scholarly journals Caveats in interpreting SARS‐CoV‐2 IgM + /IgG − antibody profile in asymptomatic health care workers

2020 ◽  
Vol 93 (2) ◽  
pp. 634-636 ◽  
Author(s):  
Arantxa Valdivia ◽  
Ignacio Torres ◽  
Dixie Huntley ◽  
María Jesús Alcaraz ◽  
Eliseo Albert ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Igg Antibody ◽  
Care Workers ◽  
Antibody Profile

scholarly journals Neutralizing antibodies to SARS-CoV-2 Omicron variant after 3rd mRNA vaccination in health care workers and elderly subjects and response to a single dose in previously infected adults

2021 ◽  
Author(s):  
Anu Haveri ◽  
Anna Solastie ◽  
Nina Ekström ◽  
Pamela Österlund ◽  
Hanna Nohynek ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Neutralizing Antibodies ◽  
Nursing Home Residents ◽  
Vaccine Dose ◽  
Spike Protein ◽  
Wild Type Virus ◽  
Elderly Subjects ◽  
Igg Antibody ◽  
Care Workers

The emergence of SARS-CoV-2 Omicron variant (B.1.1.529) with major spike protein mutations has raised concern over potential neutralization escape and breakthrough infections among vaccinated and previously SARS-CoV-2 infected subjects. We measured cross-protective antibodies against variants in health care workers (HCW, n=20) and nursing home residents (n=9) from samples collected 1-2 months following the booster (3rd) dose. We also assessed the antibody responses in prior to Omicron era infected subjects (n=38) with subsequent administration of a single mRNA vaccine dose. Following booster vaccination HCWs had high IgG antibody concentrations to the spike protein and neutralizing antibodies (NAb) were detectable against all variants. IgG concentrations among the elderly remained lower, and some lacked NAbs against the Beta and Omicron variants. NAb titers were significantly reduced against Delta, Beta and Omicron compared to wild-type virus regardless of age. Vaccination induced high IgG concentrations and variable titers of cross-reactive NAbs in previously infected subjects, whereas NAb titers against Omicron were barely detectable 1-month post-infection. High IgG concentrations with cross-protective neutralizing activity were detected after three COVID-19 vaccine doses in HCWs. However, lower NAb titers seen in the frail elderly suggest inadequate protection against Omicron breakthrough infections, yet protection against severe COVID-19 is expected.

scholarly journals Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

2020 ◽  
Author(s):  
Mina Psichogiou ◽  
Andreas Karabinis ◽  
Ioanna D. Pavlopoulou ◽  
Dimitrios Basoulis ◽  
Konstantinos Petsios ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Attack Rate ◽  
Point Of Care ◽  
Igg Antibody ◽  
Point Of Care Test ◽  
Care Workers ◽  
Potential Risk Factors ◽  
Second Wave ◽  
Weighted Prevalence

AbstractGreece is a country with limited spread of SARS-CoV-2 and cumulative infection attack rate of 0.12% (95%CI 0.06%-0.26%). Health care workers (HCWs) are a well-recognized risk group for COVID-19. The study aimed to estimate the seroprevalence of antibodies to SARS-CoV-2 in two hospitals and assess potential risk factors. Hospital-1 was involved in the care of COVID-19 patients while hospital-2 was not. A validated, rapid, IgM/IgG antibody point-of care test was used. 1,495 individuals consented to participate (response rate 77%). The anti-SARS-CoV-2 weighted prevalence was 1.07% (95%CI 0.37-1.78) overall and 0.44% (95%CI 0.12-1.13) and 2.4% (95%CI 0.51-8.19) in hospital-1 and hospital-2, respectively. The overall, hospital-1, and hospital-2 seroprevalence was 9, 3 and 20 times higher than the estimated infection attack rate in general population, respectively. Suboptimal use of personal protective equipment was noted in both hospitals. These data have implications for the preparedness of a second wave of COVID-19 epidemic.

Optimal Strategies to Screen Health Care Workers for COVID-19 in the US with SARS-CoV-2 PCR and IgG Antibody Assays

2020 ◽  
Author(s):  
Sigal Maya ◽  
Guntas Padda ◽  
Victoria Close ◽  
Trevor Wilson ◽  
Fareeda Ahmed ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Optimal Strategies ◽  
Igg Antibody ◽  
Care Workers ◽  
The Us ◽  
Antibody Assays

scholarly journals The reliability of SARS-CoV-2 IgG antibody testing – a pilot study in asymptomatic health care workers in a Croatian university hospital

2020 ◽  
Vol 61 (6) ◽  
pp. 485-490
Author(s):  
Ivana Lapić ◽  
Dunja Rogić ◽  
Dragana Šegulja ◽  
Saša Kralik Oguić ◽  
Josip Knežević
Keyword(s):  
Health Care ◽  
Pilot Study ◽  
Health Care Workers ◽  
University Hospital ◽  
Antibody Testing ◽  
Igg Antibody ◽  
Care Workers

scholarly journals Did hydroxychloroquine played crucial role as prophylactic drug against SARS-CoV-2 infection in resource-constrained and overloaded health care systems in countries like India: a prospective multicentre study in dedicated COVID hospitals

2020 ◽  
Vol 8 (1) ◽  
pp. 1
Author(s):  
Dhaval Dalal ◽  
Ankush Govindwar ◽  
Gaurav Gangwani ◽  
Komal Dalal ◽  
Humeshwari Nipane ◽  
...  
Keyword(s):  
Health Care ◽  
Statistical Analysis ◽  
Health Care Workers ◽  
Crucial Role ◽  
Health Care Systems ◽  
Resource Constrained ◽  
Igg Antibody ◽  
Prospective Multicentre Study ◽  
Care Workers ◽  
Care Systems

Background: The Indian council medical research (ICMR) recommended to use hydroxychloroquine (HCQ) as a prophylactic agent against Severe acute respiratory syndrome coronavirus-2019 (SARS-COV-2) infection to cater need to protect high-risk individuals considering its pre-clinical data. This study explores role of HCQ in health care workers serving in coronavirus-2019 (COVID-19) pandemic.Methods: The study was planned as multi center observational study, conducted from April, 2020 to August 2020 at COVID-19 hospitals in India. HCQ 400 mg twice a day on day-1 followed by 400 mg once weekly for next 7 weeks was administered to Health care workers (HCW). RTPCR test was conducted at 3 months post last dose of prophylaxis in symptomatic health care workers. IgG test was conducted in all participants at 3 months.Results: We enrolled 1310 asymptotic frontline healthcare workers, of which 585 (45%) were male and 725 (55%) were female. Chi-Sqaure test statistical analysis in RTPCR Test showed p=0.515, p=0.634, p=0.00 in doctor and nurse, housekeeping and other staff respectively. Chi-Sqaure test statistical analysis in IgG antibody tests showed p=0.305, p=0.449 and p=o.345 in doctor and Nurse, Housekeeping and Other staff respectively.Conclusions: HCQ did not provide statistically significant pre exposure prophylaxis to doctors, nurses and housekeeping staff. However for, “other staff members category” it showed highly statistically significant prophylaxis effect with respect to RTPCR positive test results in comparison with HCW who did not consume HCQ prophylaxis. And hence HCQ could certainly play a crucial role in resource-constrained and overloaded health care systems in countries like India.

scholarly journals Seroprevalence of IgG antibody against SARS-CoV-2 among health care workers of anaesthesia departments from various hospital settings in India

2021 ◽  
Author(s):  
Debaprasad Parai ◽  
Hari Ram Choudhary ◽  
Girish Chandra Dash ◽  
Annalisha Peter ◽  
Dipika Saket ◽  
...  
Keyword(s):  
Health Care ◽  
Human Resource ◽  
Health Care Workers ◽  
Rt Pcr ◽  
Igg Antibody ◽  
Routine Diagnosis ◽  
Care Workers ◽  
Anaesthesia Department ◽  
Susceptible Group ◽  
Abbott Architect

AbstractBackgroundHealth care workers (HCWs) are the most susceptible group to get COVID-19 infection and this group always need special attention as they are the key human resource to contain this pandemic.ObjectiveTo track down the seroprevalence among a particular group of HCWs working in the anaesthesia department in hospital settings.Study designTwo rounds of serosurvey were done to track the dynamicity among the 128 and 164 HCWs participants in the first round and second round, respectively. 5 mL of blood was collected and IgG SARS-CoV-2 antibody was tested in Abbott Architect i1000SR.ResultsThe seroprevalence found in the first and second round was 12.5% and 38.4%, respectively. A significant number (n=61, 77.21%) of seropositivity came from the asymptomatic HCWs group as found in both the survey. There was no significant association among different age, gender and RT-PCR tested groups.ConclusionRoutine diagnosis of COVID-19 should be referred among HCWs to identify and act upon unrecognized SARS-CoV-2 infection.

scholarly journals SARS-CoV2 IgG antibody: Seroprevalence among health care workers

2021 ◽  
pp. 100766
Author(s):  
Om Prakash ◽  
Bhavin Solanki ◽  
Jay Sheth ◽  
Govind Makwana ◽  
Mina Kadam ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Igg Antibody ◽  
Care Workers
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