Railway Alert System | ScienceGate

In the article on set-theoretic level, developed a conceptual model of the system of special types of technical support for difficult organizational-technical system. The purpose of conceptualizing the creation of a system of interrelated and stemming from one of the other views on certain objects, phenomena, processes associated with the system of special types of technical support. In the development of applied concepts and principles of the methodology of system approach. The empirical basis for the development of the conceptual model has served many fixed factors obtained in the warning system and require formalization and theoretical explanation. The novelty of the model lies in the account of the effect of environment directly on the alert system. Therefore, in the conceptual model of the system of special types of technical support included directly in the conceptual model of the system of special types and conceptual model of the environment. Part of the conceptual model of the environment is included in the conceptual model of the enemy of nature and co-systems.

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Malignant hyperthermia susceptibility: utilization of genetic results in an electronic medical record to increase safety

Pharmacogenomics ◽

10.2217/pgs-2020-0088 ◽

2020 ◽

Vol 21 (17) ◽

pp. 1207-1215

Author(s):

Jordan F Baye ◽

Natasha J Petry ◽

Shauna L Jacobson ◽

Michelle M Moore ◽

Bethany Tucker ◽

...

Keyword(s):

Decision Support ◽

Malignant Hyperthermia ◽

Clinical Decision Support ◽

Perioperative Complications ◽

Implementation Strategies ◽

Clinical Decision ◽

Lessons Learned ◽

Malignant Hyperthermia Susceptibility ◽

Alert System ◽

Genotyping Platform

Aim: This manuscript describes implementation of clinical decision support for providers concerned with perioperative complications of malignant hyperthermia susceptibility. Materials & methods: Clinical decision support for malignant hyperthermia susceptibility was implemented in 2018 based around our pre-emptive genotyping platform. We completed a brief descriptive review of patients who underwent pre-emptive testing, focused particularly on RYR1 and CACNA1S genes. Results: To date, we have completed pre-emptive genetic testing on more than 10,000 patients; 13 patients having been identified as a carrier of a pathogenic or likely pathogenic variant of RYR1 or CACNA1S. Conclusion: An alert system for malignant hyperthermia susceptibility – as an extension of our pre-emptive genomics platform – was implemented successfully. Implementation strategies and lessons learned are discussed herein.

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