Effects of Scaffold Architecture, Materials, and Loading on Cellular Micromechanical Environment in Tissue Engineering Strategies

2020 ◽  
Author(s):  
Mitchell Page ◽  
Peter Linde ◽  
Christian M. Puttlitz
Keyword(s):  
Tissue Engineering ◽  
Scaffold Architecture

Control and Monitoring of Scaffold Architecture for Tissue Engineering

2008 ◽  
pp. 69-94
Author(s):  
Ying Yang ◽  
Cassilda Cunha-Reis ◽  
Pierre Olivier Bagnaninchi ◽  
Halil Murat Aydin
Keyword(s):  
Tissue Engineering ◽  
Scaffold Architecture

Controlling the structural organization of regenerated bone by tailoring tissue engineering scaffold architecture

2012 ◽  
Vol 22 (19) ◽  
pp. 9721 ◽  
Author(s):  
Xiaohua Yu ◽  
Zengmin Xia ◽  
Liping Wang ◽  
Fei Peng ◽  
Xi Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Structural Organization ◽  
Tissue Engineering Scaffold ◽  
Scaffold Architecture

Finite element study of scaffold architecture design and culture conditions for tissue engineering

Biomaterials ◽  
2009 ◽  
Vol 30 (30) ◽  
pp. 6142-6149 ◽  
Author(s):  
Andy L. Olivares ◽  
Èlia Marsal ◽  
Josep A. Planell ◽  
Damien Lacroix
Keyword(s):  
Tissue Engineering ◽  
Finite Element ◽  
Culture Conditions ◽  
Architecture Design ◽  
Finite Element Study ◽  
Scaffold Architecture ◽  
Element Study

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

Sign in / Sign up

Export Citation Format

Share Document