BET Inhibition Induces Vulnerability to MCL1 Targeting Through Upregulation of Fatty Acid Synthesis Pathway in Breast Cancer

2020 ◽  
Author(s):  
Gonghong Yan ◽  
Augustin Luna ◽  
Heping Wang ◽  
Behnaz Bozorgui ◽  
Xubin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway

scholarly journals Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

2009 ◽  
Vol 118 (3) ◽  
pp. 565-574 ◽  
Author(s):  
Daniele Campa ◽  
James McKay ◽  
Olga Sinilnikova ◽  
Anika Hüsing ◽  
Ulla Vogel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variation ◽  
Fatty Acid ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway

scholarly journals Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene

2018 ◽  
Vol 62 (9) ◽  
Author(s):  
Christopher E. Wozniak ◽  
Zhenjian Lin ◽  
Eric W. Schmidt ◽  
Kelly T. Hughes ◽  
Theodore G. Liou
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Target Gene ◽  
Gene Clusters ◽  
Acid Synthesis ◽  
Inducible Promoter ◽  
Content Type ◽  
Uncharacterized Gene ◽  
Fatty Acid Synthesis Pathway ◽  
Genetic Techniques

ABSTRACTMicrobes encode many uncharacterized gene clusters that may produce antibiotics and other bioactive small molecules. Methods for activating these genes are needed to explore their biosynthetic potential. A transposon containing an inducible promoter was randomly inserted into the genome of the soil bacteriumBurkholderia thailandensisto induce antibiotic expression. This screen identified the polyketide/nonribosomal peptide thailandamide as an antibiotic and discovered its regulator, AtsR. Mutants ofSalmonellaresistant to thailandamide had mutations in theaccAgene for acetyl coenzyme A (acetyl-CoA) carboxylase, which is one of the first enzymes in the fatty acid synthesis pathway. A second copy ofaccAin the thailandamide synthesis gene cluster keepsB. thailandensisresistant to its own antibiotic. These genetic techniques will likely be powerful tools for discovering other unusual antibiotics.

TAMI-05. FATTY ACID SYNTHESIS IS REQUIRED FOR HER2+ BREAST CANCER BRAIN METASTASIS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi199-vi199
Author(s):  
Gino Ferraro ◽  
Ahmed Ali ◽  
Alba Luengo ◽  
Amy Deik ◽  
Keene Abbott ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Fatty Acid ◽  
Growth Factor ◽  
Fatty Acid Synthesis ◽  
Growth Factor Receptor ◽  
Breast Tumors ◽  
Acid Synthesis ◽  
Epidermal Growth ◽  
The Brain

Abstract Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.

Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours

MedChemComm ◽  
2013 ◽  
Vol 4 (10) ◽  
pp. 1350 ◽  
Author(s):  
Federica Pisaneschi ◽  
Timothy H. Witney ◽  
Lisa Iddon ◽  
Eric O. Aboagye
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Pet Imaging ◽  
Acid Synthesis ◽  
Pivalic Acid ◽  
Imaging Probe ◽  
Fatty Acid Synthesis Pathway

scholarly journals Fatty acid synthesis pathway provides lipid precursors for rhamnolipid biosynthesis in Burkholderia thailandensis E264

2018 ◽  
Vol 102 (14) ◽  
pp. 6163-6174 ◽  
Author(s):  
Victor U. Irorere ◽  
Thomas J. Smyth ◽  
Diego Cobice ◽  
Stephen McClean ◽  
Roger Marchant ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Burkholderia Thailandensis ◽  
Fatty Acid Synthesis Pathway

Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co‐repressor acyl‐ACP

FEBS Letters ◽  
2019 ◽  
Vol 593 (19) ◽  
pp. 2730-2741 ◽  
Author(s):  
Gang Zuo ◽  
Zhi‐Peng Chen ◽  
Yong‐Liang Jiang ◽  
Zhongliang Zhu ◽  
Chengtao Ding ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway ◽  
Structural Insights
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