Rat Calvarial Bone Regeneration by 3D-Printed Beta-Tricalcium Phosphate Incorporating MicroRNA-200c

2020 ◽  
Author(s):  
Matthew T. Remy ◽  
Adil Akkouch ◽  
Li He ◽  
Steven Eliason ◽  
Mason E. Sweat ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Bone ◽  
Beta Tricalcium Phosphate ◽  
3D Printed

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

scholarly journals Rat Calvarial Bone Regeneration by 3D-Printed β-Tricalcium Phosphate Incorporating MicroRNA-200c

2021 ◽  
Vol 7 (9) ◽  
pp. 4521-4534
Author(s):  
Matthew T. Remy ◽  
Adil Akkouch ◽  
Li He ◽  
Steven Eliason ◽  
Mason E. Sweat ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Bone ◽  
3D Printed

3D printed polycaprolactone/beta-tricalcium phosphate/magnesium peroxide oxygen releasing scaffold enhances osteogenesis and implanted BMSCs survival in repairing the large bone defect

2021 ◽  
Author(s):  
Ziyue Peng ◽  
Chengqiang Wang ◽  
Chun Liu ◽  
Haixia Xu ◽  
Yihan Wang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Large Bone Defect ◽  
Beta Tricalcium Phosphate ◽  
Defect Area ◽  
3D Printed ◽  
Magnesium Peroxide ◽  
Large Bone ◽  
Phosphate Magnesium

Fabricate a MgO2-contained scaffold by 3D printing to improve ischemia and hypoxia in bone defect area.

scholarly journals Bone Healing Improvements Using Hyaluronic Acid and Hydroxyapatite/Beta-Tricalcium Phosphate in Combination: An Animal Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Yen-Lan Chang ◽  
Yi-June Lo ◽  
Sheng-Wei Feng ◽  
Yu-Chih Huang ◽  
Hsin-Yuan Tsai ◽  
...  
Keyword(s):  
Bone Healing ◽  
Tricalcium Phosphate ◽  
Control Sample ◽  
Volume Density ◽  
Parietal Bone ◽  
Control Group ◽  
Calvarial Bone ◽  
Handling Characteristics ◽  
Beta Tricalcium Phosphate ◽  
Aqueous Binder

The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.

Effects of porous beta-tricalcium phosphate-based ceramics used as an E. coli-derived rhBMP-2 carrier for bone regeneration

2013 ◽  
Vol 24 (9) ◽  
pp. 2117-2127 ◽  
Author(s):  
Jae Hyup Lee ◽  
Mi Young Ryu ◽  
Hae-Ri Baek ◽  
Kyung Mee Lee ◽  
Jun-Hyuk Seo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
E Coli ◽  
Beta Tricalcium Phosphate

scholarly journals Histological Evaluation of a New Beta-Tricalcium Phosphate/Hydroxyapatite/Poly (1-Lactide-Co-Caprolactone) Composite Biomaterial in the Inflammatory Process and Repair of Critical Bone Defects

Symmetry ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1356
Author(s):  
Elizabeth Ferreira Martinez ◽  
Ana Elisa Amaro Rodrigues ◽  
Lucas Novaes Teixeira ◽  
Andrea Rodrigues Esposito ◽  
Walter Israel Rojas Cabrera ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Inflammatory Process ◽  
Histological Evaluation ◽  
Alloplastic Material ◽  
Beta Tricalcium Phosphate ◽  
Evaluation Time ◽  
Synthetic Biomaterial ◽  
Critical Bone Defects

Background: The use of biomaterials is commonplace in dentistry for bone regeneration. The aim of this study was to evaluate the performance of a new alloplastic material for bone repair in critical defects and to evaluate the extent of the inflammatory process. Methods: Forty-five New Zealand rabbits were divided into five groups according to evaluation time (7, 14, 30, 60, 120 days), totaling 180 sites with six-millimeter diameter defects in their tibiae. The defects were filled with alloplastic material consisting of poly (lactide-co-caprolactone), beta-tricalcium phosphate, hydroxyapatite and nano-hydroxyapatite (BTPHP) in three different presentations: paste, block, and membrane. Comparisons were established with reference materials, such as Bio-ossTM, Bio-oss CollagenTM, and Bio-gideTM, respectively. The samples were HE-stained and evaluated for inflammatory infiltrate (scored for intensity from 0 to 3) and the presence of newly formed bone at the periphery of the defects. Results: Greater bone formation was observed for the alloplastic material and equivalent inflammatory intensity for both materials, regardless of evaluation time. At 30 days, part of the synthetic biomaterial, regardless of the presentation, was resorbed. Conclusions: We concluded that this novel alloplastic material showed osteoconductive potential, biocompatibility, low inflammatory response, and gradual resorption, thus an alternative strategy for guided bone regeneration.

scholarly journals Bone regeneration of calvarial defect using marine calcareous-derived beta-tricalcium phosphate macrospheres

2014 ◽  
Vol 5 ◽  
pp. 204173141452344 ◽  
Author(s):  
Joshua Chou ◽  
Jia Hao ◽  
Shinji Kuroda ◽  
Besim Ben-Nissan ◽  
Bruce Milthopre ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Beta Tricalcium Phosphate

Foamed β-Tricalcium Phosphate Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 323-326 ◽  
Author(s):  
Edgar Benjamin Montufar ◽  
C. Gil ◽  
Tania Traykova ◽  
M.P. Ginebra ◽  
Josep A. Planell
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Initial Material ◽  
Sintering Process ◽  
Bioactive Material ◽  
Bioactive Scaffolds ◽  
Calcium Phosphate Cements ◽  
Beta Tricalcium Phosphate ◽  
Nanometric Range

The design and processing of 3D macroporous bioactive scaffolds is one of the milestones for the progress of bone tissue engineering and bone regeneration. Calcium phosphate based ceramics are among the most suitable materials, due to their similarity to the bone mineral. Specifically, beta-tricalcium phosphate (β-TCP) is known to be a resorbable and bioactive material, with well established applications as bone regeneration material. The aim of this work is to explore a new route to obtain β-TCP macroporous scaffolds starting from calcium phosphate cements. To this end foamed calcium phosphate cement, composed of alpha tricalcium phosphate as starting powder was used as initial material. The set foamed structures, made of calcium deficient hydroxyapatite (CDHA) were sintered to obtain the final β-TCP macroporous architecture. The interconnected macroporosity was maintained, whereas the porosity in the nanometric range was strongly reduced by the sintering process. The sintering produced also an increase in the mechanical properties of the scaffold.

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