scholarly journals Computational Synthesis of Cortical Dendritic Morphologies

2020 ◽  
Author(s):  
Lida Kanari ◽  
Hugo Dictus ◽  
Athanassia Chalimourda ◽  
Werner Van Geit ◽  
Benoît Coste ◽  
...  
Keyword(s):  
Computational Synthesis

Algorithms for automated montage synthesis of images from laser-scanning confocal microscopes

1995 ◽  
Vol 53 ◽  
pp. 650-651
Author(s):  
D. E. Becker
Keyword(s):  
Image Analysis ◽  
High Resolution ◽  
Laser Scanning ◽  
Cell Counting ◽  
Wide Area ◽  
Data Set ◽  
Computational Synthesis ◽  
Automated Cell Counting ◽  
Partial View ◽  
The Individual

An efficient, robust, and widely-applicable technique is presented for computational synthesis of high-resolution, wide-area images of a specimen from a series of overlapping partial views. This technique can also be used to combine the results of various forms of image analysis, such as segmentation, automated cell counting, deblurring, and neuron tracing, to generate representations that are equivalent to processing the large wide-area image, rather than the individual partial views. This can be a first step towards quantitation of the higher-level tissue architecture. The computational approach overcomes mechanical limitations, such as hysterisis and backlash, of microscope stages. It also automates a procedure that is currently done manually. One application is the high-resolution visualization and/or quantitation of large batches of specimens that are much wider than the field of view of the microscope.The automated montage synthesis begins by computing a concise set of landmark points for each partial view. The type of landmarks used can vary greatly depending on the images of interest. In many cases, image analysis performed on each data set can provide useful landmarks. Even when no such “natural” landmarks are available, image processing can often provide useful landmarks.

The Intelligence of Computational Design

2018 ◽  
pp. 228-250
Author(s):  
Luciana Parisi
Keyword(s):  
Cognitive Activity ◽  
Computational Design ◽  
Human Cognition ◽  
Artificial System ◽  
Instrumental Approach ◽  
Computational Synthesis ◽  
Data Flows

Luciana Parisi in her chapter goes on to discuss the creative act towards novelty that comes from the nonhuman computational synthesis of logics and granular calculation of variations away from human cognition and perception based on given premises. The essay proposes an instrumental approach to design as a technology or a cognitive activity able to transform the environment by inducing new correlations of vast amounts of varied data flows. This chapter addresses the emergence of this neo-materialist approach as a symptom of a new conceptualisation of nature that no longer corresponds to the cybernetic view of an artificial system of feedback relations. It further suggests that there are some important inconsistencies between the computational conception of nature and the new rationality of the natural. Computational materiality implies a naturalisation of design intended as techne, or instrumentality, and defined not by logical aims, but operations, procedures and means that cut across strata, rules, forms and go beyond the specific constraints of each and any form.

scholarly journals Integrating functional synthesis

2005 ◽  
Vol 19 (3) ◽  
pp. 183-200
Author(s):  
WILLIAM H. WOOD ◽  
HUI DONG ◽  
CLIVE L. DYM
Keyword(s):  
Integrated Design ◽  
Knowledge Bases ◽  
Design Environment ◽  
Simulation Tools ◽  
Domain Specific ◽  
Computational Synthesis ◽  
Domain Specific Knowledge ◽  
Design Function ◽  
Comprehensive Search ◽  
Abstraction Levels

Design couples synthesis and analysis in iterative cycles, alternatively generating solutions, and evaluating their validity. The accuracy and depth of evaluation has increased markedly because of the availability of powerful simulation tools and the development of domain-specific knowledge bases. Efforts to extend the state of the art in evaluation have unfortunately been carried out in stovepipe fashion, depending on domain-specific views both of function and of what constitutes “good” design. Although synthesis as practiced by humans is an intentional process that centers on the notion of function, computational synthesis often eschews such intention for sheer permutation. Rather than combining synthesis and analysis to form an integrated design environment, current methods focus on comprehensive search for solutions within highly circumscribed subdomains of design. This paper presents an overview of the progress made in representing design function across abstraction levels proven useful to human designers. Through an example application in the domain of mechatronics, these representations are integrated across domains and throughout the design process.

Kinematic Design and Evaluation of a Six-Bar Knee-Ankle-Foot Orthosis

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Shramana Ghosh ◽  
Nina P. Robson ◽  
J. Michael McCarthy
Keyword(s):  
Knee Joint ◽  
Motion Capture ◽  
Performance Optimization ◽  
Design Procedure ◽  
Motion Capture Data ◽  
Ankle Foot Orthosis ◽  
Kinematic Design ◽  
Computational Synthesis ◽  
Kinematic Evaluation ◽  
Foot Orthosis

Abstract This paper presents a new two-step design procedure and preliminary kinematic evaluation of a novel, passive, six-bar knee-ankle-foot orthosis (KAFO). The kinematic design and preliminary kinematic gait analysis of the KAFO are based on motion capture data from a single healthy male subject. Preliminary kinematic evaluation shows that the designed passive KAFO is capable of supporting flexion and extension of the knee joint during stance and swing phases of walking. The two-step design procedure for the KAFO consists of (1) computational synthesis based on user's motion data and (2) performance optimization. In the computational synthesis step, first the lower leg (knee-ankle-foot) of the subject is approximated as a 2R kinematic chain and its target trajectories are specified from motion capture data. Six-bar linkages are synthesized to coordinate the angular movements of knee and ankle joints of the 2R chain at 11 accuracy points. The first step of the design procedure yields 332 six-bar KAFO design candidates. This is followed by a performance optimization step in which the KAFO design candidates are optimally modified to satisfy specified constraints on end-effector trajectory and shape. This two-step process yields an optimally designed passive six-bar KAFO that shows promising kinematic results at the knee joint of the user during walking. The preliminary prototype manufactured is cost effective, easy to operate, and suitably demonstrates the feasibility of the proposed concept.

A Clock Grammar: The Use of a Parallel Grammar in Performance-Based Mechanical Synthesis

2002 ◽  
Author(s):  
Alex C. Starling ◽  
Kristina Shea
Keyword(s):  
Mechanical Systems ◽  
Test Methods ◽  
Structure Design ◽  
Design Model ◽  
Spatial Constraints ◽  
Mechanical Synthesis ◽  
Computational Synthesis ◽  
Parts Library ◽  
Performance Considerations

Effective methods of computational synthesis for mechanical systems must represent both function and structure in order to generate physical designs with desired behaviors. To this aim, a parallel grammar for mechanical synthesis was developed based on a Function-Behavior-Structure design model. This parallel grammar was implemented for the domain of mechanical clocks and watches in order to demonstrate the flexibility and strengths of the approach. Designs were produced using a fully parametric parts library. Incorporating performance considerations, generate-and-test methods were then used to produce clock designs that satisfy different sets of spatial constraints to demonstrate the potential of the method for general mechanical synthesis problems.

Computational Synthesis of MoS2 Layers by Reactive Molecular Dynamics Simulations: Initial Sulfidation of MoO3 Surfaces

Nano Letters ◽  
2017 ◽  
Vol 17 (8) ◽  
pp. 4866-4872 ◽  
Author(s):  
Sungwook Hong ◽  
Aravind Krishnamoorthy ◽  
Pankaj Rajak ◽  
Subodh Tiwari ◽  
Masaaki Misawa ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Reactive Molecular Dynamics ◽  
Computational Synthesis ◽  
Dynamics Simulations
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