The Prevalence of Multimorbidity and Associations With Clinical Outcomes Among Middle Aged People in Golestan, Iran: A Longitudinal Cohort Study

2021 ◽  
Author(s):  
Maria Lisa Odland ◽  
Samiha Ismail ◽  
Sadaf G. Sepanlou ◽  
Hossein Poustchi ◽  
Alireza Sadjadi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Longitudinal Cohort Study ◽  
Middle Aged ◽  
Longitudinal Cohort ◽  
Aged People

Risk Factors for Neuropathic Pain in Middle-Aged and Elderly People: A Five-Year Longitudinal Cohort in the Yakumo Study

Pain Medicine ◽  
2020 ◽  
Vol 21 (8) ◽  
pp. 1604-1610 ◽  
Author(s):  
Shiro Imagama ◽  
Kei Ando ◽  
Kazuyoshi Kobayashi ◽  
Hiroaki Nakashima ◽  
Taisuke Seki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuropathic Pain ◽  
Cohort Study ◽  
Elderly People ◽  
Longitudinal Cohort Study ◽  
Middle Aged ◽  
Longitudinal Cohort ◽  
Independent Risk Factors ◽  
Lumbar Kyphosis ◽  
Prospective Longitudinal

Abstract Objective To determine the risk factors for new neuropathic pain (NeP) after five years in healthy middle-aged and elderly volunteers. Design Prospective longitudinal cohort study (Yakumo study). Setting Clinical evaluation in a health checkup. Subjects A total of 366 people (male N = 146, female N = 220, average age = 63.5 years) who did not have NeP in 2013 were examined. Methods NeP was diagnosed based on a painDETECT questionnaire score ≥13. Body mass index (BMI), comorbidity, low back pain (LBP), sciatica, physical ability, grip and back muscle strength, osteoporosis, sarcopenia, frailty, spinal alignment, and quality of life (QOL) with the SF36 in 2013 were compared between NeP(+) and NeP(-) subjects in 2018 using multivariate logistic regression analysis. Results The NeP(+) rate in 2018 was 5.2%, with no significant differences in age and gender. NeP(+) subjects had significantly lower BMI, severe sciatica, poor gait ability, higher rates of osteoporosis and sarcopenia, greater lumbar kyphosis and spinal inclination, and poorer mental health in 2013. Poor gait ability (odds ratio [OR] = 8.05), low BMI (OR = 2.31), lumbar kyphosis (OR = 1.38), low percentage of the young adult mean (OR = 1.15), and low mental QOL (OR = 1.06) were identified as significant and independent risk factors for new NeP after five years. Conclusions This longitudinal cohort study identified five independent risk factors for development of new NeP after five years, with related factors of spinal inclination, sarcopenia, and sciatica. New NeP may be prevented by intervention or treatment of these factors at an early stage in relatively healthy middle-aged and elderly people.

Insomnia symptoms in relation to menopause among middle-aged Chinese women: Findings from a longitudinal cohort study

Maturitas ◽  
2020 ◽  
Vol 141 ◽  
pp. 1-8
Author(s):  
Min Luo ◽  
Jiayi Li ◽  
Ruiyi Tang ◽  
Howard J. Li ◽  
Bing Liu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Chinese Women ◽  
Longitudinal Cohort Study ◽  
Middle Aged ◽  
Longitudinal Cohort ◽  
Insomnia Symptoms

scholarly journals Specific Activities and the Trajectories of Cognitive Decline Among Middle-Aged and Older Adults: A Five-Year Longitudinal Cohort Study

2021 ◽  
Vol 80 (3) ◽  
pp. 1039-1050
Author(s):  
Bingyu Li ◽  
Jiefeng Bi ◽  
Chang Wei ◽  
Feng Sha
Keyword(s):  
Cohort Study ◽  
Cognitive Decline ◽  
Cognitive Functions ◽  
Growth Models ◽  
Age Groups ◽  
Longitudinal Cohort Study ◽  
Middle Aged ◽  
Longitudinal Cohort ◽  
Status Effect ◽  
Specific Activities

Background: How specific activities influence cognitive decline among different age groups, especially the late middle-aged and the early old, remains inadequately studied. Objective: To examine the association between specific activities with trajectories of cognitive functions in different age groups in China. Methods: A longitudinal cohort study was conducted based on data from the China Health and Retirement Longitudinal Study (CHARLS). Mixed effects growth models were applied to analyze the association between specific activities and cognitive functions. Results: Interacting with friends (infrequent: β= 0.13, confidence interval [CI] = 0.03 to 0.22; daily: β= 0.19, CI = 0.09 to 0.28), playing Mah-jong or other games (infrequent: β= 0.12, CI = 0.02 to 0.22; daily:β= 0.26, CI = 0.10 to 0.42), infrequent providing help to others (β= 0.24, CI = 0.11 to 0.37), and going to a sport (infrequent: β= 0.31, CI = 0.08 to 0.54); daily: β= 0.22, CI = 0.05 to 0.38) are significantly associated with participants’ memory. Infrequently playing Mah-jong or other games (β= 0.30, CI = 0.17 to 0.43) and daily sports (β= 0.24, CI = 0.03 to 0.45) are significantly associated with better mental status. Effect of each activity varies among population of different age, education level, gender, and residence. Conclusion: This study identifies four social activities that are associated with better cognitive functions, and provides a comprehensive, in-depth understanding on the specific protective effect of each activity among different subgroups.

Burden and clinical outcomes of hospital-coded infections in patients with cancer: an 11-year longitudinal cohort study at an Australian cancer centre

2020 ◽  
Vol 28 (12) ◽  
pp. 6023-6034
Author(s):  
Jake C. Valentine ◽  
Lisa Hall ◽  
Tim Spelman ◽  
Karin M. Verspoor ◽  
John F. Seymour ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Cancer Centre ◽  
Patients With Cancer

scholarly journals A Retrospective Longitudinal Cohort Study of The Clinical Burden in Myasthenia Gravis

2021 ◽  
Author(s):  
Linda Harris ◽  
Sophie Graham ◽  
Sharon MacLachlan ◽  
Alex Exuzides ◽  
Saiju Jacob
Keyword(s):  
Cohort Study ◽  
Myasthenia Gravis ◽  
Clinical Outcomes ◽  
Conventional Treatment ◽  
Longitudinal Cohort Study ◽  
Distributed Data ◽  
Longitudinal Cohort ◽  
All Cause Mortality ◽  
Treatment Refractory

Abstract Background Patients with generalized myasthenia gravis (MG) often experience debilitating exacerbations, with the possibility of life-threatening respiratory crises requiring hospitalization. Long-term longitudinal studies are needed to understand the burden of MG, including in patients whose disease is refractory to conventional treatment. Methods A retrospective, longitudinal, cohort study was conducted of patients in England aged ≥18 years with treatment-refractory or non-refractory MG, using data recorded during 1997–2016 in the Clinical Practice Research Datalink and the Hospital Episode Statistics databases. A control cohort of patients without MG, matched to the patients in the treatment-refractory MG cohort, was also identified. Outcome measures included myasthenic crises, MG exacerbations, MG-related hospitalizations, comorbidities, and all-cause mortality. Descriptive statistics were calculated for the overall MG population. For continuous variables, between-cohort comparisons were made using t tests for normally distributed data and Mann–Whitney U tests for non-normally distributed data. For categorical data, the comparisons were made by chi-squared tests. Differences in clinical outcomes between cohorts were modeled using negative binomial regression. Results A total of 1149 patients with MG were included. Overall, 18.4% of patients experienced myasthenic crises, 24.6% experienced exacerbations, and 38.6% underwent MG-related hospitalizations. Most of these events occurred within 2–3 years of diagnosis. Patients with MG refractory to conventional treatment (n=66) experienced more exacerbations and MG-related hospitalizations than patients with non-refractory disease (n=1083). Patients with refractory MG experienced a higher frequency of renal disease and hypertension compared with patients with non-refractory MG, and with matched patients without MG. They were also more likely to have diabetes and congestive heart failure than the matched controls. Rates of all-cause mortality during the follow-up period did not differ between patients with refractory MG and non-refractory MG. Conclusions These results show that conventional treatments for MG are not adequately managing patients’ symptoms and that patients with refractory MG are more likely to experience certain comorbidities than those with non-refractory MG or matched controls without MG. Future research should focus on the impact of newer targeted therapies on long-term clinical outcomes and comorbid conditions.

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