An Injectable Click-Crosslinked Hyaluronic Acid Hydrogel Modified with a BMP-2 Mimic Peptide as a Bone Tissue Engineering Scaffold

2020 ◽  
Author(s):  
Seung Hun Park ◽  
Joon Yeong Park ◽  
Yun Bae Ji ◽  
Hyun Jin Ju ◽  
Byoung Hyun Min ◽  
...  
2017 ◽  
Vol 44 (4) ◽  
pp. 428-437 ◽  
Author(s):  
Stephen M. Hamlet ◽  
Cedryck Vaquette ◽  
Amit Shah ◽  
Dietmar W. Hutmacher ◽  
Saso Ivanovski

2016 ◽  
Vol 23 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Weizhong Yang ◽  
Yong Yi ◽  
Yuan Ma ◽  
Li Zhang ◽  
Jianwen Gu ◽  
...  

AbstractNano biphasic calcium phosphate (BCP) particles were synthesized using the sol-gel method. As-prepared BCP particles were combined with poly-L-lactide (PLLA) to fabricate nano-BCP/PLLA composite scaffold through a series of processing steps containing solvent self-diffusion, hot-pressing, and particulate leaching. The composite had a suitable porous structure for bone tissue engineering scaffold. In comparison, micro-BCP/PLLA scaffold was studied as well. Nano-BCP particles were distributed homogeneously in the PLLA matrix, and much more tiny crystallites exposed on the surface of the pore wall. Due to the finer inorganic particle distribution in the PLLA phase and the larger area of the bioactive phase exposed in the pore wall surface, nano-BCP/PLLA scaffold had enhanced compressive strength, good bioactivity, and superior cell viability. A nonstoichiometric apatite layer could be rapidly formed on the surface of nano- BCP/PLLA when soaked in simulated body fluid. The MG-63 cell viability of nano-BCP/PLLA scaffold is significantly higher than that of micro-BCP/PLLA scaffold. Therefore, nano-BCP/PLLA composite may be a suitable alternative for bone tissue engineering scaffold.


2012 ◽  
Vol 7 (1) ◽  
pp. 44 ◽  
Author(s):  
M. Rubert ◽  
M. Alonso-Sande ◽  
M. Monjo ◽  
J. M. Ramis

2019 ◽  
Vol 30 (3) ◽  
pp. 777-783 ◽  
Author(s):  
Daniel Goncalves Boeckel ◽  
Patrícia Sesterheim ◽  
Thiago Rodrigues Peres ◽  
Adolpho Herbert Augustin ◽  
Krista Minéia Wartchow ◽  
...  

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