In-Situ Stable Injectable Collagen-Based Hydrogels for Cell and Growth Factor Delivery

2020 ◽  
Author(s):  
Seyedsina Moeinzadeh ◽  
Youngbum Park ◽  
Sien Lin ◽  
Yunzhi Peter Yang
Keyword(s):  
Growth Factor ◽  
Growth Factor Delivery ◽  
Injectable Collagen

scholarly journals In-situ stable injectable collagen-based hydrogels for cell and growth factor delivery

Materialia ◽  
2021 ◽  
Vol 15 ◽  
pp. 100954
Author(s):  
Seyedsina Moeinzadeh ◽  
Youngbum Park ◽  
Sien Lin ◽  
Yunzhi Peter Yang
Keyword(s):  
Growth Factor ◽  
Growth Factor Delivery ◽  
Injectable Collagen

Regulated Nerve Growth Factor Delivery on Novel Polymers by hNGF-EcR-293-TK Cells

2006 ◽  
Vol 22 (06) ◽  
Author(s):  
Sanjay Dhar ◽  
Delia Radulescu ◽  
Nareg Gharibjanian ◽  
Donald Hayes ◽  
Gregory Evans
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Growth Factor Delivery ◽  
Nerve Growth

Triple Growth Factor Delivery Promotes Functional Bone Regeneration Following Composite Musculoskeletal Trauma

2021 ◽  
Author(s):  
Ramesh Subbiah ◽  
Marissa A. Ruehle ◽  
Brett S. Klosterhoff ◽  
Angela S.P. Lin ◽  
Marian H. Hettiaratchi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Growth Factor Delivery ◽  
Musculoskeletal Trauma

Apoptosis in human cultured trophoblasts is enhanced by hypoxia and diminished by epidermal growth factor

2000 ◽  
Vol 278 (5) ◽  
pp. C982-C988 ◽  
Author(s):  
Roni Levy ◽  
Steven D. Smith ◽  
Kala Chandler ◽  
Yoel Sadovsky ◽  
D. Michael Nelson
Keyword(s):  
Cell Differentiation ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Caspase Inhibitor ◽  
Trophoblast Differentiation ◽  
Epidermal Growth ◽  
Induced Apoptosis

Preeclampsia and fetal growth restriction are associated with placental hypoperfusion and villous hypoxia. The villous response to this environment includes diminished trophoblast differentiation and enhanced apoptosis. We tested the hypothesis that hypoxia induces apoptosis in cultured trophoblasts, and that epidermal growth factor (EGF), an enhancer of trophoblast differentiation, diminishes hypoxia-induced apoptosis. Trophoblasts isolated from placentas of term-uncomplicated human pregnancies were cultured up to 72 h in standard ([Formula: see text]= 120 mmHg) or hypoxic ([Formula: see text] < 15 mmHg) conditions. Exposure to hypoxia for 24 h markedly enhanced trophoblast apoptosis as determined by DNA laddering, internucleosomal in situ DNA fragmentation, and histomorphology, as well as by the reversibility of the apoptotic process with a caspase inhibitor. Apoptosis was accompanied by increased expression of p53 and Bax and decreased expression of Bcl-2. Addition of EGF to cultured trophoblasts or exposure of more differentiated trophoblasts to hypoxia significantly lowered the level of apoptosis. We conclude that hypoxia enhances apoptosis in cultured trophoblasts by a mechanism that involves an increase in p53 and Bax expression. EGF and enhancement of cell differentiation protect against hypoxic-induced apoptosis.

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