
Keyword(s):  
Stem Cells ◽  
Glioblastoma Stem Cells ◽  
Live Image

scholarly journals Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells

Glia ◽  
2014 ◽  
Vol 62 (10) ◽  
pp. 1687-1698 ◽  
Author(s):  
Yun Bai ◽  
Justin D. Lathia ◽  
Peisu Zhang ◽  
William Flavahan ◽  
Jeremy N. Rich ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Targeting ◽  
Glioblastoma Stem Cells

scholarly journals Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0172884 ◽  
Author(s):  
Julia Pollak ◽  
Karan G. Rai ◽  
Cory C. Funk ◽  
Sonali Arora ◽  
Eunjee Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ion Channel ◽  
Expression Patterns ◽  
Glioblastoma Stem Cells ◽  
Therapeutic Implications ◽  
Channel Expression

PH-0167 MRI features correlate with a molecular signature in glioblastoma stem cells

2021 ◽  
Vol 161 ◽  
pp. S102-S103
Author(s):  
F. Eckert ◽  
K. Ganser ◽  
N. Stransky ◽  
B. Bender ◽  
J. Schittenhelm ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Signature ◽  
Glioblastoma Stem Cells ◽  
Mri Features
Sign in / Sign up

Export Citation Format

Share Document