Metabolic Targeting of Intestinal Microbiome and Bile Acid Metabolism by Mangxiao as Potential Therapies of Colorectal Cancer

2020 ◽  
Author(s):  
Xi-Jun Wang ◽  
Xiao-Hang Zhou ◽  
Ai-Hua Zhang ◽  
Hui Sun ◽  
Hong-Lian Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Acid Metabolism ◽  
Intestinal Microbiome ◽  
Bile Acid Metabolism ◽  
Metabolic Targeting

scholarly journals Network pharmacology combined with functional metabolomics discover bile acid metabolism as a promising target for mirabilite against colorectal cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (53) ◽  
pp. 30061-30070 ◽  
Author(s):  
Hui Sun ◽  
Hong-lian Zhang ◽  
Ai-hua Zhang ◽  
Xiao-hang Zhou ◽  
Xiang-qian Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Acid Metabolism ◽  
Network Pharmacology ◽  
Bile Acid Metabolism ◽  
Promising Target ◽  
Functional Metabolomics

In this study, a combination of network pharmacology and metabolomics was used to explore the mechanism by which mirabilite regulates bile acid metabolism in the treatment of colorectal cancer.

scholarly journals Abstract LB-213: Thrombospondin-1 regulates intestinal microbiota and bile acid metabolism in a murine model of colorectal cancer

2017 ◽  
Author(s):  
David R. Soto-Pantoja ◽  
John M. Sipes ◽  
Brian Westwood ◽  
Nicole Morris ◽  
Nancy J. Emenaker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Intestinal Microbiota ◽  
Murine Model ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Thrombospondin 1

scholarly journals Anomalies in Network Bridges Involved in Bile Acid Metabolism Predict Outcomes of Colorectal Cancer Patients

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107925 ◽  
Author(s):  
Sunjae Lee ◽  
KiYoung Lee ◽  
Seyeol Yoon ◽  
Jae W. Lee ◽  
Doheon Lee
Keyword(s):  
Colorectal Cancer ◽  
Bile Acid ◽  
Cancer Patients ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Colorectal Cancer Patients

T cell mediated cholangitis alters bile acid metabolism

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
F Glaser ◽  
C John ◽  
B Engel ◽  
B Höh ◽  
S Weidemann ◽  
...  
Keyword(s):  
Bile Acid ◽  
T Cell ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

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