Early Prediction of Preeclampsia by Using Serum Human Leukocyte Antigen G: A Retrospective Case-Control Study Followed by a Prospective Unselected Cohort Study

2020 ◽  
Author(s):  
Jian-bo Zhang ◽  
Wei She ◽  
Jun Yue ◽  
Yi Huang ◽  
Zhi-ying Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Early Prediction ◽  
Retrospective Case ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
Control Study ◽  
Unselected Cohort

scholarly journals High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
David Cantú de León ◽  
Delia Pérez-Montiel ◽  
Verónica Villavicencio ◽  
Alejandro García Carranca ◽  
Alejandro Mohar Betancourt ◽  
...  
Keyword(s):  
Sporadic Breast Cancer ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Breast Cancer Case ◽  
Hla Class I ◽  
Case Control ◽  
Cancer Case ◽  
Mexican Mestizo ◽  
Leukocyte Antigen ◽  
Control Study

scholarly journals Uterine Natural Killer Cell and Human Leukocyte Antigen-G1 and Human Leukocyte Antigen-G5 Expression in Vaginal Discharge of Threatened-Abortion Women: A Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Saeideh Sadat Shobeiri ◽  
Zahra Rahmani ◽  
Hadi Hossein Nataj ◽  
Hossein Ranjbaran ◽  
Masoud Mohammadi ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Pregnant Women ◽  
Vaginal Discharge ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Leukocyte Antigen ◽  
Unk Cells ◽  
Threatened Abortion ◽  
Control Study

The immunotolerant human leukocyte antigen-G (HLA-G) molecules have a major role in fetal-maternal tolerance during pregnancy. Interaction between these molecules and uterine natural killer (uNK) cells inhibitory receptors prevents NK cell invasion against fetus trophoblast cells. The aim of this study was to evaluate the percentages of uNK cells and HLA-G1 and HLA-G5 isoforms expression in vaginal discharge of threatened-abortion women in comparison with control. In a case-control study, we investigated 30 threatened-abortion women with bleeding or spotting less than 20 weeks of pregnancy as compared to 30 normal pregnant women. uNK cells percentage was assessed by flow cytometry. Furthermore, we evaluated HLA-G1 and HLA-G5 isoforms expression by Real-Time PCR in these groups. The results of this study showed that threatened-abortion women had increased uNK cells and decreased T cells percentage in vaginal discharge in comparison with normal pregnant women (p=0.01,p=0.003, resp.). In addition, HLA-G1 isoform had lower expression in threatened-abortion women in comparison with control groupp=0.0001. The increase of uNK cells level with the decrease of HLA-G expression in vaginal discharge of threatened-abortion pregnant women is an indicator of mother’s immune dysregulation. It is concluded that HLA-G expression level with uNK cells percentage can be determined as a diagnostic marker for threatened-abortion women.

scholarly journals Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study

2020 ◽  
Vol 20 ◽  
Author(s):  
Regina Purnama Dewi Iskandar ◽  
Alida ◽  
Ari Triwardhani ◽  
Ida Bagus Narmada ◽  
Faizah Hanum ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Orofacial Cleft ◽  
Leukocyte Antigen ◽  
Control Study
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