Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours

MedChemComm ◽  
2013 ◽  
Vol 4 (10) ◽  
pp. 1350 ◽  
Author(s):  
Federica Pisaneschi ◽  
Timothy H. Witney ◽  
Lisa Iddon ◽  
Eric O. Aboagye
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Pet Imaging ◽  
Acid Synthesis ◽  
Pivalic Acid ◽  
Imaging Probe ◽  
Fatty Acid Synthesis Pathway

Propionic Acid-Based PET Imaging of the Fatty Acid Synthesis Pathway in Prostate Cancer

2020 ◽  
Author(s):  
Ganghua Tang ◽  
Shaoyu Liu ◽  
Ping Hu ◽  
Hui Ma ◽  
Xianhong Xiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Pet Imaging ◽  
Broad Spectrum ◽  
Fatty Acid Synthase ◽  
Acid Synthesis ◽  
Potential Value ◽  
Fatty Acid Synthesis Pathway

Abstract BackgroundThe aim of this study was to evaluate the potential value of 2-[18F]fluoropropionic acid ([18F]FPA) for PET imaging of prostate cancer (PCa) and to confirm the correlation between [18F]FPA accumulation and fatty acid synthase (FASN) levels in PCa models. The results of the first [18F]FPA PET study of a PCa patient are reported.MethodsA PET imaging comparison of [18F]FDG and [18F]FPA was performed in LNCaP, PC-3 and DU145 tumors. Additionally, in vivo blocking experiments in those models were conducted with orlistat. Western blotting staining of FASN were performed in the those xenograft tumors.ResultsThe uptake of [18F]FPA in the LNCaP and PC-3 tumors was higher than that of [18F]FDG (P<0.05 and P<0.05), while [18F]FDG was significantly superior to [18F]FPA in detecting DU145 tumors (P<0.05). Grayscale scanning showed that FASN expression in the LNCaP and PC-3 tumors was 33.3% and 10.3% higher than that in the DU145 tumors, respectively. The accumulation (% ID/g) of [18F]FPA in the LNCaP , PC-3 and DU145 tumors decreased by 27.6, 40.5 and 11.7%, respectively, after treatment with orlistat. The [18F]FPA showed higher tumor/background ratios than [18F]FDG in the first PCa patient (P<0.05).ConclusionsThe [18F]FPA uptake in PCa models was positively correlated with FASN expression and could be reduced after administration of a single FASN inhibitor. In addition, the [18F]FPA is a potential broad-spectrum PET imaging agent, and the imaging effect of [18F]FPA may be superior to [18F]FDG in human PCa.

scholarly journals Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene

2018 ◽  
Vol 62 (9) ◽  
Author(s):  
Christopher E. Wozniak ◽  
Zhenjian Lin ◽  
Eric W. Schmidt ◽  
Kelly T. Hughes ◽  
Theodore G. Liou
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Target Gene ◽  
Gene Clusters ◽  
Acid Synthesis ◽  
Inducible Promoter ◽  
Content Type ◽  
Uncharacterized Gene ◽  
Fatty Acid Synthesis Pathway ◽  
Genetic Techniques

ABSTRACTMicrobes encode many uncharacterized gene clusters that may produce antibiotics and other bioactive small molecules. Methods for activating these genes are needed to explore their biosynthetic potential. A transposon containing an inducible promoter was randomly inserted into the genome of the soil bacteriumBurkholderia thailandensisto induce antibiotic expression. This screen identified the polyketide/nonribosomal peptide thailandamide as an antibiotic and discovered its regulator, AtsR. Mutants ofSalmonellaresistant to thailandamide had mutations in theaccAgene for acetyl coenzyme A (acetyl-CoA) carboxylase, which is one of the first enzymes in the fatty acid synthesis pathway. A second copy ofaccAin the thailandamide synthesis gene cluster keepsB. thailandensisresistant to its own antibiotic. These genetic techniques will likely be powerful tools for discovering other unusual antibiotics.

scholarly journals Fatty acid synthesis pathway provides lipid precursors for rhamnolipid biosynthesis in Burkholderia thailandensis E264

2018 ◽  
Vol 102 (14) ◽  
pp. 6163-6174 ◽  
Author(s):  
Victor U. Irorere ◽  
Thomas J. Smyth ◽  
Diego Cobice ◽  
Stephen McClean ◽  
Roger Marchant ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Burkholderia Thailandensis ◽  
Fatty Acid Synthesis Pathway

Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co‐repressor acyl‐ACP

FEBS Letters ◽  
2019 ◽  
Vol 593 (19) ◽  
pp. 2730-2741 ◽  
Author(s):  
Gang Zuo ◽  
Zhi‐Peng Chen ◽  
Yong‐Liang Jiang ◽  
Zhongliang Zhu ◽  
Chengtao Ding ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway ◽  
Structural Insights

scholarly journals Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

2009 ◽  
Vol 118 (3) ◽  
pp. 565-574 ◽  
Author(s):  
Daniele Campa ◽  
James McKay ◽  
Olga Sinilnikova ◽  
Anika Hüsing ◽  
Ulla Vogel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Variation ◽  
Fatty Acid ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway
Sign in / Sign up

Export Citation Format

Share Document