Prefrontal Synaptic Activation During Hippocampal Memory Reactivation

2020 ◽  
Author(s):  
Yuya Nishimura ◽  
Yuji Ikegaya ◽  
Takuya Sasaki
Keyword(s):  
Synaptic Activation ◽  
Memory Reactivation

scholarly journals Prefrontal synaptic activation during hippocampal memory reactivation

Cell Reports ◽  
2021 ◽  
Vol 34 (12) ◽  
pp. 108885
Author(s):  
Yuya Nishimura ◽  
Yuji Ikegaya ◽  
Takuya Sasaki
Keyword(s):  
Synaptic Activation ◽  
Memory Reactivation

scholarly journals Endogenous memory reactivation during sleep in humans is clocked by slow oscillation-spindle complexes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Thomas Schreiner ◽  
Marit Petzka ◽  
Tobias Staudigl ◽  
Bernhard P. Staresina
Keyword(s):  
Memory Function ◽  
Nrem Sleep ◽  
Stimulus Category ◽  
Learning Material ◽  
Memory Reactivation ◽  
Eeg Recordings ◽  
Surface Eeg ◽  
Function Of Sleep ◽  
Prior Experiences

AbstractSleep is thought to support memory consolidation via reactivation of prior experiences, with particular electrophysiological sleep signatures (slow oscillations (SOs) and sleep spindles) gating the information flow between relevant brain areas. However, empirical evidence for a role of endogenous memory reactivation (i.e., without experimentally delivered memory cues) for consolidation in humans is lacking. Here, we devised a paradigm in which participants acquired associative memories before taking a nap. Multivariate decoding was then used to capture endogenous memory reactivation during non-rapid eye movement (NREM) sleep in surface EEG recordings. Our results reveal reactivation of learning material during SO-spindle complexes, with the precision of SO-spindle coupling predicting reactivation strength. Critically, reactivation strength (i.e. classifier evidence in favor of the previously studied stimulus category) in turn predicts the level of consolidation across participants. These results elucidate the memory function of sleep in humans and emphasize the importance of SOs and spindles in clocking endogenous consolidation processes.

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Nature ◽  
1993 ◽  
Vol 363 (6427) ◽  
pp. 347-350 ◽  
Author(s):  
Zafar I. Bashir ◽  
Zuner A. Bortolotto ◽  
Ceri H. Davies ◽  
Nicola Berretta ◽  
Andrew J. Irving ◽  
...  
Keyword(s):  
Synaptic Activation ◽  
Metabotropic Receptors

scholarly journals Targeted memory reactivation in REM but not SWS selectively reduces arousal responses

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Isabel C. Hutchison ◽  
Stefania Pezzoli ◽  
Maria-Efstratia Tsimpanouli ◽  
Mahmoud E. A. Abdellahi ◽  
Penelope A. Lewis
Keyword(s):  
Slow Wave Sleep ◽  
Sleep Stage ◽  
Emotional Memory ◽  
Rapid Eye Movement Sleep ◽  
Emotional Experiences ◽  
Memory Reactivation ◽  
Emotional Memories ◽  
The Impact ◽  
Subjective Arousal ◽  
Spontaneous Reactivation

AbstractA growing body of evidence suggests that sleep can help to decouple the memory of emotional experiences from their associated affective charge. This process is thought to rely on the spontaneous reactivation of emotional memories during sleep, though it is still unclear which sleep stage is optimal for such reactivation. We examined this question by explicitly manipulating memory reactivation in both rapid-eye movement sleep (REM) and slow-wave sleep (SWS) using targeted memory reactivation (TMR) and testing the impact of this manipulation on habituation of subjective arousal responses across a night. Our results show that TMR during REM, but not SWS significantly decreased subjective arousal, and this effect is driven by the more negative stimuli. These results support one aspect of the sleep to forget, sleep to remember (SFSR) hypothesis which proposes that emotional memory reactivation during REM sleep underlies sleep-dependent habituation.

scholarly journals Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

2015 ◽  
Vol 77 ◽  
pp. 173-190 ◽  
Author(s):  
R.L. Nosheny ◽  
P.V. Belichenko ◽  
B.L. Busse ◽  
A.M. Weissmiller ◽  
V. Dang ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Synaptic Activation ◽  
Downstream Signaling

scholarly journals Emotional arousal modulates oscillatory correlates of targeted memory reactivation during NREM, but not REM sleep

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mick Lehmann ◽  
Thomas Schreiner ◽  
Erich Seifritz ◽  
Björn Rasch
Keyword(s):  
Rem Sleep ◽  
Emotional Arousal ◽  
Memory Reactivation

Developmental differences in memory reactivation relate to encoding and inference in the human brain

2021 ◽  
Author(s):  
Margaret L. Schlichting ◽  
Katharine F. Guarino ◽  
Hannah E. Roome ◽  
Alison R. Preston
Keyword(s):  
Human Brain ◽  
Developmental Differences ◽  
Memory Reactivation

scholarly journals 0098 The Effects of Targeted Memory Reactivation During a Daytime Nap on Sensorimotor Skill Performance in Healthy Young Adults

SLEEP ◽  
2018 ◽  
Vol 41 (suppl_1) ◽  
pp. A39-A40
Author(s):  
B P Johnson ◽  
S M Scharf ◽  
A C Verceles ◽  
K P Westlake
Keyword(s):  
Young Adults ◽  
Memory Reactivation ◽  
Skill Performance ◽  
Daytime Nap

scholarly journals Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex

Neuron ◽  
2017 ◽  
Vol 95 (6) ◽  
pp. 1406-1419.e5 ◽  
Author(s):  
Aaron A. Wilber ◽  
Ivan Skelin ◽  
Wei Wu ◽  
Bruce L. McNaughton
Keyword(s):  
Parietal Cortex ◽  
Laminar Organization ◽  
Memory Reactivation
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