scholarly journals Anti-citrullinated peptide autoantibodies, human leukocyte antigen shared epitope and risk of future rheumatoid arthritis: a nested case–control study

2013 ◽  
Vol 15 (5) ◽  
pp. R159 ◽  
Author(s):  
Elizabeth V Arkema ◽  
Barbara L Goldstein ◽  
William Robinson ◽  
Jeremy Sokolove ◽  
Catriona A Wagner ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Human Leukocyte Antigen ◽  
Case Control Study ◽  
Shared Epitope ◽  
Human Leukocyte ◽  
Case Control ◽  
Leukocyte Antigen ◽  
Nested Case Control ◽  
Citrullinated Peptide ◽  
Control Study

scholarly journals Uterine Natural Killer Cell and Human Leukocyte Antigen-G1 and Human Leukocyte Antigen-G5 Expression in Vaginal Discharge of Threatened-Abortion Women: A Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Saeideh Sadat Shobeiri ◽  
Zahra Rahmani ◽  
Hadi Hossein Nataj ◽  
Hossein Ranjbaran ◽  
Masoud Mohammadi ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Pregnant Women ◽  
Vaginal Discharge ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Leukocyte Antigen ◽  
Unk Cells ◽  
Threatened Abortion ◽  
Control Study

The immunotolerant human leukocyte antigen-G (HLA-G) molecules have a major role in fetal-maternal tolerance during pregnancy. Interaction between these molecules and uterine natural killer (uNK) cells inhibitory receptors prevents NK cell invasion against fetus trophoblast cells. The aim of this study was to evaluate the percentages of uNK cells and HLA-G1 and HLA-G5 isoforms expression in vaginal discharge of threatened-abortion women in comparison with control. In a case-control study, we investigated 30 threatened-abortion women with bleeding or spotting less than 20 weeks of pregnancy as compared to 30 normal pregnant women. uNK cells percentage was assessed by flow cytometry. Furthermore, we evaluated HLA-G1 and HLA-G5 isoforms expression by Real-Time PCR in these groups. The results of this study showed that threatened-abortion women had increased uNK cells and decreased T cells percentage in vaginal discharge in comparison with normal pregnant women (p=0.01,p=0.003, resp.). In addition, HLA-G1 isoform had lower expression in threatened-abortion women in comparison with control groupp=0.0001. The increase of uNK cells level with the decrease of HLA-G expression in vaginal discharge of threatened-abortion pregnant women is an indicator of mother’s immune dysregulation. It is concluded that HLA-G expression level with uNK cells percentage can be determined as a diagnostic marker for threatened-abortion women.

scholarly journals Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study

2020 ◽  
Vol 20 ◽  
Author(s):  
Regina Purnama Dewi Iskandar ◽  
Alida ◽  
Ari Triwardhani ◽  
Ida Bagus Narmada ◽  
Faizah Hanum ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Orofacial Cleft ◽  
Leukocyte Antigen ◽  
Control Study

scholarly journals Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

PLoS Medicine ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. e1002272 ◽  
Author(s):  
Natasha Z. R. Steele ◽  
Jessie S. Carr ◽  
Luke W. Bonham ◽  
Ethan G. Geier ◽  
Vincent Damotte ◽  
...  
Keyword(s):  
Risk Factor ◽  
Alzheimer Disease ◽  
Human Leukocyte Antigen ◽  
Fine Mapping ◽  
Case Control Study ◽  
Human Leukocyte ◽  
Case Control ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen Locus ◽  
Control Study
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