Optimal Strategies to Screen Health Care Workers for COVID-19 in the US with SARS-CoV-2 PCR and IgG Antibody Assays

2020 ◽  
Author(s):  
Sigal Maya ◽  
Guntas Padda ◽  
Victoria Close ◽  
Trevor Wilson ◽  
Fareeda Ahmed ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Optimal Strategies ◽  
Igg Antibody ◽  
Care Workers ◽  
The Us ◽  
Antibody Assays

Food Insecurity Among Health Care Workers In The US

2021 ◽  
Vol 40 (9) ◽  
pp. 1449-1456
Author(s):  
Mithuna Srinivasan ◽  
Xi Cen ◽  
Brandy Farrar ◽  
Jennifer A. Pooler ◽  
Talia Fish
Keyword(s):  
Health Care ◽  
Food Insecurity ◽  
Health Care Workers ◽  
Care Workers ◽  
The Us

scholarly journals Caveats in interpreting SARS‐CoV‐2 IgM + /IgG − antibody profile in asymptomatic health care workers

2020 ◽  
Vol 93 (2) ◽  
pp. 634-636 ◽  
Author(s):  
Arantxa Valdivia ◽  
Ignacio Torres ◽  
Dixie Huntley ◽  
María Jesús Alcaraz ◽  
Eliseo Albert ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Igg Antibody ◽  
Care Workers ◽  
Antibody Profile

scholarly journals Neutralizing antibodies to SARS-CoV-2 Omicron variant after 3rd mRNA vaccination in health care workers and elderly subjects and response to a single dose in previously infected adults

2021 ◽  
Author(s):  
Anu Haveri ◽  
Anna Solastie ◽  
Nina Ekström ◽  
Pamela Österlund ◽  
Hanna Nohynek ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Neutralizing Antibodies ◽  
Nursing Home Residents ◽  
Vaccine Dose ◽  
Spike Protein ◽  
Wild Type Virus ◽  
Elderly Subjects ◽  
Igg Antibody ◽  
Care Workers

The emergence of SARS-CoV-2 Omicron variant (B.1.1.529) with major spike protein mutations has raised concern over potential neutralization escape and breakthrough infections among vaccinated and previously SARS-CoV-2 infected subjects. We measured cross-protective antibodies against variants in health care workers (HCW, n=20) and nursing home residents (n=9) from samples collected 1-2 months following the booster (3rd) dose. We also assessed the antibody responses in prior to Omicron era infected subjects (n=38) with subsequent administration of a single mRNA vaccine dose. Following booster vaccination HCWs had high IgG antibody concentrations to the spike protein and neutralizing antibodies (NAb) were detectable against all variants. IgG concentrations among the elderly remained lower, and some lacked NAbs against the Beta and Omicron variants. NAb titers were significantly reduced against Delta, Beta and Omicron compared to wild-type virus regardless of age. Vaccination induced high IgG concentrations and variable titers of cross-reactive NAbs in previously infected subjects, whereas NAb titers against Omicron were barely detectable 1-month post-infection. High IgG concentrations with cross-protective neutralizing activity were detected after three COVID-19 vaccine doses in HCWs. However, lower NAb titers seen in the frail elderly suggest inadequate protection against Omicron breakthrough infections, yet protection against severe COVID-19 is expected.

scholarly journals Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

2020 ◽  
Author(s):  
Mina Psichogiou ◽  
Andreas Karabinis ◽  
Ioanna D. Pavlopoulou ◽  
Dimitrios Basoulis ◽  
Konstantinos Petsios ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Attack Rate ◽  
Point Of Care ◽  
Igg Antibody ◽  
Point Of Care Test ◽  
Care Workers ◽  
Potential Risk Factors ◽  
Second Wave ◽  
Weighted Prevalence

AbstractGreece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95%CI 0.06%-0.26%). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in two hospitals and assess potential risk factors. Hospital-1 was involved in the care of COVID-19 patients while hospital-2 was not. A validated, rapid, IgM/IgG antibody point-of care test was used. 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.07% (95%CI 0.37-1.78) overall and 0.44% (95%CI 0.12-1.13) and 2.4% (95%CI 0.51-8.19) in hospital-1 and hospital-2, respectively. The overall, hospital-1, and hospital-2 seroprevalence was 9, 3 and 20 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. These data have implications for the preparedness of a second wave of COVID-19 epidemic.

scholarly journals The reliability of SARS-CoV-2 IgG antibody testing – a pilot study in asymptomatic health care workers in a Croatian university hospital

2020 ◽  
Vol 61 (6) ◽  
pp. 485-490
Author(s):  
Ivana Lapić ◽  
Dunja Rogić ◽  
Dragana Šegulja ◽  
Saša Kralik Oguić ◽  
Josip Knežević
Keyword(s):  
Health Care ◽  
Pilot Study ◽  
Health Care Workers ◽  
University Hospital ◽  
Antibody Testing ◽  
Igg Antibody ◽  
Care Workers

scholarly journals Did hydroxychloroquine played crucial role as prophylactic drug against SARS-CoV-2 infection in resource-constrained and overloaded health care systems in countries like India: a prospective multicentre study in dedicated COVID hospitals

2020 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Dhaval Dalal ◽  
Ankush Govindwar ◽  
Gaurav Gangwani ◽  
Komal Dalal ◽  
Humeshwari Nipane ◽  
...  
Keyword(s):  
Health Care ◽  
Statistical Analysis ◽  
Health Care Workers ◽  
Crucial Role ◽  
Health Care Systems ◽  
Resource Constrained ◽  
Igg Antibody ◽  
Prospective Multicentre Study ◽  
Care Workers ◽  
Care Systems

Background: The Indian council medical research (ICMR) recommended to use hydroxychloroquine (HCQ) as a prophylactic agent against Severe acute respiratory syndrome coronavirus-2019 (SARS-COV-2) infection to cater need to protect high-risk individuals considering its pre-clinical data. This study explores role of HCQ in health care workers serving in coronavirus-2019 (COVID-19) pandemic.Methods: The study was planned as multi center observational study, conducted from April, 2020 to August 2020 at COVID-19 hospitals in India. HCQ 400 mg twice a day on day-1 followed by 400 mg once weekly for next 7 weeks was administered to Health care workers (HCW). RTPCR test was conducted at 3 months post last dose of prophylaxis in symptomatic health care workers. IgG test was conducted in all participants at 3 months.Results: We enrolled 1310 asymptotic frontline healthcare workers, of which 585 (45%) were male and 725 (55%) were female. Chi-Sqaure test statistical analysis in RTPCR Test showed p=0.515, p=0.634, p=0.00 in doctor and nurse, housekeeping and other staff respectively. Chi-Sqaure test statistical analysis in IgG antibody tests showed p=0.305, p=0.449 and p=o.345 in doctor and Nurse, Housekeeping and Other staff respectively.Conclusions: HCQ did not provide statistically significant pre exposure prophylaxis to doctors, nurses and housekeeping staff. However for, “other staff members category” it showed highly statistically significant prophylaxis effect with respect to RTPCR positive test results in comparison with HCW who did not consume HCQ prophylaxis. And hence HCQ could certainly play a crucial role in resource-constrained and overloaded health care systems in countries like India.

Sign in / Sign up

Export Citation Format

Share Document