Rare Atg7 Genetic Variants Predispose to Severe Fatty Liver Disease

2021 ◽  
Author(s):  
Guido Baselli ◽  
Serena Pelusi ◽  
Ester Ciociola ◽  
Paola Dongiovanni ◽  
Marco Maggioni ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Severe Fatty Liver

OC-08Rare ATG7 genetic variants predispose to severe fatty liver disease

2021 ◽  
Vol 53 ◽  
pp. S4-S5
Author(s):  
C. Bianco ◽  
F. Malvestiti ◽  
G.A. Baselli ◽  
O. Jamialahmadi ◽  
S. Pelusi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Severe Fatty Liver

scholarly journals Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease

Hepatology ◽  
2018 ◽  
Vol 67 (5) ◽  
pp. 1710-1725 ◽  
Author(s):  
Graham F. Brady ◽  
Raymond Kwan ◽  
Peter J. Ulintz ◽  
Phirum Nguyen ◽  
Shirin Bassirian ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Nuclear Lamina ◽  
Nonalcoholic Fatty Liver

scholarly journals Pediatric Non-Alcoholic Fatty Liver Disease is Affected by Genetic Variants Involved in Lifespan/Healthspan

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Annalisa Crudele ◽  
Serena Dato ◽  
Oriana Lo Re ◽  
Andrea Maugeri ◽  
Paola Sanna ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Jinsheng Yu ◽  
Sharon Marsh ◽  
Junbo Hu ◽  
Wenke Feng ◽  
Chaodong Wu
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Genetic Variants ◽  
Genetic Background ◽  
Fatty Liver Disease ◽  
Genome Wide Association Studies ◽  
Nonalcoholic Fatty Liver ◽  
Pathogenic Mechanisms

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it comprises a spectrum of hepatic abnormalities from simple hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, and liver cancer. While the pathogenesis of NAFLD remains incompletely understood, a multihit model has been proposed that accommodates causal factors from a variety of sources, including intestinal and adipose proinflammatory stimuli acting on the liver simultaneously. Prior cellular and molecular studies of patient and animal models have characterized several common pathogenic mechanisms of NAFLD, including proinflammation cytokines, lipotoxicity, oxidative stress, and endoplasmic reticulum stress. In recent years, gut microbiota has gained much attention, and dysbiosis is recognized as a crucial factor in NAFLD. Moreover, several genetic variants have been identified through genome-wide association studies, particularly rs738409 (Ile748Met) inPNPLA3and rs58542926 (Glu167Lys) inTM6SF2, which are critical risk alleles of the disease. Although a high-fat diet and inactive lifestyles are typical risk factors for NAFLD, the interplay between diet, gut microbiota, and genetic background is believed to be more important in the development and progression of NAFLD. This review summarizes the common pathogenic mechanisms, the gut microbiota relevant mechanisms, and the major genetic variants leading to NAFLD and its progression.

Genetic variants in the MTHFR are not associated with fatty liver disease

2020 ◽  
Vol 40 (8) ◽  
pp. 1934-1940
Author(s):  
Antonio De Vincentis ◽  
Rosellina Margherita Mancina ◽  
Jussi Pihlajamäki ◽  
Ville Männistö ◽  
Salvatore Petta ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease

Association of genetic variants with non-alcoholic fatty liver disease in an urban Sri Lankan community

2014 ◽  
Vol 35 (2) ◽  
pp. 676-679 ◽  
Author(s):  
Anuradhani Kasturiratne ◽  
Koichi Akiyama ◽  
Madunil A Niriella ◽  
Fumihiko Takeuchi ◽  
Masato Isono ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Sri Lankan ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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