scholarly journals Adverse clinical outcomes among youths with nonsuicidal self‐injury and suicide attempts: a longitudinal cohort study

2021 ◽  
Author(s):  
Johan Bjureberg ◽  
Ralf Kuja‐Halkola ◽  
Anna Ohlis ◽  
Paul Lichtenstein ◽  
Brian M. D’Onofrio ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Suicide Attempts ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Self Injury ◽  
Nonsuicidal Self Injury

Burden and clinical outcomes of hospital-coded infections in patients with cancer: an 11-year longitudinal cohort study at an Australian cancer centre

2020 ◽  
Vol 28 (12) ◽  
pp. 6023-6034
Author(s):  
Jake C. Valentine ◽  
Lisa Hall ◽  
Tim Spelman ◽  
Karin M. Verspoor ◽  
John F. Seymour ◽  
...  
Keyword(s):  
Cohort Study ◽  
Clinical Outcomes ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort ◽  
Cancer Centre ◽  
Patients With Cancer

scholarly journals A Retrospective Longitudinal Cohort Study of The Clinical Burden in Myasthenia Gravis

2021 ◽  
Author(s):  
Linda Harris ◽  
Sophie Graham ◽  
Sharon MacLachlan ◽  
Alex Exuzides ◽  
Saiju Jacob
Keyword(s):  
Cohort Study ◽  
Myasthenia Gravis ◽  
Clinical Outcomes ◽  
Conventional Treatment ◽  
Longitudinal Cohort Study ◽  
Distributed Data ◽  
Longitudinal Cohort ◽  
All Cause Mortality ◽  
Treatment Refractory

Abstract Background Patients with generalized myasthenia gravis (MG) often experience debilitating exacerbations, with the possibility of life-threatening respiratory crises requiring hospitalization. Long-term longitudinal studies are needed to understand the burden of MG, including in patients whose disease is refractory to conventional treatment. Methods A retrospective, longitudinal, cohort study was conducted of patients in England aged ≥18 years with treatment-refractory or non-refractory MG, using data recorded during 1997–2016 in the Clinical Practice Research Datalink and the Hospital Episode Statistics databases. A control cohort of patients without MG, matched to the patients in the treatment-refractory MG cohort, was also identified. Outcome measures included myasthenic crises, MG exacerbations, MG-related hospitalizations, comorbidities, and all-cause mortality. Descriptive statistics were calculated for the overall MG population. For continuous variables, between-cohort comparisons were made using t tests for normally distributed data and Mann–Whitney U tests for non-normally distributed data. For categorical data, the comparisons were made by chi-squared tests. Differences in clinical outcomes between cohorts were modeled using negative binomial regression. Results A total of 1149 patients with MG were included. Overall, 18.4% of patients experienced myasthenic crises, 24.6% experienced exacerbations, and 38.6% underwent MG-related hospitalizations. Most of these events occurred within 2–3 years of diagnosis. Patients with MG refractory to conventional treatment (n=66) experienced more exacerbations and MG-related hospitalizations than patients with non-refractory disease (n=1083). Patients with refractory MG experienced a higher frequency of renal disease and hypertension compared with patients with non-refractory MG, and with matched patients without MG. They were also more likely to have diabetes and congestive heart failure than the matched controls. Rates of all-cause mortality during the follow-up period did not differ between patients with refractory MG and non-refractory MG. Conclusions These results show that conventional treatments for MG are not adequately managing patients’ symptoms and that patients with refractory MG are more likely to experience certain comorbidities than those with non-refractory MG or matched controls without MG. Future research should focus on the impact of newer targeted therapies on long-term clinical outcomes and comorbid conditions.

2453-PUB: Changes in Metabolic Syndrome and Diabetes Risk: A Nationwide Longitudinal Cohort Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2453-PUB
Author(s):  
MIN-KYUNG LEE ◽  
HYUK-SANG KWON ◽  
KI-HO SONG ◽  
JAE HYUK LEE
Keyword(s):  
Metabolic Syndrome ◽  
Cohort Study ◽  
Diabetes Risk ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort
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