scholarly journals Insights into paediatric non-alcoholic fatty liver disease from genetic variants

2019 ◽  
Vol 39 (3) ◽  
pp. 440-445
Author(s):  
Jiawen Dong ◽  
Yu Ri Im ◽  
Jake P. Mann
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Pediatric Non-Alcoholic Fatty Liver Disease is Affected by Genetic Variants Involved in Lifespan/Healthspan

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Annalisa Crudele ◽  
Serena Dato ◽  
Oriana Lo Re ◽  
Andrea Maugeri ◽  
Paola Sanna ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Association of genetic variants with non-alcoholic fatty liver disease in an urban Sri Lankan community

2014 ◽  
Vol 35 (2) ◽  
pp. 676-679 ◽  
Author(s):  
Anuradhani Kasturiratne ◽  
Koichi Akiyama ◽  
Madunil A Niriella ◽  
Fumihiko Takeuchi ◽  
Masato Isono ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Sri Lankan ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Genetic Variants in PNPLA3 and Risk of Non-Alcoholic Fatty Liver Disease in a Han Chinese Population

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50256 ◽  
Author(s):  
Xian-E Peng ◽  
Yun-Li Wu ◽  
Shao-Wei Lin ◽  
Qing-Qing Lu ◽  
Zhi-Jian Hu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Chinese Population ◽  
Han Chinese ◽  
Alcoholic Fatty Liver ◽  
Han Chinese Population ◽  
Alcoholic Fatty Liver Disease

scholarly journals The incidence of candidate genetic variants of non alcoholic fatty liver disease in Saudi Arabian population

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S150-S151
Author(s):  
F.A. AlSaif ◽  
H.S. AlMadany ◽  
M.A. AlOtaiby ◽  
M.A. AlMayouf ◽  
M. Ahmed
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Genetic Variants ◽  
Fatty Liver Disease ◽  
Saudi Arabian ◽  
Alcoholic Fatty Liver ◽  
Arabian Population ◽  
Alcoholic Fatty Liver Disease

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

Non-Alcoholic Fatty Liver Disease in Overweight Children and its Relationship with Retinol Serum Levels

2008 ◽  
Vol 78 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Suano de Souza ◽  
Silverio Amancio ◽  
Saccardo Sarni ◽  
Sacchi Pitta ◽  
Fernandes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Lipid Profile ◽  
Fatty Liver Disease ◽  
Thiobarbituric Acid ◽  
Serum Levels ◽  
Control Group ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Objectives: To evaluate the frequency of non-alcoholic fatty liver disease, the retinol serum levels, lipid profile, and insulin resistance in overweight/obese children. To relate these biochemical variables with the risk of this disease in the population studied. Methods: The study was cross-sectional and prospective, with 46 overweight/obese school children (28 female, 18 male; mean age 8.6 years). The control group consisted of 45 children, paired by age and gender. Hepatic steatosis, evaluated by ultrasound, was classified as normal, mild, moderate, or severe. Also evaluated were serum retinol levels; thiobarbituric acid reactive substances; lipid profile; and fasting glucose and serum insulin levels, used for the calculation of the Homeostasis Model Assessment. Results: Hepatic ultrasound alterations were found in 56.5% and 48,9% of the overweight/obese and control group children, respectively. Presence of obesity was associated with high levels of triglycerides (OR = 4.6; P = 0.002). In the studied children, the risk of steatosis was related to a trend to a higher percentage of retinol inadequacy (OR = 2.8; p = 0.051); there was no association with thiobarbituric acid reactive substances, lipid profile, or insulin resistance. Conclusions: The high frequency of non-alcoholic fatty liver disease in both groups, evaluated by hepatic ultrasound, in low-socioeconomic level children, independent of nutritional condition and without significant association with insulin resistance, emphasizes that especially in developing countries, other risk factors such as micronutrient deficiencies (e.g. vitamin A) are involved.

Sign in / Sign up

Export Citation Format

Share Document