Adaptive Immune Response to Mycobacterium abscessus Complex and Cross-Reactivity of BCG Vaccination

2021 ◽  
Author(s):  
Renan Marrichi Mauch ◽  
Peter Østrup Jensen ◽  
Tavs Qvist ◽  
Mette Kolpen ◽  
Claus Moser ◽  
...  
Keyword(s):  
Immune Response ◽  
Adaptive Immune Response ◽  
Cross Reactivity ◽  
Mycobacterium Abscessus ◽  
Bcg Vaccination ◽  
Adaptive Immune

scholarly journals Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

2017 ◽  
Vol 413 ◽  
pp. 34-49 ◽  
Author(s):  
Ada W.C. Yan ◽  
Pengxing Cao ◽  
Jane M. Heffernan ◽  
Jodie McVernon ◽  
Kylie M. Quinn ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza Infection ◽  
Adaptive Immune Response ◽  
Cross Reactivity ◽  
Adaptive Immune

scholarly journals Stochastic Model of the Adaptive Immune Response Predicts Disease Severity and Captures Enhanced Cross-Reactivity in Natural Dengue Infections

2021 ◽  
Vol 12 ◽  
Author(s):  
Hung D. Nguyen ◽  
Sidhartha Chaudhury ◽  
Adam T. Waickman ◽  
Heather Friberg ◽  
Jeffrey R. Currier ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Stochastic Model ◽  
Disease Severity ◽  
Secondary Infection ◽  
Severe Disease ◽  
Adaptive Immune Response ◽  
Cross Reactivity ◽  
Adaptive Immune ◽  
Severe Manifestation

The dengue virus circulates as four distinct serotypes, where a single serotype infection is typically asymptomatic and leads to acquired immunity against that serotype. However, the developed immunity to one serotype is thought to underlie the severe manifestation of the disease observed in subsequent infections from a different serotype. We developed a stochastic model of the adaptive immune response to dengue infections. We first delineated the mechanisms initiating and sustaining adaptive immune responses during primary infections. We then contrasted these immune responses during secondary infections of either a homotypic or heterotypic serotype to understand the role of pre-existing and reactivated immune pathways on disease severity. Comparison of non-symptomatic and severe cases from heterotypic infections demonstrated that overproduction of specific antibodies during primary infection induces an enhanced population of cross-reactive antibodies during secondary infection, ultimately leading to severe disease manifestations. In addition, the level of disease severity was found to correlate with immune response kinetics, which was dependent on beginning lymphocyte levels. Our results detail the contribution of specific lymphocytes and antibodies to immunity and memory recall that lead to either protective or pathological outcomes, allowing for the understanding and determination of mechanisms of protective immunity.

scholarly journals Immune defects in patients with pulmonary Mycobacterium abscessus disease without cystic fibrosis

2020 ◽  
Vol 6 (4) ◽  
pp. 00590-2020
Author(s):  
Milou M.F. Schuurbiers ◽  
Mariolina Bruno ◽  
Sanne M.H. Zweijpfenning ◽  
Cecile Magis-Escurra ◽  
Martin Boeree ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Immune Response ◽  
Pulmonary Disease ◽  
Mononuclear Cells ◽  
Interleukin 1 ◽  
Adaptive Immune Response ◽  
Mycobacterium Abscessus ◽  
Adaptive Immune ◽  
Ifn Γ ◽  
Immune Defects

The prevalence of Mycobacterium abscessus infections in non-cystic fibrosis (CF) patients has increased in recent years. In this study, we investigate whether immune defects explain the apparent susceptibility to this opportunistic infection in non-CF patients.We performed stimulations of peripheral blood mononuclear cells and whole blood from 13 patients with M. abscessus pulmonary disease and 13 healthy controls to investigate their cytokine production after 24 h and 7 days.Patients were predominantly women (54%) with a mean age of 59 years; 62% had nodular bronchiectatic disease. Many patients had predisposing pulmonary diseases, such as COPD (46%), and asthma (23%). Patients with COPD showed an impaired interleukin (IL)-6 response to M. abscessus and a reduced IL-17 response to Candida, together with a M. abscessus-specific enhanced IL-22 production. Patients without COPD showed higher levels of interleukin-1 receptor antagonist (IL-1Ra), an anti-inflammatory molecule. Within the non-COPD patients, those with bronchiectasis showed defective interferon (IFN)-γ production in response to Candida albicans.In conclusion, susceptibility to M. abscessus is likely determined by a combination of immunological defects and predisposing pulmonary disease. The main defect in the innate immune response was a shift of the ratio of IL-1β to IL-1Ra, which decreased the bioactivity of this pathway in the adaptive immune response. In the adaptive immune response there was defective IL-17 and IFN-γ production. Patients with COPD and bronchiectasis showed different cytokine defects. It is therefore crucial to interpret the immunological results within the clinical background of the patients tested.

scholarly journals Differential Expression of Immunogenic Proteins on VirulentMycobacterium tuberculosisClinical Isolates

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Pablo Schierloh ◽  
Laura Klepp ◽  
Camila Vazquez ◽  
Roxana Valeria Rocha ◽  
Federico Carlos Blanco ◽  
...  
Keyword(s):  
Immune Response ◽  
Latin American ◽  
Adaptive Immune Response ◽  
Cross Reactivity ◽  
Igg Antibodies ◽  
Humoral Immune ◽  
Adaptive Immune ◽  
Humoral Immune Responses ◽  
Resistant Tuberculosis ◽  
Immunogenic Proteins

Molecular epidemiology has revealed thatMycobacterium tuberculosis(Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated thatMtbfamilies found worldwide today differ in pathology, transmissibility, virulence, and development of immune response. By proteomic approaches seven proteins that were differentially expressed between a local clinical isolate from Latin-American-Mediterranean (LAM) and from Haarlem (H) lineages were identified. In order to analyze the immunogenic ability, recombinant Rv2241, Rv0009, Rv0407, and Rv2624c proteins were produced for testing specific antibody responses. We found that these proteins induced humoral immune responses in patients with drug-sensitive and drug-resistant tuberculosis with substantial cross-reactivity among the four proteins. Moreover, such reactivity was also correlated with anti-Mtb-cell surface IgM, but not with anti-ManLAM, anti-PPD, or anti-Mtb-surface IgG antibodies. Therefore, the present results describe newMtbantigens with potential application as biomarkers of TB.

Double positive CD4+CD8+ T cells are part of the adaptive immune response against Candida albicans

2019 ◽  
Vol 80 (12) ◽  
pp. 999-1005 ◽  
Author(s):  
Barbara Misme-Aucouturier ◽  
Adel Touahri ◽  
Marjorie Albassier ◽  
Francine Jotereau ◽  
Patrice Le Pape ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Candida Albicans ◽  
Cd8 T Cells ◽  
Adaptive Immune Response ◽  
Double Positive ◽  
Adaptive Immune
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